Tiffany M. Chaim‐Avancini
A5048925221- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Health, Environment, Cognitive Aging
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Cognitive Abilities and Testing
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Retinal Imaging and Analysis
- Hemispheric Asymmetry in Neuroscience
- Schizophrenia research and treatment
- Fetal and Pediatric Neurological Disorders
- Spatial Neglect and Hemispheric Dysfunction
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Child Abuse and Trauma
- Substance Abuse Treatment and Outcomes
- Hypothalamic control of reproductive hormones
- Electroconvulsive Therapy Studies
- Sex and Gender in Healthcare
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2023
Universidade de São Paulo
2016-2023
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
Delineating the association of age and cortical thickness in healthy individuals is critical given with cognition behavior. Previous research has shown that robust estimates between brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 aged 3-90 years Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes thickness. We fractional polynomial (FP) regression quantify thickness, computed normalized...
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies may obscure or distort lifespan trajectories of morphometry. In response, we capitalized resources Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related inferred from cross-sectional measures ventricles, basal ganglia...
Abstract Background Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in MDD patients, whether this process clinical characteristics a large multi-center international dataset. Methods performed mega-analysis by pooling measures derived from T1-weighted MRI scans 29 samples worldwide. Normative was estimated predicting chronological age (10-75 years) 7 subcortical volumes, 34...
Diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) microstructural abnormalities in schizophrenia. Whether or not such alterations could vary depending on clinical status (i.e. acute psychosis v. remission) remains to be investigated.Twenty-five treatment-naïve first-episode (FEP) patients and 51 healthy-controls (HC) underwent MRI scanning at baseline. Twenty-one were re-scanned as soon they achieved sustained remission of symptoms; 36 HC also scanned twice....
Many previous magnetic resonance imaging (MRI) studies have documented sex differences in brain morphology, but the patterns of sexual transgender women - male assigned at birth with a diagnosis gender dysphoria (TW) been rarely investigated to date. We acquired T1-weighted MRI data for following four (n = 80) groups: treatment-naïve TW (TNTW), treated cross-sex hormones least one year (TTW), cisgender men, and (cisgender individuals as controls). Differences whole-brain regional white...
Objective In adulthood, the diagnosis of attention‐deficit/hyperactivity disorder ( ADHD ) has been subject recent controversy. We searched for a neuroanatomical signature associated with spectrum symptoms in adults by applying, first time, machine learning‐based pattern classification methods to structural MRI and diffusion tensor imaging DTI data obtained from stimulant‐naïve childhood‐onset healthy controls HC ). Method Sixty‐seven patients 66 underwent high‐resolution T1‐weighted...
Abstract Delineating age-related cortical trajectories in healthy individuals is critical given the association of thickness with cognition and behaviour. Previous research has shown that deriving robust estimates brain morphometric changes requires large-scale studies. In response, we conducted a analysis 17,075 aged 3-90 years by pooling data through Lifespan Working group Enhancing Neuroimaging Genetics Meta-Analysis (ENIGMA) Consortium. We used fractional polynomial (FP) regression to...
Studies of habenula (Hb) function and structure provided evidence its involvement in psychiatric disorders, including schizophrenia bipolar disorder. Previous studies using magnetic resonance imaging (manual/semiautomated segmentation) have reported conflicting results. Aiming to improve Hb segmentation reliability the study large datasets, we describe a fully automated protocol that was validated against manual segmentations applied 3 datasets (childhood/adolescence adult disorder...
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around world jointly analyze 10,000+ existing MRI connectivity datasets during 3-day workshop. In this report, we describe motivation and principles of public release 8,000+ connectome maps human brain.
Abstract For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents largest-ever mega-analysis of brain structure, based on international data spanning nine decades life. Subcortical volumes, cortical surface area thickness were assessed MRI 16,683 healthy individuals 1-90 years old (47% females). We observed...
Abstract Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies may obscure or distort lifespan trajectories of morphometry. In response, we capitalised resources Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related morphometric ventricles, basal ganglia (caudate, putamen,...
The severity of substance use disorder (SUD) is currently defined by the sum DSM-5 criteria. However, little known about validity this framework or role additional indicators in relapse prediction. This study aimed to investigate relationship between criteria, neurocognitive functioning, variables and cocaine among inpatients with (CUD).128 adults aged 18 45 years were evaluated; 68 (59 males, 9 females) had CUD 60 (52 8 healthy controls. For group CUD, other substances was not an exclusion...
Abstract Hemispheric asymmetry is a cardinal feature of human brain organization. Altered has also been linked to some cognitive and neuropsychiatric disorders. Here the ENIGMA consortium presents largest ever analysis cerebral cortical its variability across individuals. Cortical thickness surface area were assessed in MRI scans 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric regional levels, with generally thicker cortex...