This study was conducted to examine the statistical influence of brain size on cortical, subcortical, and cerebellar compartmental volumes. especially studied delineate interactions with Sex Age. Here, we 856 healthy subjects which 533 are classified as young 323 old. Using an automated segmentation procedure cortical (gray white matter [GM WM] including corpus callosum), (GM WM), subcortical (thalamus, putamen, pallidum, caudatus, hippocampus, amygdala, accumbens) volumes were measured...

Previous neuroimaging studies in the field of motor learning have shown that a new skill induces specific changes neural gray and white matter human brain areas necessary to control practiced task. Former longitudinal investigating used strict training protocols with little ecological validity rather than physical leisure activities, although there are several retrospective cross-sectional suggesting neuroprotective effects activities. In present MRI study, we voxel-based morphometry...

Virtual reality (VR) offers powerful therapy options within a functional, purposeful and motivating context. Several studies have shown that patients' motivation plays crucial role in determining outcome. However, few demonstrated the potential of VR pediatric rehabilitation. Therefore, we developed VR-based soccer scenario, which provided interactive elements to engage patients during robotic assisted treadmill training (RAGT). The aim this study was compare immediate effect different...

In this study, we examined whether age can be predicted on the basis of different anatomical features obtained from a large sample healthy subjects (n = 3,144). From feature sets: (1) 11 larger brain regions (including cortical volume, thickness, area, subcortical cerebellar etc.), (2) 148 compartmental thickness measures, (3) area (4) volume and (5) combination above-mentioned measures. With these sets, using 6 statistical techniques (multiple linear regression, ridge neural network,...

Healthy aging is associated with weaker functional connectivity within resting state brain networks and stronger interaction between these networks. This phenomenon has been characterized as reduced segregation investigated mainly in cross-sectional studies. Here, we used a longitudinal dataset which consisted of four occasions fMRI psychometric cognitive ability data, collected from sample healthy older adults (baseline N = 232, age range: 64–87 y, M 70.8 y), to investigate the several...

Objective: To examine the effect of various forms training interventions, with and without virtual reality, on initiation maintenance active participation during robotassisted gait training.Design: Intervention study at Rehabilitation Centre Affoltern a. A., University Children's Hospital, Zurich.Subjects: Ten patients (5 males, mean age 12.47 years, standard deviation 1.84 years) different neurological disorders 14 healthy children (7 11.76 2.75 years).Methods: All participants walked in...

The ability to accurately process numerical magnitudes and solve mental arithmetic is of highest importance for schooling professional career. Although impairments in these domains disorders such as developmental dyscalculia (DD) are highly detrimental, remediation still sparse. In recent years, transcranial brain stimulation methods Direct Current Stimulation (tDCS) have been suggested a treatment various neurologic neuropsychiatric disorders. posterior parietal cortex (PPC) known be...

Abstract Relatively little is known about reliability of longitudinal diffusion‐tensor imaging (DTI) measurements despite growing interest in using DTI to track change white matter structure. The purpose this study quantify within‐ and between session scan‐rescan DTI‐derived measures that are commonly used describe the characteristics neural context plasticity research. data were acquired from 16 cognitively healthy older adults (mean age 68.4). We Tract‐Based Spatial Statistics (TBSS)...

Abstract Age‐related behavioral declines may be the result of deterioration white matter tracts, affecting brain structural (SC) and functional connectivity (FC) during resting state. To date, it is not clear if combination SC FC data could better predict cognitive/motor performance than each measure separately. We probed these relationships in cingulum bundle, a major pathway default mode network. aimed to attain deeper knowledge about: (a) relationship between age cingulum's strength, (b)...

We examined whether it is possible to identify individual subjects on the basis of brain anatomical features. For this, we analyzed a dataset comprising 191 who were scanned three times over period two years. Based FreeSurfer routines, generated datasets covering 148 regions (cortical thickness, area, volume). These also combined containing all these measures. In addition, used 11 composite measures for which larger (11LBR). subjected linear discriminant analysis (LDA) and weighted K-nearest...

