A5058619051- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Clusterin in disease pathology
- Medicinal Plants and Bioactive Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Heart Rate Variability and Autonomic Control
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Sleep and Wakefulness Research
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Sleep and related disorders
- Neuroendocrine regulation and behavior
- Rabbits: Nutrition, Reproduction, Health
- GDF15 and Related Biomarkers
- Caveolin-1 and cellular processes
- Amyotrophic Lateral Sclerosis Research
- Neuropeptides and Animal Physiology
- Agriculture Sustainability and Environmental Impact
University of Ulsan
2004-2024
Ulsan College
2005-2024
Seoul National University
2017-2024
Kyung Hee University Hospital at Gangdong
2024
Seoul Veterans Hospital
2024
University of Miyazaki
2015-2017
Shigakkan University
2015
Asan Medical Center
2010-2011
Leptin and insulin are important anorexigenic hormones acting on the hypothalamus. However, most obese humans animals have reduced hypothalamic responses to leptin insulin. Increased endoplasmic reticulum (ER) stress has been shown cause resistance in livers of animals. In present study, we investigated a role ER development central resistance. Intracerebroventricular (ICV) administration inducer thapsigargin (TG) increased food intake body weight. Furthermore, ICV or intra-hypothalamic TG...
A high-fat diet (HFD) induces inflammation in systemic organs including the hypothalamus, resulting obesity and diabetes. The vagus nerve connects visceral central nervous system, gastric-derived orexigenic peptide ghrelin transmits its starvation signals to hypothalamus via vagal afferent nerve. Here we investigated inflammatory response neurons mice following one day of HFD feeding. This treatment increased number macrophages/microglia nodose ganglion hypothalamus. Furthermore, one-day...
Glucagon-like peptide-1 amide (GLP-1) and gastric inhibitory polypeptide (GIP) are incretin hormones regulating energy metabolism. GLP-1 GIP combination is suggested as a promising therapeutic strategy for treatment of obesity diabetes. However, the neuronal mechanisms not yet investigated. In present study, we investigated role central in regulation body weight homeostasis. The effect with on food intake, weight, locomotor activity were determined following intracerebroventricular (ICV)...
OBJECTIVE The angiopoietin-like protein 4 (Angptl4)/fasting-induced adipose factor (Fiaf) is known as a regulator of peripheral lipid and glucose metabolism. In the present study, we investigated physiological role Angptl4 in central regulation body weight homeostasis. RESEARCH DESIGN AND METHODS Hypothalamic expression levels were measured using immunoblot assay during feeding manipulation or after administration leptin, insulin, nutrients. effects on food intake, weight, energy expenditure...
Ghrelin, a stomach-derived orexigenic peptide, transmits starvation signals to the hypothalamus via vagus afferent nerve. Peripheral administration of ghrelin does not induce food intake in high fat diet (HFD)-induced obese mice. We investigated whether this resistance was caused by dysfunction pathway. Administration (s.c.) did intake, suppression oxygen consumption, electrical activity vagal nerve, phosphorylation ERK2 and AMP-activated protein kinase alpha nodose ganglion, or Fos...
AMP-activated protein kinase (AMPK) acts as a cellular energy sensor, being activated during states of low charge. Hypothalamic AMPK activity is altered by hormonal and metabolic signals mediates the feeding response. To determine effect diabetes on hypothalamic activity, we assayed this in streptozotocin (STZ)-induced diabetic rats. Compared with control rats, STZ-induced rats had significant hyperphagia weight loss. phosphorylation α2-AMPK were higher acetyl-CoA carboxylase was lower than...
Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanisms underlying these phenomena, we established animal models of infection-associated anorexia by administrating bacterial viral products, lipopolysaccharide (LPS) human immunodeficiency virus-1 transactivator protein (Tat). In models, found that nuclear factor-kappaB (NF-kappaB), a pivotal transcription factor for inflammation-related proteins, was activated hypothalamus. parallel,...
Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipokine with insulin-sensitizing effects. However, the physiological role for vaspin in human metabolic regulation remains to be established.We studied 24-h profiles of circulating concentrations relation meal ingestion normal adults.Blood samples were drawn 39 times throughout period from 10 healthy male subjects provided meals on fixed schedule. On separate day, four fasted and then an unexpected clarify effect...
Abstract Small humanin-like peptide 2 (SHLP2) is a mitochondrial-derived implicated in several biological processes such as aging and oxidative stress. However, its functional role the regulation of energy homeostasis remains unclear, corresponding receptor not identified. Hereby, we demonstrate that both systemic intracerebroventricular (ICV) administrations SHLP2 protected male mice from high-fat diet (HFD)-induced obesity improved insulin sensitivity. In addition, activation...
Cherl NamKoong, Bohye Kim, Ji Hee Yu, Byung Soo Youn, Hanbin Evonne So Young Gil, Gil Myoung Kang, Chan Lee, Young-Bum Kyeong-Han Park, Min-Seon Kim & Obin Kwon. BMB Reports -0001;0:. https://doi.org/10.5483/BMBRep.2023-0117
Progranulin (PGRN) is a secreted glycoprotein with multiple biological functions, including modulation of wound healing and inflammation. Hypothalamic PGRN has been implicated in the development sexual dimorphism. In present study, potential role for hypothalamic regulation appetite body weight was investigated. adult rodents, highly expressed periventricular tanycytes neurons, which are known to contain glucose-sensing machinery. expression levels were decreased under low-energy conditions...
Parasympathetic nervous system (PNS) innervates with several peripheral organs such as liver, pancreas and regulates energy metabolism. However, the direct role of PNS on food intake has been poorly understood. In present study, we investigated parasympathetic in regulation feeding by chemogenetic methods. Adeno associated virus carrying DREADD (designer receptors exclusively activated designer drugs) infused into target brain region stereotaxic surgery. The stimulatory hM3Dq or inhibitory...
Circulating branched-chain amino acids (BCAAs) are elevated in obesity and diabetes, recent studies support a causal role for BCAAs insulin resistance defective glycemic control. The physiological mechanisms underlying BCAA regulation poorly understood. Here we show that signaling the mediobasal hypothalamus (MBH) of rats is mandatory lowering plasma BCAAs, most probably by inducing hepatic catabolism. Insulin receptor deletion only agouti-related protein (AgRP)–expressing neurons (AgRP...
Glucagon-like peptide-1 (GLP-1), whose agonists are widely prescribed, is a peptide proven effective in reducing obesity. Similarly, oxytocin (OXT) known to increase satiety and help reduce body weight. In the present study, we aimed examine metabolic effects of co-administration GLP-1 OXT diet-induced obesity (DIO) mice elucidate their functions interactions central nervous system. To this end, 40 DIO were subjected stereotaxic surgery for installation an osmotic minipump...