A5054681594- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Obsessive-Compulsive Spectrum Disorders
- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Diabetes and associated disorders
- Eating Disorders and Behaviors
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Diabetes Management and Research
- Receptor Mechanisms and Signaling
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Diabetes Treatment and Management
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Metabolism and Genetic Disorders
- Growth Hormone and Insulin-like Growth Factors
- Alcoholism and Thiamine Deficiency
- Palliative Care and End-of-Life Issues
- Attention Deficit Hyperactivity Disorder
Osaka University
2009-2023
Japan Tobacco (Japan)
2009-2023
The University of Tokyo
1990-2020
University of Tokyo Hospital
2019
Kyoto Prefectural University of Medicine
2009-2018
Kyoto first Red Cross hospital
2011-2016
Harvard University
2015
Hanazono University
2015
Joslin Diabetes Center
2015
Megmilk Snow Brand (Japan)
2001-2011
The effect of persistent symptoms or compensatory processes related to cognitive dysfunction in obsessive-compulsive disorder may contribute brain structure alterations OCD, indicating that age is an important factor evaluating changes gray and white matter volumes.
The basal ganglia represents a key component of the pathophysiological model for obsessive-compulsive disorder (OCD). This brain region is part several neural circuits, including orbitofronto-striatal circuit and dorsolateral prefronto-striatal circuit. There are, however, no published studies investigating those circuits at network level in non-medicated patients with OCD. Resting state functional magnetic resonance imaging scans were obtained from 20 OCD 23 matched healthy volunteers....
Prolyl hydroxylase domain (PHD) inhibitors, which stimulate erythropoietin production through the activation of hypoxia-inducible factor (HIF), are novel therapeutic agents used for treating renal anemia. Several PHD including enarodustat, currently undergoing phase 2 or 3 clinical trials. Because HIF regulates a broad spectrum genes, inhibitors expected to have other effects in addition erythropoiesis, such as protection against metabolic disorders. However, whether beneficial would extend...
Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, also known as HIF stabilizers, increase endogenous erythropoietin production and serve novel therapeutic agents against anemia in chronic kidney disease. induces the expression of various genes related to energy metabolism an adaptive response hypoxia. However, it remains obscure how metabolic reprogramming renal tissue by stabilization affects pathophysiology diseases. Previous studies suggest that systemic disorders such...
Mitochondrial protein traffic requires precise recognition of the mitochondrial targeting signals by import receptors on surface including a general receptor Tom20 and for presequence-less proteins, Tom70. Here we took proteome-wide approach in vitro to find set presequence-containing precursor proteins The presequences Tom70-dependent were recognized Tom20, whereas their mature parts exhibited when attached presequence Tom70-independent proteins. have propensity aggregate, presence domain...
Many studies reported the high prevalence of problematic internet use (PIU) among adolescents (13–50%), and PIU was associated with various psychiatric symptoms. In contrast, only a few investigated adult population (6%). This study aimed to investigate co-morbidity patients. Three hundred thirty-three patients were recruited over 3-month period. Two thirty-one them completed survey (response rate: 69.4%, 231/333; Male/Female/Transgender: 90/139/2; mean age = 42.2). We divided participants...
We examined how aromatherapy massage influenced psychologic and immunologic parameters in 12 breast cancer patients an open semi-comparative trial. compared the results 1 month before as a waiting control period with those during treatment after completion of sessions. The received 30 min twice week for 4 weeks (eight times total). showed that anxiety was reduced one State-Trait Anxiety Inventory (STAI) test also eight sequential sessions Hospital Depression Scale (HADS) test. Our further...
This preliminary investigation compares peripheral blood cell counts including red cells (RBCs), white (WBCs), neutrophils, lymphocytes (PBLs), CD4(+), CD8(+) and CD16(+) lymphocytes, CD4(+)/CD8(+) ratio, hematocrit, humoral parameters serum interferon-gamma interleukin-6, salivary secretory immunoglobulin A (IgA). Psychological measures the State-Trait Anxiety Inventory (STAI) questionnaire Self-rating Depression Scale (SDS) between recipients (n = 11) of carrier oil massage aromatherapy...
Dysfunction of the fronto-striato-thalamic circuit routing through orbitofrontal cortex (OFC) is thought to play main role in pathophysiology obsessive-compulsive disorder (OCD). Repetitious stimulation OFC-ventral striatum (VS) projections mice has been shown increase firing postsynaptic VS cells and frequency OCD-like symptoms. Moreover, increased functional connectivity (FC) between OFC reported patients with OCD. While FC a synchronous, non-directed correlation, directed influence these...
To investigate relationships among burnout, coping style and personality.Seventy-two professional caregivers working at nursing homes in Japan were assessed using the Maslach Burnout Inventory (MBI), NEO Five-Factor (NEO-FFI), 30-item General Health Questionnaire (GHQ) Coping for Stressful Situation (CISS).GHQ (beta = 0.34, P < 0.01) emotion-oriented (CISS-E; beta 0.31, 0.05) predictors of emotional exhaustion (MBI-EE), neuroticism (NEO-N; 0.45, 0.001) age -0.23, depersonalization (MBI-DP)....