A5065984673- Adipose Tissue and Metabolism
- Advanced Glycation End Products research
- Adipokines, Inflammation, and Metabolic Diseases
- Salmonella and Campylobacter epidemiology
- Food Safety and Hygiene
- Biochemical effects in animals
- Amyotrophic Lateral Sclerosis Research
- Regulation of Appetite and Obesity
- Natural Antidiabetic Agents Studies
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Alcohol Consumption and Health Effects
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Listeria monocytogenes in Food Safety
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Asthma and respiratory diseases
- Proteoglycans and glycosaminoglycans research
- Mangiferin and Mango Extracts
- Behavioral and Psychological Studies
- Circadian rhythm and melatonin
New York University
2018-2024
Doctors Hospital at Renaissance
2023-2024
Icahn School of Medicine at Mount Sinai
2015-2023
New York Proton Center
2023
International Center for Tropical Agriculture
2021
NYU Langone Health
2020
The Graduate Center, CUNY
2019
Regeneron (United States)
2019
City University of New York
2019
Queens College, CUNY
2009-2014
Abstract Introduction Epidemiologic studies have demonstrated an association between diabetes and dementia. Insulin signaling within the brain, in particular hypothalamus regulates carbohydrate, lipid, branched chain amino acid (BCAA) metabolism peripheral organs such as liver adipose tissue. We hypothesized that cerebral amyloidosis impairs central nervous system control of through disruption insulin hypothalamus, which dysregulates glucose BCAA homeostasis resulting increased...
ABSTRACT Lymph nodes (mandibular, mesenteric, mediastinal, and subiliac; n = 68) fecal ( hide 35) samples were collected from beef carcasses harvested in an abattoir Mexico. Samples analyzed for Salmonella , presumptive colonies subjected to latex agglutination. Of the isolates recovered, a subset of 91 was characterized by serotyping, pulsed-field gel electrophoresis (PFGE), antimicrobial susceptibility phenotyping. isolated 100% (hide), 94.1% (feces), 91.2% (mesenteric), 76.5% (subiliac),...
Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis. Here, we study the function synaptic connectivity of input from DMH cholinergic neurons to sympathetic premotor raphe pallidus (Rpa).In order selectively manipulate neuron activity, generated transgenic mice expressing channelrhodopsin fused yellow fluorescent protein (YFP) (choline...
Cooking time of the common bean is an important trait for consumer preference, with implications nutrition, health, and environment. For efficient germplasm improvement, breeders need more information on genetics to identify fast cooking sources good agronomic properties molecular breeding tools. In this study, we investigated a broad genetic variation among tropical from both Andean Mesoamerican genepools. Four populations were evaluated (CKT), water absorption capacity (WAC), seed weight...
Exquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon excess. In human and murine adipose tissue, the accumulation ligands receptor for advanced glycation end products (RAGE) accompanies obesity, implicating this in metabolism. Here, we demonstrate that mice bearing global- or adipocyte-specific deletion Ager, gene encoding RAGE, display superior recovery after fasting, a cold challenge, high-fat feeding. The RAGE-dependent...
Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The receptor advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate diseased spinal cord and RAGE has been previously implicated progression pathology.We generated a novel mouse model temporally delete Ager from murine SOD1G93A ALS. Microglia deficient mice controls were examined changes survival, motor...
Abstract Background/objectives The incidence of obesity continues to increase worldwide and while the underlying pathogenesis remains largely unknown, nutrient excess, manifested by “Westernization” diet reduced physical activity have been proposed as key contributing factors. Western-style diets, in addition higher caloric load, are characterized excess advanced glycation end products (AGEs), which linked pathophysiology related cardiometabolic disorders. AGEs can be “trapped” adipose...
Abstract Objective Optimal body mass and composition as well metabolic fitness require tightly regulated interconnected mechanisms across tissues. Disturbances in these regulatory networks tip the balance between health versus overweight obesity their complications. The authors previously demonstrated roles for receptor advanced glycation end products (RAGE) obesity, global‐ or adipocyte‐specific deletion of Ager (the gene encoding RAGE) protected mice from high‐fat diet‐induced dysfunction....
