A5055064257- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Neuropeptides and Animal Physiology
- Diet, Metabolism, and Disease
- Eating Disorders and Behaviors
- Thyroid Disorders and Treatments
- Neuroscience of respiration and sleep
- Hormonal Regulation and Hypertension
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Lysosomal Storage Disorders Research
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Trypanosoma species research and implications
German Center for Diabetes Research
2016-2025
Heinrich Heine University Düsseldorf
2016-2025
Deutsches Diabetes-Zentrum e.V.
2016-2025
Ludwig-Maximilians-Universität München
2023-2025
Helmholtz Zentrum München
2016-2025
Technical University of Munich
2012-2023
University of Tübingen
2019-2022
Center for Environmental Health
2012-2022
Anton Paar (Austria)
2021
Institute of Bioinformatics and Systems Biology
2020
Compared to best-in-class GLP-1 mono-agonists, unimolecular co-agonists of and GIP with optimized pharmacokinetics enhance glycemic metabolic benefits in mammals.
Background Obesity is a major health problem. Although heritability substantial, genetic mechanisms predisposing to obesity are not very well understood. We have performed genome wide association study (GWA) for early onset (extreme) obesity. Methodology/Principal Findings a) GWA (Genome-Wide Human SNP Array 5.0 comprising 440,794 single nucleotide polymorphisms) extreme based on 487 extremely obese young German individuals and 442 healthy lean controls; b) confirmatory analyses 644...
Article1 March 2019Open Access Transparent process Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease Lili Niu Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University Copenhagen, Denmark Department Proteomics and Signal Transduction, Max Planck Institute Biochemistry, Martinsried, Germany Search more papers by this author Philipp E Geyer Nicolai J Wewer Albrechtsen orcid.org/0000-0003-4230-5753 Biomedical...
Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism and promotes weight loss, as reflected by the wasting observed in glucagonoma patients. Recently, coagonist peptides that include glucagon agonism have emerged promising therapeutic candidates for treatment obesity diabetes. We developed a novel stable soluble receptor (GcgR) agonist, which allowed vivo dissection action. As expected, chronic GcgR mice resulted hyperglycemia lower body fat plasma...
Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but physiological relevance CNS remains unknown. Here we show that HFD-fed CNS-Gipr KO mice and humanized (h)GIPR knockin with CNS-hGIPR deletion decreased body weight improved glucose metabolism. In DIO mice, acute central peripheral administration acyl-GIP increases cFos...
Abstract The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) mediate insulin responses that are proportionate to nutrient intake facilitate glucose tolerance . GLP-1 receptor (GLP-1R) is an established drug target for the treatment of diabetes obesity 2 , whereas therapeutic potential GIP (GIPR) a subject debate. Tirzepatide agonist at both GIPR GLP-1R highly effective type 3,4 However, although tirzepatide activates in cell lines mouse...
Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling (phospho)proteomics, revealed AdEVs transfer functional insulinotropic protein cargo into pancreatic β-cells. Upon transfer, AdEV proteins were subjects for phosphorylation, augmented GPCR/cAMP/PKA signaling by increasing total...