Xavier Caseras
A5060974390- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Personality Disorders and Psychopathology
- Health, Environment, Cognitive Aging
- Genetics and Neurodevelopmental Disorders
- Personality Traits and Psychology
- Neural and Behavioral Psychology Studies
- Genomic variations and chromosomal abnormalities
- Schizophrenia research and treatment
- Eating Disorders and Behaviors
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Congenital heart defects research
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Attention Deficit Hyperactivity Disorder
- Body Image and Dysmorphia Studies
- Alzheimer's disease research and treatments
- Genomics and Rare Diseases
Cardiff University
2016-2025
Humboldt-Universität zu Berlin
2024
Medical Research Council
2016-2022
Centre for Mental Health
2021
Mental Health Research Institute
2020
Genomics (United Kingdom)
2019
Universitat Autònoma de Barcelona
2004-2014
King's College London
2007-2012
Universitat Pompeu Fabra
2012
University of Southampton
2007
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying sources of can help generate novel clinical hypotheses etiology assist in development biomarkers for indexing disease progression prognosis. Here we were interested case-control differences intracranial volume (ICV) each eight subcortical measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
Delineating the association of age and cortical thickness in healthy individuals is critical given with cognition behavior. Previous research has shown that robust estimates between brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 aged 3-90 years Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes thickness. We fractional polynomial (FP) regression quantify thickness, computed normalized...
Little is known about the neurobiology of bipolar II disorder. While I disorder associated with abnormally elevated activity in response to reward ventral striatum, a key component circuitry, no studies have compared circuitry function and disorders. Furthermore, associations among activity, sensitivity, striatal volume remain underexplored healthy individuals. The authors examined striatum participants disorders individuals, relationships between sensitivity across all participants,...
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies may obscure or distort lifespan trajectories of morphometry. In response, we capitalized resources Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related inferred from cross-sectional measures ventricles, basal ganglia...
The study investigated biases for negative information in component processes of visual attention (initial shift vs. maintenance gaze) dysphoric and nondysphoric individuals. Eye movements were recorded while participants viewed a series picture pairs depicting negative, positive, neutral scenes (each pair presented 3 s). Biases initial orienting assessed from the direction latency gaze, whereas duration gaze on that was initially fixated. Results indicated group showed significantly greater...
Objectives Emotion regulation deficits are a core feature of bipolar disorder. However, their potential neurobiological underpinnings and existence beyond I disorder remain unexplored. Our main goal was to investigate whether both individuals with II show in emotion during an attention control task, explore the neurophysiological this deficit. Methods Twenty healthy controls, 16 euthymic participants disorder, 19 completed psychometric clinical assessments, neuroimaging paradigm, anatomical...
BackgroundRecent genome-wide association studies have identified genetic loci that jointly make a considerable contribution to risk of developing Alzheimer's disease (AD). Because neuropathological features AD can be present several decades before onset, we investigated whether effects polygenic are detectable by neuroimaging in young adults. We hypothesized higher scores (PRSs) for would associated with reduced volume the hippocampus and other limbic paralimbic areas. further PRSs affect...
The Personality Inventory for DSM-5 (PID-5) measures the trait part (Criterion B) of alternative model personality disorders proposed in Section III DSM-5. Although its psychometric properties have proven adequate thus far, evidence is limited other languages and clinical samples. Spanish PID-5 was examined two samples comprising 446 1,036 community subjects. Facet scales showed good internal consistency both (median α = .86 .79) were unidimensional under exploratory confirmatory approaches....
Although cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD), few reliable predictors of outcome have been identified. The present study examined the neural correlates symptom improvement with CBT among OCD patients predominantly contamination obsessions and washing compulsions, most common dimension.Participants consisted 12 who underwent provocation contamination-related images during functional magnetic resonance imaging (fMRI) scanning...
FMRI BOLD responses to changes in neural activity are influenced by the reactivity of vasculature. By complementing a task-related acquisition with vascular measure obtained through breath-holding or hypercapnia, this unwanted variance can be statistically reduced interest. Recently, it has been suggested that also estimated using resting state scan. This study aimed compare three breath-hold based analysis approaches (block design, sine–cosine regressor and CO2 regressor) approach (CO2...
BackgroundAlterations in functional connectivity between the nucleus accumbens (NAcc) and frontal cortices have been previously associated with presence of psychiatric syndromes, including bipolar disorder (BD). Whether these alterations are a consequence or risk factor for mental disorders remains unresolved.MethodsThis study included 35 patients BD, 30 nonaffected siblings 23 healthy control subjects to probe at rest NAcc brain cross-sectional design. Blood oxygen level–dependent time...
Schizophrenia is a highly heritable disorder for which anatomical brain alterations have been repeatedly reported in clinical samples. Unaffected at-risk groups also studied an attempt to identify changes that do not reflect reverse causation or treatment effects. However, no robust associations observed between neuroanatomical phenotypes and known genetic risk factors schizophrenia. We tested subcortical volume differences 49 unaffected participants carrying at least one of the 12 copy...