Abstract This study used behavioral skills training (BST) and general‐case (GCT) in which the experimenter simulated child performance to teach three staff conduct NLP response chaining increase three‐link vocal chains children with autism. Staff increased their correct during post‐training comparison baseline. Two of emitted more following training. demonstrated that BST GCT were effective chaining. When assessing social validity, both Board Certified Behavior Analysts (BCBAs) teachers did...
Insulin resistance and type 2 diabetes mellitus (T2D) are associated with increased risk for cognitive impairment, Alzheimer's disease (AD) vascular dementia. SORCS1 encodes a protein-sorting molecule genetically linked to both T2D AD. The association of AD is sexually dimorphic in humans, associations showing more robust effects females. Based on published evidence that manipulation the mouse genome combining multiple genes related cerebral amyloidosis, T2D, or both, might provide novel...
Inflammation contributes to the development of metabolic and cardiovascular disease. Cushing's disease (CD), a state chronic glucocorticoid (GC) excess characterized by visceral obesity insulin resistance, may be associated with increased systemic inflammation. Cardiovascular mortality in CD remains elevated even after successful remission. It is unclear whether low-grade inflammatory persists remission CD, which account for CVD mortality.(1) To assess circulating proinflammatory cytokines...
Abstract Fundamental modulation of energy metabolism in immune cells is increasingly being recognized for the ability to impart important changes cellular properties. In homeostasis, innate system, such as monocytes, macrophages and dendritic (DCs), are enabled respond rapidly various forms acute environmental stress, pathogens. chronic stress milieus, these may undergo a re-programming, thereby triggering processes that instigate tissue damage failure resolution. settings metabolic...
Pleiotrophin (PTN) is an extracellular matrix-associated protein with neurotrophic and neuroprotective effects that involved in a variety of neurodevelopmental processes. Data regarding the cognitive-behavioral neuroanatomical phenotype pleiotrophin knockout (KO) mice limited. The purpose this study was to more fully characterize phenotype, emphasis on domains learning memory, flexibility, exploratory behavior anxiety, social behavior, neuronal vascular microstructure lateral entorhinal...
Circulating branched-chain amino acids (BCAAs) are elevated in obesity and diabetes, recent studies support a causal role for BCAAs insulin resistance defective glycemic control. The physiological mechanisms underlying BCAA regulation poorly understood. Here we show that signaling the mediobasal hypothalamus (MBH) of rats is mandatory lowering plasma BCAAs, most probably by inducing hepatic catabolism. Insulin receptor deletion only agouti-related protein (AgRP)–expressing neurons (AgRP...
O besity and diabetes mellitus remain the leading causes of reduced health span life throughout world.Hence, it is not surprising that these areas are at center highly active research.The identification novel mechanisms underlying metabolic disorders sets stage for uncovering new potential therapeutic strategies.In this issue highlights in Arteriosclerosis, Thrombosis, Vascular Biology (ATVB), we review recently published papers journal add to our understanding consequences obesity how...
Administration of dextran sodium sulfate (DSS) to rodents at varying concentrations and exposure times is commonly used model human inflammatory bowel disease (IBD). Currently, the criteria assess IBD-like pathology seldom include surrogate measures visceral pain. Thus, we sought standardize then identify effects on We various 4% DSS protocols evaluated weight loss, colon pathology, biochemistry, RNA signature, open field behavior. tested therapeutic potential NPY Y1 and/or Y2 receptor...
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that generally arises in the maxilla during first year life. Involvement bones cranial vault or brain extremely rare. We describe 7-month-old black female who presented after falling out bed onto concrete floor. Subsequently, she developed an anterior frontal mass enlarged over several days. Radiographs skull at her local hospital showed depressed right fracture. However, computerized tomography head (reviewed our...