A5001108821- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Early Childhood Education and Development
- Memory and Neural Mechanisms
- Eating Disorders and Behaviors
- Behavioral and Psychological Studies
- Mental Health Research Topics
- Health Policy Implementation Science
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Infant Development and Preterm Care
- Neuroendocrine regulation and behavior
- Resilience and Mental Health
- Sexual function and dysfunction studies
- Body Image and Dysmorphia Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Digital Mental Health Interventions
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
Columbia University
2021-2025
University of Michigan
2014-2024
New York Psychoanalytic Society and Institute
2022-2024
New York State Psychiatric Institute
2021-2024
Columbia University Irving Medical Center
2023-2024
University of Wisconsin–Madison
2023
New York State Office of Mental Health
2022
Changzhi Medical College
2022
Central South University
2020-2022
Second Xiangya Hospital of Central South University
2020-2022
Background Obsessive-compulsive disorder (OCD) is characterized by an excessive focus on upsetting or disturbing thoughts, feelings, and images that are internally-generated. Internally-focused thought processes subserved the “default mode network" (DMN), which has been found to be hyperactive in OCD during cognitive tasks. In healthy individuals, disengagement from internally-focused may rely interactions between DMN a fronto-parietal network (FPN) associated with external attention task...
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
Attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), and obsessive-compulsive (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these using structural brain imaging data from ENIGMA consortium data.
Making an error elicits activity from brain regions that monitor performance, especially the medial frontal cortex (MFC). However, uncertainty exists about whether posterior or anterior/rostral MFC processes errors and to what degree affective responses are mediated in MFC, specifically rostral anterior cingulate (rACC). To test hypothesis rACC mediates a type of response, we conceptualized affect response as reaction loss amplified this with monetary penalty. While subjects performed...
Background The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. error-related negativity (ERN) is a negative deflection event-related potential following an erroneous response and thought to reflect ACC activity. This study was done assess ERN as biomarker for OCD by comparing amplitudes pediatric patients, unaffected siblings healthy controls. Methods...
Abstract The ability to process and respond emotional facial expressions is a critical skill for healthy social development. There has been growing interest in understanding the neural circuitry underlying development of processing, with previous research implicating functional connectivity between amygdala frontal regions. However, existing work focused on threatening faces, raising questions regarding extent which these developmental patterns are specific threat or face processing more...
Childhood anxiety and depression often go undiagnosed. If left untreated these conditions, collectively known as internalizing disorders, are associated with long-term negative outcomes including substance abuse increased risk for suicide. This paper presents a new approach identifying young children disorders using 3-min speech task. We show that machine learning analysis of audio data from the task can be used to identify an disorder 80% accuracy (54% sensitivity, 93% specificity). The...
Objective: Brain imaging communities focusing on different diseases increasingly start collaborating and pooling data to perform well-powered meta- mega-analyses. Some methodologists claim that a one-stage individual-participant mega-analysis can be superior two-stage aggregated meta-analysis, since more detailed computations performed in mega-analysis. Before definitive conclusions regarding the performance of either method drawn, it is necessary critically evaluate methodology of, results...
Obsessive-compulsive disorder (OCD) is often associated with pathological uncertainty regarding whether an action has been performed correctly or a bad outcome will occur, leading to compulsive "evidence gathering" behaviors aimed at reducing uncertainty. The current study used event-related functional magnetic resonance imaging investigate neural functioning in OCD patients and controls as subjective certainty was rated response sequential pieces of evidence for decision. Uncertainty...