Danai Dima
A5006464992- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Neural and Behavioral Psychology Studies
- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- Face Recognition and Perception
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Electroconvulsive Therapy Studies
- Advanced MRI Techniques and Applications
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Multisensory perception and integration
- Maternal Mental Health During Pregnancy and Postpartum
City, University of London
2016-2025
King's College London
2015-2024
University of London
2023
Radboud University Medical Center
2019
Universidad de Londres
2017-2019
University of Southern California
2019
Radboud University Nijmegen
2019
Max Planck Institute for Psycholinguistics
2019
Amsterdam Neuroscience
2019
The Ohio State University
2019
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying sources of can help generate novel clinical hypotheses etiology assist in development biomarkers for indexing disease progression prognosis. Here we were interested case-control differences intracranial volume (ICV) each eight subcortical measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies may obscure or distort lifespan trajectories of morphometry. In response, we capitalized resources Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related inferred from cross-sectional measures ventricles, basal ganglia...
Background The neurobiological underpinnings of avolition in schizophrenia remain unclear. Most brain imaging research has focused on reward prediction deficit and ventral striatum dysfunction, but findings are not consistent. In the light accumulating evidence that both dorsal caudate play a key role motivation, we investigated activation during processing or loss patients with schizophrenia. Method We used functional magnetic resonance to study Monetary Incentive Delay task schizophrenia,...
Abstract Background Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim this study was to examine whether CM severity and type are associated with MDD-related brain alterations, how they interact sex age. Methods Within ENIGMA-MDD network, subtypes using Trauma Questionnaire were assessed structural magnetic resonance imaging data from patients MDD healthy controls analyzed a mega-analysis comprising total 3872 participants aged...
Recent studies have shown that choroid plexuses (CP) may be involved in the neuro-immune axes, playing a role interaction between central and peripheral inflammation. Here we aimed to investigate CP volume alterations depression their associations with inflammation.51 depressed participants (HDRS score > 13) 25 age- sex-matched healthy controls (HCs) from Wellcome Trust NIMA consortium were re-analysed for study. All underwent full cytokine profiling simultaneous [11C]PK11195 PET/structural...
Abstract Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, diagnostic predictive power of existing algorithms has been limited by small sample sizes, lack representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with largest multi-site size date (N = 5365) provide a generalizable ML classification benchmark major depressive disorder (MDD) using shallow...
The perception of facial affect engages a distributed cortical network. We used functional magnetic resonance imaging and dynamic causal modeling to characterize effective connectivity during explicit (conscious) categorization affective stimuli in the human brain. Specifically, we examined modulation from posterior regions face-processing network lateral ventral prefrontal cortex (VPFC) tested for potential role amygdala (AMG) mediating this modulation. found that processing led prominent...
Genome-wide association studies (GWASs) indicate that single-nucleotide polymorphisms in the CACNA1C and ANK3 genes increase risk for bipolar disorder (BD). The influence neuronal firing by modulating calcium sodium channel functions, respectively. Both modulate γ-aminobutyric acid-transmitting interneuron function can thus affect brain regional activation interregional connectivity.To determine whether genetic BD associated with 2 GWAS-supported at rs1006737 rs10994336 is mediated through...
Abstract Variation in telomere length is heritable and currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because its association with memory function hippocampal morphology. Here, we investigate connection to familial risk disease expression bipolar disorder (BD). We used quantitative PCRs telomere-sequence single-copy-gene-sequence ratio method determine genomic DNA extracted from buccal smears 63 patients BD, 74 first-degree relatives...
Bipolar disorder (BD) is characterized by emotional dysregulation and cognitive deficits associated with abnormal connectivity between subcortical-primarily processing regions-and prefrontal regulatory areas. Given the significant contribution of genetic factors to BD, studies in unaffected first-degree relatives can identify neural mechanisms risk but also resilience, thus paving way for preventive interventions. Dynamic causal modeling (DCM) random-effects Bayesian model selection were...