A5010177478- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Pharmacology and Obesity Treatment
- Hormonal Regulation and Hypertension
- Eating Disorders and Behaviors
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Diabetes and associated disorders
- Stress Responses and Cortisol
- Exercise and Physiological Responses
- Obesity, Physical Activity, Diet
- Adrenal Hormones and Disorders
- Neurobiology and Insect Physiology Research
- Genetic Syndromes and Imprinting
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
- Bariatric Surgery and Outcomes
- Genetic Associations and Epidemiology
- Nicotinic Acetylcholine Receptors Study
Helmholtz Zentrum München
2016-2024
Technical University of Munich
2016-2021
German Center for Diabetes Research
2016-2019
Heinrich Heine University Düsseldorf
2016-2019
Deutsches Diabetes-Zentrum e.V.
2016-2019
Genomics (United Kingdom)
2017
Collaborative Group (United States)
2016
Children's Hospital of Philadelphia
2016
Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies typically first evaluated in male mouse models diet-induced obesity (DIO). To address disparity we herein determined whether monomeric peptide with agonism at the receptors for glucagon-like 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon equally efficient correcting DIO, dyslipidemia, glucose metabolism DIO female mice as it has been...
Glucocorticoids (GCs) are important regulators of systemic energy metabolism, and aberrant GC action is linked to metabolic dysfunctions. Yet, the extent which normal pathophysiological metabolism depend on receptor (GR) in adipocytes remains unclear. Here, we demonstrate that adipocyte GR deficiency mice significantly impacts different energetic states. Plasma metabolomics biochemical analyses revealed a marked global effect metabolite abundance and, thus, substrate partitioning fed fasted...
Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity strategy. Here, we report that pharmacological activation the cold receptor transient potential cation channel subfamily M member 8 (TRPM8) with agonist icilin mimics metabolic benefits exposure. In diet-induced obese (DIO) mice, treatment enhances expenditure, and decreases body weight, without affecting food intake. To further...
Abstract Aims Unimolecular peptides targeting the receptors for glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) (GLP‐1/GIP co‐agonist) have been shown to outperform each single peptide in treatment of obesity cardiometabolic disease preclinical clinical trials. By combining physiological endpoints with plasma proteomic profiling (PPP), we aimed identify biomarkers advance non‐invasive metabolic monitoring compound success exploration ulterior effects on...
The C-terminal binding protein 2 (CTBP2) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-trait analysis of genome-wide association studies for anorexia nervosa (AN) and body mass index (BMI). Here, we did mutation in CTBP2 performing polymerase chain reactions with subsequent Sanger-sequencing to identify variants relevant AN weight regulation ensued functional studies. Analysis the coding regions 462 female patients (acute or recovered), 490 children...
Abstract Aims/hypothesis Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose tolerance in diet-induced obese (DIO) mice, but physiological and molecular mechanisms are unknown. Methods DMPP (10 mg/kg body weight, s.c.) was administered either a single injection (acute) or daily for up to 14 days (chronic) DIO wild-type (WT) Chrnb4 knockout (KO) mice tolerance, tissue-specific tracer-based metabolism,...
The contribution of brown adipose tissue (BAT) to adult human metabolic control is a topic ongoing investigation. In context, understanding the cellular events leading BAT uncoupling, heat production, and energy expenditure anticipated produce significant insight into this endeavor. phosphoinositide interacting regulator transient receptor potentials (Pirt) was recently put forward as key protein regulating cold sensing downstream potential melastatin 8 (TRPM8). Notably, TRPM8 has been...
Zusammenfassung Die weltweite Prävalenz von morbid gesteigertem Körpergewicht hat im 21. Jahrhundert epidemische Ausmaße angenommen. Adipositas gehört zu den wichtigsten Risikofaktoren für die Entstehung Diabetes mellitus Typ 2, kardiovaskulären Erkrankungen und bestimmten Tumorleiden. Entwicklung neuer individueller pharmakologischer Therapieoptionen ist größtem gesellschaftlichen Interesse, um der wachsenden Belastung unserer Gesundheitssysteme wirksam begegnen. Konservative Behandlungen,...
This experimental mouse study examined whether or not dedifferentiated β cells could be reversed targeted by pharmacological intervention for diabetes remission. They identified evidence β-cell dedifferentiation and dysfunction which single combined approaches.