Yash Patel
A5101503348- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Single-cell and spatial transcriptomics
- Diet and metabolism studies
- Attention Deficit Hyperactivity Disorder
- Neuroinflammation and Neurodegeneration Mechanisms
- Economic Growth and Productivity
- Neurological Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- Autism Spectrum Disorder Research
- Neurological and metabolic disorders
- Acute Ischemic Stroke Management
- Cancer-related Molecular Pathways
- Health Systems, Economic Evaluations, Quality of Life
- Neurogenesis and neuroplasticity mechanisms
- Medication Adherence and Compliance
- Tryptophan and brain disorders
- MRI in cancer diagnosis
- Visual perception and processing mechanisms
- Fetal and Pediatric Neurological Disorders
- Neural dynamics and brain function
- Chemotherapy-induced cardiotoxicity and mitigation
- Wireless Sensor Networks and IoT
- Racial and Ethnic Identity Research
Directorate of Medicinal and Aromatic Plants Research
2025
University of Houston
2025
University of Toronto
2018-2024
Hospital for Sick Children
2020-2024
Charotar University of Science and Technology
2024
3M (United States)
2024
National Institute of Mental Health
2023
Drexel University
2023
B.J. Medical College
2022
Indus University
2022
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet neurobiological substrates are poorly understood. Here, we used a virtual-histology technique gene expression data from Allen Human Brain Atlas compare regional profiles of longitudinal cortical through (4004 magnetic resonance images [MRIs]) with those for several neuronal non-neuronal cell types. The results were replicated in three independent datasets. We found that inter-regional related...
<h3>Importance</h3> Many psychiatric disorders can be conceptualized as of brain maturation during childhood and adolescence. Discovering the neurobiological underpinnings may elucidate molecular pathways vulnerability resilience to such disorders. <h3>Objective</h3> To investigate underlying mechanisms age-associated cortical thinning their implications for <h3>Design, Setting, Participants</h3> This multicohort analysis used data from 3 community-based studies. The Saguenay Youth Study...
Neurobiology underlying inter-regional variations - across the human cerebral cortex in measures derived with multi-modal magnetic resonance imaging (MRI) is poorly understood. Here, we characterize a large number of such measures, including T1 and T2 relaxation times, myelin water fraction (MWF), T1w/T2w ratio, mean diffusivity (MD), fractional anisotropy (FA), magnetization transfer ratio (MTR) cortical thickness. We then employ virtual-histology approach relate these profiles to those...
The size of the human head is highly heritable, but genetic drivers its variation within general population remain unmapped. We perform a genome-wide association study on (N = 80,890) and identify 67 loci, which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, most have widespread effects. Gene set enrichment observed for various cancers p53, Wnt, ErbB signaling pathways. Genes harboring lead enriched macrocephaly syndrome genes (37-fold) high-fidelity...
Previous in vivo studies revealed robust age-related variations structural properties of the human cerebral cortex during adolescence. Neurobiology underlying these maturational phenomena is largely unknown. Here we employ a virtual-histology approach to gain insights into processes associated with inter-regional cortical microstructure and its maturation, as indexed by magnetization transfer ratio (MTR). Inter-regional MTR correlate expression genes specific pyramidal cells (CA1) ependymal...
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD RD), more recently, peak width skeletonized mean (PSMD), have been proposed potential markers normal pathological brain ageing. However, their relative evolution over the entire adult lifespan healthy individuals remains partly unknown during early late adulthood, particularly for PSMD index. Here, we gathered analyzed...
Poor adherence to oral endocrine therapy (OET) is a significant problem among patients with hormone receptor-positive breast cancer as it results in higher risk of recurrence and mortality. Non-adherence OET prevalent underserved patients, often attributable socioeconomic factors limited healthcare access. We evaluated patterns over time using group-based trajectory modeling (GBTM) identified predictors suboptimal seen at Harris Health System, serving Houston, Texas. A single-center,...
Importance: In prior work, a transgenic mouse model of the striatal dopamine dysfunction observed in persons with schizophrenia (PSZ) exhibited dopamine-related neuroplasticity basal ganglia. This phenotype has never been demonstrated human PSZ. Objective: To identify specific alteration ganglia connectivity via task-based and resting-state functional magnetic resonance imaging (fMRI), neuromelanin-sensitive MRI (NM-MRI), positron emission tomography (PET), unmedicated Design: case-control...
General psychopathology and cognition are likely to have a bidirectional influence on each other. Yet, the relationship between brain structure, psychopathology, remains unclear. This brief report investigates association structural properties of cerebral cortex [surface area, cortical thickness, intracortical myelination indexed by T1w/T2w ratio, neurite density assessed restriction spectrum imaging (RSI)] with general in sample children from Adolescent Brain Cognitive Development (ABCD)...
Abstract Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD) exposure remains uncertain. We compared differential in prefrontal cortex SCZ patients who tested positive for APDs at time death with did not. APD was associated numerous brain transcriptome, especially among on atypical APDs. Brain transcriptome data from macaques chronically...
OBJECTIVE To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) identify potential cellular mechanisms involved. RESEARCH DESIGN AND METHODS A cohort of 30,579 adults age 45 to 81 (mean ± SD: 64 7.5) years with available data on brain MRI HbA1c levels was analyzed. The CT probed using independent spatial profiles cell-specific gene expression. Lastly, a genome-wide association study conducted shared variance CT. RESULTS HbA1c–CT...
Abstract Adolescence is a period of brain maturation that may involve second wave organizational effects sex steroids on the brain. Rodent studies suggest that, overall, gonadal steroid hormones decrease from prenatal/perinatal to adulthood. Here we used multimodal magnetic resonance imaging investigate whether 1) testosterone exposure during adolescence (9–17 years) correlates with structure cerebral cortex in young men (n = 216, 19 years age); 2) this relationship modulated by timing surge...
Abstract Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet neurobiological substrates are poorly understood. Here, we used a virtual-histology technique gene expression data from Allen Human Brain Atlas compare regional profiles of longitudinal cortical through (4004 MRIs) with those for several neuronal non-neuronal cell types. The results were replicated in three independent datasets. We found that inter-regional related marker genes CA1...