A5015114393- Invertebrate Immune Response Mechanisms
- Animal Behavior and Reproduction
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Insect symbiosis and bacterial influences
- Gene Regulatory Network Analysis
- Aquaculture disease management and microbiota
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Biomarkers in Disease Mechanisms
- Cancer-related molecular mechanisms research
- Plant nutrient uptake and metabolism
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- interferon and immune responses
- Physiological and biochemical adaptations
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Liver Disease Diagnosis and Treatment
New York University
2024-2025
Cornell University
2017-2024
Pediatrics and Genetics
2018-2021
ORCID
2020
VIB-UGent Center for Plant Systems Biology
2017
Abstract Maize is the highest yielding cereal crop grown worldwide for grain or silage. Here, we show that modulating expression of maize PLASTOCHRON1 ( ZmPLA1 ) gene, encoding a cytochrome P450 (CYP78A1), results in increased organ growth, seedling vigour, stover biomass and seed yield. The engineered trait robust as it improves yield an inbred well panel hybrids, at several locations over multiple seasons field. Transcriptome studies, hormone measurements auxin responsive DR5rev:mRFPer...
Abstract Background Immune responses need to be initiated rapidly, and maintained as needed, prevent establishment growth of infections. At the same time, resources balanced with other physiological processes. On level transcription, studies have shown that this balancing act is reflected in tight control initiation kinetics shutdown dynamics specific immune genes. Results To investigate genome-wide expression trade-offs after infection at a high temporal resolution, we performed an RNA-seq...
Sex peptide (SP), a seminal fluid protein of
Significance In many species, mating induces physiological changes in the female that increase reproductive success of pair. The postmating response (PMR) is caused by male seminal fluid proteins interacting with system. Because importance PMR insect species relevant to human health and agriculture, we examined gene expression profile one important cell type gland produces most Drosophila. Interestingly, among necessary for this discovered a micropeptide encoded supposedly noncoding...
The discovery of long non-coding RNAs (lncRNAs) has provided a new perspective on the centrality RNA in gene regulation and genome organization. Here, we screened for lncRNAs with putative functions host response to single-stranded respiratory viruses. We identify CARINH as conserved cis-acting lncRNA up-regulated three diseases control expression its antisense IRF1 , key transcriptional regulator antiviral response. are coordinately increased circulation patients infected human...
Mating induces a multitude of changes in female behavior, physiology, and gene expression. Interactions between male genotype lead to variation post-mating phenotypes reproductive success. So far, few molecules responsible for these interactions have been identified. Here, we used Drosophila melanogaster from 5 geographically dispersed populations investigate such × genotypic at the transcriptomic phenotypic levels. Females each line were singly-mated males same lines, total 25 combinations....
Abstract There is extensive variation in males for sperm competitive abilities, and females the ability to distinguish among from different males. But it still not known how males... In many species, can remain viable reproductive tract of a female well beyond typical interval remating. This creates an opportunity compete oocyte fertilization inside female’s tract. Drosophila melanogaster, characteristics seminal fluid content affect male success competition. On other hand, although...
Abstract Drosophila melanogaster females undergo a variety of post-mating changes that influence their activity, feeding behavior, metabolism, egg production and gene expression. These are induced either by mating itself or sperm seminal fluid proteins. In addition, studies have shown axenic females—those lacking microbiome—have altered fecundity compared to with microbiome, the microbiome female’s mate can reproductive success. However, extent which in transcript abundance affected state is...
The female reproductive tract is exposed directly to the male's ejaculate, making it a hotspot for mating-induced responses. In Drosophila melanogaster, changes in are essential optimize fertility. Many occur within minutes after mating, but such early timepoints absent from published RNA-seq studies. We measured transcript abundances using and microRNA-seq of tracts unmated mated females collected at 10-15 min post-mating. further investigated whether transcriptome influenced by inhibiting...
Abstract Background: Time-course multi-omics experiments have been highly informative for obtaining a comprehensive understanding of the dynamic relationships between molecules in biological process, especially if different profiles are obtained from same samples. A fundamental step analyzing time-course data involves selecting short list genes or gene regions (''sites'') that warrant further study. Two important criteria site selection magnitude change and temporal consistency. However,...
Atherosclerotic cardiovascular disease (CVD) is characterized by chronic inflammation of the artery wall triggered lipoprotein deposition. Maladaptive immune responses, primarily mediated macrophages (Mø), promote progression including extracellular matrix (ECM) remodeling. Emerging evidence suggests a relationship between cellular mechanics and metabolic programming, yet role ECM-induced mechanical stress on Mø immunometabolism remains unexplored. We hypothesized that induces...
<title>Abstract</title> <bold>Background:</bold> Time-course multi-omics experiments have been highly informative for obtaining a comprehensive understanding of the dynamic relationships between molecules in biological process, especially if different profiles are obtained from same samples. A fundamental step analyzing time-course data involves selecting short list genes or gene regions (''sites'') that warrant further study. Two important criteria site selection magnitude change and...
Time-course gene expression datasets provide insight into the dynamics of complex biological processes, such as immune response and organ development. It is interest to identify genes with similar temporal patterns because are often biologically related. However, this task challenging due high dimensionality these nonlinearity time dynamics. We propose an empirical Bayes approach estimating ordinary differential equation (ODE) models expression, from which we derive a similarity metric...
ABSTRACT Background Immune responses need to be initiated rapidly, and maintained as needed, prevent establishment growth of infections. At the same time, resources balanced with other physiological processes. On level transcription, studies have shown that this balancing act is reflected in tight control initiation kinetics shutdown dynamics specific immune genes. Results To investigate genome-wide expression trade-offs after infection at a high temporal resolution, we performed an RNA-seq...
Abstract Drosophila melanogaster females undergo a variety of post-mating changes that influence their activity, feeding behavior, metabolism, egg production and gene expression. These are induced either by mating itself or sperm seminal fluid proteins. In addition, studies have shown axenic females—those lacking microbiome—have altered fecundity compared to with microbiome, the microbiome female’s mate can reproductive success. However, extent which in transcript abundance affected state is...
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In many species, sperm can remain viable in the reproductive tract of a female well beyond typical interval to remating. This creates an opportunity for from different males compete oocyte fertilization inside female’s tract. Drosophila melanogaster , morphology and seminal fluid content affect male success competition. On other hand, although genome-wide association studies (GWAS) have demonstrated that genotype plays role competition outcome as well, biochemical, sensory physiological...
Abstract BackgroundImmune responses need to be initiated rapidly, and maintained as needed, prevent establishment growth of infections. At the same time, resources balanced with other physiological processes. On level transcription, studies have shown that this balancing act is reflected in tight control initiation kinetics shutdown dynamics specific immune genes. ResultsTo investigate expression trade-offs after infection genome-wide high temporal resolution, we performed an RNA-seq time...
Abstract Sex Peptide, a seminal fluid protein of D. melanogaster males, has been described as driving virgin-to-mated switch in females, through eliciting an array responses, including increased egg laying, activity and food intake decreased re-mating rate. While it is known that Peptide achieves this, at least part, by altering neuronal signaling the identity key molecular regulators act downstream not known. Here, we used high-resolution time series RNA-sequencing dataset female heads 10...