Takashi Nakamae
A5043802283- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Eating Disorders and Behaviors
- Advanced Neuroimaging Techniques and Applications
- Body Image and Dysmorphia Studies
- Neural and Behavioral Psychology Studies
- Botulinum Toxin and Related Neurological Disorders
- Digital Mental Health Interventions
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Dementia and Cognitive Impairment Research
- Telemedicine and Telehealth Implementation
- Mental Health and Psychiatry
- Healthcare professionals’ stress and burnout
- Psychosomatic Disorders and Their Treatments
- Impact of Technology on Adolescents
- Quantum Mechanics and Non-Hermitian Physics
- Transcranial Magnetic Stimulation Studies
- Hemispheric Asymmetry in Neuroscience
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
Kyoto Prefectural University of Medicine
2015-2025
Hiroshima University
2023
Sunovion (United States)
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
World Federation of Public Health Associations
2018
University of Amsterdam
2016
Advanced Telecommunications Research Institute International
2014-2015
Kyoto Prefectural University
2012
Saiseikai Suita Hospital
2011
Shimane University
1990
The effect of persistent symptoms or compensatory processes related to cognitive dysfunction in obsessive-compulsive disorder may contribute brain structure alterations OCD, indicating that age is an important factor evaluating changes gray and white matter volumes.
The basal ganglia represents a key component of the pathophysiological model for obsessive-compulsive disorder (OCD). This brain region is part several neural circuits, including orbitofronto-striatal circuit and dorsolateral prefronto-striatal circuit. There are, however, no published studies investigating those circuits at network level in non-medicated patients with OCD. Resting state functional magnetic resonance imaging scans were obtained from 20 OCD 23 matched healthy volunteers....
Objective: Brain imaging communities focusing on different diseases increasingly start collaborating and pooling data to perform well-powered meta- mega-analyses. Some methodologists claim that a one-stage individual-participant mega-analysis can be superior two-stage aggregated meta-analysis, since more detailed computations performed in mega-analysis. Before definitive conclusions regarding the performance of either method drawn, it is necessary critically evaluate methodology of, results...
Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to common trajectories development maturation.Large-scale investigation obsessive-compulsive disorder (OCD) may provide clues the pathophysiology this neurodevelopmental disorder.Using T 1 -weighted MRI scans acquired from 1616 individuals with OCD 1463 healthy controls across 37 datasets participating ENIGMA-OCD Working Group, we calculated intra-individual (using...
Abstract Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, majority studies have focused only predefined regions or networks rather than throughout entire brain. Here, we investigated differences resting-state between OCD patients and healthy controls (HC) using mega-analysis data from 1024 1028 HC 28 independent samples ENIGMA-OCD consortium. We assessed group...
Abstract Obsessive-compulsive disorder (OCD) is a common psychiatric with lifetime prevalence of 2–3%. Recently, brain activity in the resting state gathering attention for exploring altered functional connectivity disorders. Although previous resting-state magnetic resonance imaging studies investigated neurobiological abnormalities patients OCD, there are concerns that should be addressed. One concern validity hypothesis employed. Most used seed-based analysis fronto-striatal circuit,...
Many studies reported the high prevalence of problematic internet use (PIU) among adolescents (13–50%), and PIU was associated with various psychiatric symptoms. In contrast, only a few investigated adult population (6%). This study aimed to investigate co-morbidity patients. Three hundred thirty-three patients were recruited over 3-month period. Two thirty-one them completed survey (response rate: 69.4%, 231/333; Male/Female/Transgender: 90/139/2; mean age = 42.2). We divided participants...
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures cortical thickness, surface area subcortical volume tested classification performance cross-validation. Classification vs. complete sample different classifiers cross-validation strategies was...
Microstructural alterations in cortico-subcortical connections are thought to be present obsessive-compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power detect subtle abnormalities. Here we investigated microstructural white matter and their relation clinical features the largest dataset of adult pediatric OCD date. We analyzed diffusion tensor imaging metrics from 700 patients 645 controls, as...
Dysfunction of the fronto-striato-thalamic circuit routing through orbitofrontal cortex (OFC) is thought to play main role in pathophysiology obsessive-compulsive disorder (OCD). Repetitious stimulation OFC-ventral striatum (VS) projections mice has been shown increase firing postsynaptic VS cells and frequency OCD-like symptoms. Moreover, increased functional connectivity (FC) between OFC reported patients with OCD. While FC a synchronous, non-directed correlation, directed influence these...
Abstract Background Electroconvulsive therapy (ECT) is indicated in major depression, mania, and schizophrenia a Task Force Report of the American Psychiatric Association, Royal Australian New Zealand College Psychiatrists professional practice guidelines, revised recommendations for ECT compiled by Japanese Neuropsychiatric Society General Hospital Psychiatry. Even though each organization provides similar it has been reported that there large global variation utilization. Although are some...
To investigate relationships among burnout, coping style and personality.Seventy-two professional caregivers working at nursing homes in Japan were assessed using the Maslach Burnout Inventory (MBI), NEO Five-Factor (NEO-FFI), 30-item General Health Questionnaire (GHQ) Coping for Stressful Situation (CISS).GHQ (beta = 0.34, P < 0.01) emotion-oriented (CISS-E; beta 0.31, 0.05) predictors of emotional exhaustion (MBI-EE), neuroticism (NEO-N; 0.45, 0.001) age -0.23, depersonalization (MBI-DP)....
Live two-way video, easily accessible from home via smartphones and other devices, is becoming a new way of providing psychiatric treatment. However, lack evidence for real-world clinical setting effectiveness hampers its approval by medical insurance in some countries. Here, we conducted the first large-scale pragmatic, randomized controlled trial to determine long-term treatment multiple disorders video using which are currently primary means telecommunication.