Marco Hermesdorf
A5075742830- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Health, Environment, Cognitive Aging
- Traumatic Brain Injury Research
- Child Abuse and Trauma
- Mental Health Research Topics
- Amyotrophic Lateral Sclerosis Research
- Treatment of Major Depression
- Sex and Gender in Healthcare
- Sleep and related disorders
- Dementia and Cognitive Impairment Research
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Suicide and Self-Harm Studies
- Diet and metabolism studies
- LGBTQ Health, Identity, and Policy
- Restless Legs Syndrome Research
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Dysphagia Assessment and Management
- Diet, Metabolism, and Disease
- Child and Adolescent Psychosocial and Emotional Development
- Peripheral Neuropathies and Disorders
University of Münster
2015-2024
University Hospital Münster
2022
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
There is a lack of validated biomarkers for disability progression independent relapse activity (PIRA) in multiple sclerosis (MS).
Abstract Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between and structure using structural MRI ( n = 6420) genetic data 3907) from ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical subcortical abnormalities in both mass-univariate multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found...
Abstract Background Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in MDD patients, whether this process clinical characteristics a large multi-center international dataset. Methods performed mega-analysis by pooling measures derived from T1-weighted MRI scans 29 samples worldwide. Normative was estimated predicting chronological age (10-75 years) 7 subcortical volumes, 34...
Abstract Depression has been associated with various alterations in magnetic resonance imaging (MRI) derived resting‐state functional connectivity. Recently, homotopic connectivity, defined as connectivity between regions across hemispheres, reported to be reduced patients major depressive disorder (MDD). However, little is known about structural factors underlying of which would contribute the understanding altered neurophysiological architecture MDD. We compared 368 MDD and 461...
Objective To investigate the longitudinal dynamics of serum glial fibrillary acidic protein (sGFAP) and neurofilament light chain (sNfL) levels in people with multiple sclerosis (pwMS) under B‐cell depleting therapy (BCDT) their capacity to prognosticate future progression independent relapse activity (PIRA) events. Methods A total 362 pwMS (1,480 samples) starting BCDT Swiss Multiple Sclerosis (MS) Cohort were included. sGFAP 2,861 control persons (4,943 provided normative data calculate...
Importance: Major depressive disorder (MDD) is highly heterogeneous, with marked individual differences in clinical presentation and neurobiology, which may obscure identification of structural brain abnormalities MDD. To explore this, we used normative modeling to index regional patterns variability cortical thickness (CT) across patients. Objective: use a large dataset from the ENIGMA MDD consortium obtain individualised CT deviations norm (relative age, sex site) examine relationship...
Neurofilament light is a constituent of the neuronal cytoskeleton and released into blood following neuro-axonal damage. It has previously been reported that NfL measured in serum inversely related to body mass index. However, no reports exist with regard composition assessed using bioelectrical impedance analysis or other indicators obesity beyond BMI. We analyzed relationship between sNfL according three compartment model. Additionally, associations sNfL, shape index, waist-to-height...
Previous studies revealed several alterations of the cerebral white matter in patients with major depressive disorder. However, it is unknown if these are associated vascular changes brain and other body parts. We compared diffusion tensor imaging derived fractional anisotropy a well characterized sample middle-aged disorder (n = 290) never-depressed controls 346) by method tract-based spatial statistics. Subsequently, potential role pulse wave velocity as mediator depression- age-related...
Abstract Transgender individuals (TIs) show brain-structural alterations that differ from their biological sex as well perceived gender. To substantiate evidence the brain structure of TIs differs male and female, we use a combined multivariate univariate approach. Gray matter segments resulting voxel-based morphometry preprocessing N = 1753 cisgender (CG) healthy participants were used to train ( 1402) validate (20% holdout 351) support-vector machine classifying sex. As second validation,...
Abstract Study Objectives Sleep is essential for restorative metabolic changes and its physiological correlates can be examined using overnight polysomnography. However, the association between sleep characteristics brain structure not well understood. We aimed to investigate gray matter volume cognitive performance related characteristics. Methods Polysomnographic recordings from 190 community-dwelling participants were analyzed with a principal component analysis in order identify...
Abstract Study Objectives Even though numerous studies indicate that sleep disorders are associated with altered brain morphology, MRI focusing on periodic limb movements in (PLMS) scarce. Our aim was to investigate the association of PLMS global and regional gray matter volumes as well white hyperintensity (WMH) volume. Methods One hundred eighty-nine subjects (57.0 ± 7.8 years, women: 50.5%) population-based BiDirect underwent a single-night polysomnography (PSG). Standard criteria...
Abstract Neurofilament light polypeptide (NfL) is a component of the neuronal cytoskeleton and particularly abundant in large-caliber axons. When axonal injury occurs, NfL released reaches cerebrospinal fluid blood. Associations between white matter alterations have previously been observed studies based on patients with neurological diseases. The current study aimed to explore relationship serum (sNfL) characteristics population-based sample. cross-sectional associations sNfL as dependent...
Objective: Previous studies on patients with Restless Legs Syndrome (RLS) yielded inconclusive results in the MRI-based analyses of alterations subcortical structures brain. The aim this study was to compare volumes as well shapes and hippocampus between RLS cases controls. Additionally, associations genetic risks for were investigated. Methods: We compared volumetric shape differences assessed by 3 tesla magnetic resonance imaging caudate nucleus, hippocampus, globus pallidus, putamen...
A key objective in the field of translational psychiatry over past few decades has been to identify brain correlates common individuals with major depressive disorder (MDD). Identifying measurable indicators processes associated MDD could facilitate detection at risk, and development novel treatments, monitoring treatment effects, predicting who might benefit most from treatments that target specific mechanisms. However, despite intensive neuroimaging research towards this effort,...
SUMMARY Background Suicidal behavior is highly heterogeneous and complex. A better understanding of its biological substrates mechanisms could inform the design more effective suicide prevention intervention strategies. Neuroimaging studies suicidality have so far been conducted in small samples, prone to biases false-positive associations, yielding inconsistent results. The ENIGMA-MDD working group aims address issues poor replicability comparability by coordinating harmonized analyses...
The dicarbonyl compounds methylglyoxal (MG), glyoxal (GO) and 3-deoxyglucosone (3-DG) have been linked to various diseases. However, disease-independent phenotypic genotypic association studies with phenome-wide genome-wide reach, respectively, not provided. MG, GO 3-DG were measured by LC-MS in 1304 serum samples of two populations (KORA, n = 482; BiDirect, 822) assessed for associations SNPs (GWAS) traits. Redundancy analysis (RDA) was used identify major independent trait associations....
Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, and recent reports questioned the replicability of mental health neuroimaging findings. Here, we investigate correlates (measured retrospectively via Trauma Questionnaire) across three large adult cohorts (total N=3225). Pooling revealed maltreatment-related reductions, with most extensive when not controlling...