A5089360501- Growth Hormone and Insulin-like Growth Factors
- Advanced Glycation End Products research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Thyroid Disorders and Treatments
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Aortic Disease and Treatment Approaches
- Mental Health Research Topics
- Neurological Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Circadian rhythm and melatonin
- Metabolomics and Mass Spectrometry Studies
- Dietary Effects on Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
University of Lübeck
2023-2024
German Centre for Cardiovascular Research
2023-2024
Social Neuroscience Lab
2024
In recent years, the gut microbiota and derived metabolites have emerged as relevant players in modulating several brain functions, including energy balance control1-3. This form of distant communication mirrors that metabolic hormones (for example, leptin, ghrelin), which convey information about organism's status by exerting effects on diverse regions, master homeostatic centre, hypothalamus4. However, whether hypothalamus is also able to influence composition remains enigmatic. Here we...
Monomethyl fumarate (MMF) and its prodrug dimethyl (DMF) are currently the most widely used agents for treatment of multiple sclerosis (MS). However, not all patients benefit from DMF. We hypothesized that variable response may be due to their diet. In support this hypothesis, mice subjected experimental autoimmune encephalomyelitis (EAE), a model MS, did DMF when fed lauric acid-rich (LA) Mice on normal chow (NC) diet, in contrast, even more so high-fiber (HFb) diet showed expected...
Complications of diabetes are often attributed to glucose and reactive dicarbonyl metabolites derived from glycolysis or gluconeogenesis, such as methylglyoxal. However, in the CNS, neurons endothelial cells use lactate energy source addition glucose, which does not lead formation methylglyoxal has previously been considered a safer route consumption than glycolysis. Nevertheless, hotspots for cellular pathology underlying neurological complications diabetes, suggesting cause that is...
Abstract Thyroid hormones (THs) are critical regulators of systemic energy metabolism and homeostasis. In the liver, high TH action protects against steatosis by enhancing cholesterol triglyceride turnover, with thyroid hormone receptor beta (THRB) signaling playing a pivotal role. This study probed potential interaction between THRB another regulator liver metabolism, circadian clock. Liver transcriptome analysis deficient (THRB KO ) mice under normal chow conditions revealed modest impact...
The increasing prevalence of depression requires more effective therapy and the understanding antidepressants' mode action. We carried out untargeted metabolomics prefrontal cortex rats exposed to chronic social isolation (CSIS), a rat model depression, and/or fluoxetine treatment using liquid chromatography-high resolution mass spectrometry. behavioral phenotype was assessed by forced swim test. To analyze data, we employed univariate multivariate analysis biomarker capacity assessment...
Abstract Background Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even the absence of pre-existing diabetes. However, clinical trials treatment elevated glucose levels with insulin did not improve outcome, suggesting that collateral effects rather than hyperglycaemia itself aggravate brain damage. As reactive metabolites, glyoxal methylglyoxal are candidates for mediating deleterious stroke. Methods In 135 patients stroke, we used liquid chromatography...
It is well established that maternal thyroid hormones play an important role for the developing fetus; however, consequences of hyperthyroidism offspring remain poorly understood. Here we show in mice 3,3',5-triiodothyronine (T3) treatment during pregnancy leads to improved glucose tolerance adult male and hyperactivity brown adipose tissue (BAT) thermogenesis both sexes starting early after birth. The activated BAT provides advantages upon cold exposure, reducing strain on other thermogenic...
The increasing prevalence of depression worldwide requires more effectiveness in therapy approaches and a molecular understanding antidepressants mode action. We carried out untargeted metabolomics the prefrontal cortex rats exposed to chronic social isolation (CSIS), rat model depression, and/or fluoxetine treatment using liquid chromatography-high resolution mass spectrometry. behavioral phenotype was assessed by forced swim test. To analyze data, univariate multivariate analysis biomarker...
Snacking, i.e., the intake of small amounts palatable food items, is a common behavior in modern societies, promoting overeating and obesity. Shifting into daily rest phase disrupts circadian rhythms also known to stimulate weight gain. We therefore hypothesized that chronic snacking inactive may promote body gain this effect based on disruption clocks.Male mice were fed chocolate snack either during their or active development metabolic parameters investigated. Snacking experiments repeated...
Thyroid hormones (THs) are critical regulators of systemic energy metabolism and homeostasis. In the liver, high TH action protects against steatosis by enhancing cholesterol triglyceride turnover, with thyroid hormone receptor beta (THRB) signaling playing a pivotal role. This study probed potential interaction between THRB another regulator liver metabolism, circadian clock. Liver transcriptome analysis deficient (THRBKO) mice under normal chow conditions revealed markedly modest impact...
The dicarbonyl compounds methylglyoxal (MG), glyoxal (GO) and 3-deoxyglucosone (3-DG) have been linked to various diseases. However, disease-independent phenotypic genotypic association studies with phenome-wide genome-wide reach, respectively, not provided. MG, GO 3-DG were measured by LC-MS in 1304 serum samples of two populations (KORA, n = 482; BiDirect, 822) assessed for associations SNPs (GWAS) traits. Redundancy analysis (RDA) was used identify major independent trait associations....
Metabolic perturbation has been associated with depression. An untargeted metabolomics approach using liquid chromatography-high resolution mass spectrometry was employed to detect and measure the rat serum metabolic changes following chronic social isolation (CSIS), an animal model of depression, effective antidepressant fluoxetine (Flx) treatment. Univariate multivariate statistics were used for data analysis differentially expressed metabolites (DEMs) determination. Potential markers...
Abstract Background Aortic stenosis due to calcific aortic valve disease (CAVD) is the most common valvular heart disease. In symptomatic patients, without repair prognosis poor. Treatment date based on surgery or catheter-based interventions. Pharmacological therapy options prevent progression of calcification are not available. vascular smooth muscle cells, cellular accumulation sphingolipids associated with a proinflammatory response in sense lipotoxicity. Chronic inflammatory processes...