Magnetic Resonance Imaging (MRI) studies have shown that cortical volume declines with age. Although is a multiplicative measure consisting of thickness and area, few focused on both its components. Information decline variability associations between person-specific changes different brain metrics, regions, cognition sparse. In addition, the estimates often been biased by measurement error, because three repeated measures are minimally required to separate error from changes. With sample...

Functional neuroimaging and voxel-based morphometry studies have confirmed the important role of cerebellum in motor behavior. However, little is known about relationship between cerebellar gray (GMv) white matter (WMv) volume manual performance aging individuals. This study aims to quantify tissue performance.To gain more insight into function how it relates primary cortex (M1), we related GMv, WMv, M1v 217 healthy older Left right GMv were obtained using FreeSurfer. The following measures...

There is no doubt that good bimanual performance very important for skilled handball playing. The control of the non-dominant hand especially demanding since efficient catching and throwing needs both hands.We investigated training-induced structural neuroplasticity in professional players using several neuroimaging techniques analytic approaches also provide a review literature about sport-induced neuroplastic alterations. Structural brain adaptations were expected regions relevant motor...

Healthy aging is associated with changes in cognitive performance and functional brain organization. In fact, cross-sectional studies imply lower modularity significant heterogeneity modular architecture across older subjects. Here, we used a longitudinal dataset consisting of four occasions resting-state-fMRI testing (spanning 4 years) 150 healthy adults. We applied graph-theoretic analysis to investigate the time-evolving structure whole-brain network, by maximizing multilayer time points....

Multi-domain training potentially increases the likelihood of overlap in processing components with transfer tasks and everyday life, hence is a promising approach for older adults. To empirically test this, 84 healthy adults aged 64 to 75 years were randomly assigned one three single-domain conditions (inhibition, visuomotor function, spatial navigation) or simultaneous all cognitive functions (multi-domain condition). All participants trained on an iPad at home 50 sessions. Before after...

Finding effective training interventions for declining cognitive abilities in healthy aging is of great relevance, especially view the demographic development. Since it assumed that transfer from trained to untrained domains more likely occur when conditions and measures share a common underlying process, multi-domain several functions should increase likelihood such an overlap. In first part, we give overview literature showing using complex tasks, as video games, leisure activities, or...

Cross-sectional studies have consistently identified age-associated alterations in default mode network (DMN) functional connectivity (FC). Yet, research on longitudinal trajectories of FC changes the DMN healthy aging is less conclusive. For present study, we used a resting state MRI dataset drawn from Longitudinal Healthy Aging Brain Database Project (LHAB) collected 5 occasions over course 7 years (baseline N = 232, age range: 64-87 y, mean 70.85 y). strength within and its regions were...

The key objective of the International Normal Aging and Plasticity Imaging Center (INAPIC) at University Zürich is to facilitate research on normal healthy behavioral neural development aging explore potential for plasticity compensation across lifespan. INAPIC invites international groups submit proposals collaborative projects these subjects. It unique in Europe giving partner ‘plug play’ access state-of-the-art neuroimaging techniques, technical support, assistance data collection. This...

Much is known about practice-induced plasticity of the motor system. But it not clear how a physical training influences mental rehearsal practiced task and its associated hemodynamic responses. In present longitudinal study with two measurement time-points, we used method functional magnetic resonance imaging (fMRI) imagery task, in order to explore dynamic neuro-functional changes induced by highly complex training. The 11 golf novices between age 40 60 years as leisure activity....

Aging is associated with microstructural white matter (WM) changes. WM characteristics, measured diffusion tensor imaging (DTI), are different in normal appearing (NAWM) and hyperintensities (WMH). It largely unknown how the properties of WMH cognition if there regional effects for specific cognitive domains. We therefore examined within 200 healthy older participants a) differences characteristics NAWM per cerebral lobe; b) association macrostructural (WMH volume) (within separately) each...