A5044869736- Cancer, Hypoxia, and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer and Skin Lesions
- Multiple and Secondary Primary Cancers
- Immune cells in cancer
- Nonmelanoma Skin Cancer Studies
- Phagocytosis and Immune Regulation
- Hematological disorders and diagnostics
- Genomic variations and chromosomal abnormalities
- HER2/EGFR in Cancer Research
- Male Breast Health Studies
- Acute Myocardial Infarction Research
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- BRCA gene mutations in cancer
- Genetic and rare skin diseases.
- Chemotherapy-related skin toxicity
- Congenital limb and hand anomalies
- Chemotherapy-induced organ toxicity mitigation
- PI3K/AKT/mTOR signaling in cancer
- Erythropoietin and Anemia Treatment
- Kruppel-like factors research
The University of Tokyo
2001-2023
National Cancer Centre Japan
2020-2022
RELX Group (United States)
2020-2022
St. Luke's International Hospital
2017-2020
St. Luke's International University
2019
Cancer Services
2019
Tisch Hospital
2009
Cancer Institute (WIA)
2009
University of Tsukuba
2008
Kyoto University
1986-2008
The incidence and mortality rates of endometrial cancer are increasing globally, including in Japan. Quality care is promoted through guideline adherence. This study aimed to establish quality indicators (QIs) for explore the factors contributing treatment nonadherence. QIs pattern-of-care (PCIs) were developed using Research Development/University California Los Angeles modified Delphi method. reflect desirable healthcare patterns, whereas PCIs address areas with lacking evidence. Data from...
The incidence of male breast cancer (MBC), although rare, has shown an increase. However, the current epidemiology and practice patterns for MBC remain unclear. This study evaluated characteristics care compared with female (FBC) in Japan.Using National Database Hospital-Based Cancer Registries (HBCR) linked to Diagnosis Procedure Combination data, we analyzed newly diagnosed cases between January 2012 December 2015 at participating hospitals a large quality-of-care monitoring project. We...
We describe a de novo apparently balanced reciprocal translocation, 46,X,t(X;16)(q28;q11.2), in 13 year old girl with median cleft of the upper lip, pedunculated skin masses on nasal septum, short stature, and mental retardation. Pai syndrome is characterised by mass(es) face, midline lipoma(s) central nervous system. The cause this unknown, although autosomal dominant inheritance has been proposed. translocation breakpoints present patient may be candidate regions for gene responsible lip...
Agents that block vascular endothelial growth factor (VEGF) and its downstream pathway have been reported to be associated with nephrotoxicity including hypertension, proteinuria, renal dysfunction. Bevacizumab, a monoclonal antibody against VEGF, is known cause thrombotic microangiopathy (TMA), while tyrosine kinase inhibitors (TKIs) VEGF are mainly minimal change disease or focal segmental glomerulosclerosis. The question regarding the source of diverse phenotypes these agents remains...
Chronic kidney disease (CKD) affects cancer patients' mortality. However, the underlying mechanism remains unknown. M2-like macrophages have pro-tumor functions, also exist in injured kidney, and promote fibrosis. Thus, it is suspected that induce microenvironment leading to progression. We found present promoted progression induced resistance anti-PD1 antibody through its function inhibition of CD8+ T cell infiltration. RNA-seq revealed Slc7a11 was upregulated macrophages. Inhibition with...
ABSTRACT Malignant cutaneous adnexal tumors (MCATs) are rare. Previous population‐based studies to determine the clinical features and prognosis of MCATs mainly included Caucasian patients, characteristics Asian patients with have not yet been investigated. We aimed investigate MCAT using a Japanese database. This retrospective study from 2012 2015 was conducted database linked Hospital‐Based Cancer Registry Diagnosis Procedure Combination data. Patient survival data were analyzed...
Abstract Background Sentinel lymph node biopsy (SLNB) underuse has been reported for skin cancers; however, actual performance rates have not compared. The objective of this study was to investigate the SLNB rate in cancers covered by health insurance Japan and compare it with that breast cancer. Methods This a retrospective SLNB‐eligible patients or cancer from 2018 2019, utilizing database linked Hospital‐Based Cancer Registry Diagnosis Procedure Combination survey. Demographic tumor...
The optimum condition for gastric carcinomas to be induced by N-methyl-N-nitrosourea (MNU) selectively in the glandular portions of rat stomach was investigated. MNU drinking water at various dose levels with shielding from light administered ad libitum a group inbred male F344 rats 15 weeks and thereafter switched tap maintain them further 25 weeks. received concentration more than 200 ppm resulted high mortality because chronic toxicity after withdrawal MNU. Administration 100 followed...
Although trastuzumab and anthracyclines are frequently used to treat breast cancer (BC) gastric (GC), cardiotoxicity is a serious concern. The cardiac function assessment recommended at baseline before initiating treatment. However, the prevalence rates of checkups unknown.The national database hospital-based registries linked health services-utilization data was study patients with newly diagnosed stage IV BC GC (n = 6271) who received 4324, 69.0%) or between January 2012 December 2015....
Abstract Background The survival of hemodialysis (HD) patients with cancer is poor, which may be caused by undertreatment due to renal dysfunction. Particularly, adjuvant chemotherapy after surgery considered optional because its preventive nature. This study investigated the current frequency administration HD compared non‐HD in Japan. Methods We used data from Hospital‐Based Cancer Registries national database linked health services utilization analyze cases newly diagnosed colon cancer,...