A5013830815- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Neurogenetic and Muscular Disorders Research
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Biochemical Acid Research Studies
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- NMR spectroscopy and applications
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
University Medical Center Utrecht
2016-2022
Utrecht University
2018-2022
Cancer Genomics Centre
2020
De Hoogstraat Revalidatie
2020
Neurology, Inc
2020
Heidelberg University
2016
University Hospital Heidelberg
2016
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease, with large variation in survival between patients. Currently, it remains rather difficult to predict based on clinical parameters alone. Here, we set out use characteristics combination MRI data of ALS patients using deep learning, machine learning technique highly effective broad range big-data analyses. A group 135 was included from whom high-resolution diffusion-weighted and T1-weighted images were acquired at the...
Objective Clinical trials in amyotrophic lateral sclerosis (ALS) continue to rely on survival or functional scales as endpoints, despite the emergence of quantitative biomarkers. Neuroimaging‐based biomarkers ALS have been shown detect ALS‐associated pathology vivo, although anatomical patterns disease spread are poorly characterized. The objective this study is simulate propagation using network analyses cerebral magnetic resonance imaging (MRI) data predict progression. Methods Using brain...
To determine the prevalence and prognostic value of weight loss (WL) prior to diagnosis in patients with amyotrophic lateral sclerosis (ALS).We enrolled diagnosed ALS between 2010 2018 a population-based setting. At diagnosis, detailed information was obtained regarding patient's disease characteristics, anthropological changes, ALS-related genotypes cognitive functioning. Complete survival data were obtained. Cox proportional hazard models used assess association WL risk death during...
To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by investigating differential brain patterns gray and white matter involvement in clinically or genetically defined subgroups patients using cross-sectional, longitudinal, multimodal MRI.We assessed cortical thickness, subcortical volumes, connectivity from T1-weighted diffusion-weighted MRI 292 with ALS (follow-up: n = 150) 156 controls 72). Linear mixed-effects models were used to assess changes structural...
The purpose of this study was to identify subtypes amyotrophic lateral sclerosis (ALS) by comparing patterns neurodegeneration using brain magnetic resonance imaging (MRI) and explore their phenotypes.We performed T1-weighted diffusion tensor in 488 clinically well-characterized patients with ALS 338 control subjects. Measurements whole-brain cortical thickness white matter connectome fractional anisotropy were adjusted for disease-unrelated variation. A probabilistic network-based...
Objective The rs12608932 single nucleotide polymorphism in UNC13A is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) susceptibility, may underlie differences treatment response. We aimed to characterize the clinical, cognitive, behavioral, neuroimaging phenotype of patients ALS. Methods included 2,216 ALS without a C9orf72 mutation identify clinical characteristics polymorphism. A subcohort 428 was used study cognitive behavioral profiles, 375...
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease characterized by both upper and lower motor neuron degeneration. While neuroimaging studies of the brain can detect degeneration, these MRI scans also include part cervical spinal cord, which offers possibility to expand focus towards Here, we set out investigate cross-sectional longitudinal effects in cord patients with ALS, muscular atrophy (PMA: primarily involvement) primary (PLS: involvement), their relation...
Objective We investigated effects of C9orf72 repeat expansion and gene expression on longitudinal cerebral changes before symptom onset. Methods enrolled 79 asymptomatic family members (AFMs) from 9 families with expansion. Twenty‐eight AFMs carried the mutation (C9+). Participants had up to 3 magnetic resonance imaging (MRI) scans, after which we compared motor cortex tracts between C9+ C9− using mixed models, incorporating kinship correct for familial relations lessen other genetic...
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around world jointly analyze 10,000+ existing MRI connectivity datasets during 3-day workshop. In this report, we describe motivation and principles of public release 8,000+ connectome maps human brain.
Abstract We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around world jointly analyze 10,000+ existing MRI connectivity datasets during 3-day workshop. In this report, we describe motivation and principles of public release 8,000+ connectome maps human brain.