A5071455227- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Advanced Image and Video Retrieval Techniques
- Robotics and Sensor-Based Localization
- Metabolism, Diabetes, and Cancer
- Multimodal Machine Learning Applications
- Birth, Development, and Health
- Pancreatic function and diabetes
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Domain Adaptation and Few-Shot Learning
- Growth Hormone and Insulin-like Growth Factors
- Robot Manipulation and Learning
- Circadian rhythm and melatonin
- Thyroid Cancer Diagnosis and Treatment
- Dietary Effects on Health
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Clusterin in disease pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Advanced Vision and Imaging
- Lipid metabolism and disorders
Seoul National University
2021-2025
Seoul National University Hospital
2022-2025
New Generation University College
2021-2023
Yonsei University
2009-2021
Yonsei University College of Dentistry
2021
University of Ulsan
2016-2018
Ulsan College
2016-2018
Asan Medical Center
2016-2018
Harvard University
2018
McLean Hospital
2018
Obesity-associated metabolic alterations are closely linked to low-grade inflammation in peripheral organs, which macrophages play a central role. Using genetic labeling of myeloid lineage cells, we show that hypothalamic normally reside the perivascular area and circumventricular organ median eminence. Chronic consumption high-fat diet (HFD) induces expansion monocyte-derived macrophage pool arcuate nucleus (ARC), is significantly attributed enhanced proliferation macrophages. Notably,...
We propose a novel type of map for visual navigation, renderable neural radiance (RNR-Map), which is designed to contain the overall information 3D environment. The RNR-Map has grid form and consists latent codes at each pixel. These are embedded from image observations, can be converted field enables rendering given camera pose. recorded implicitly about environment, makes visually descriptive. This in useful guideline localization navigation. develop navigation frameworks that effectively...
Statins (HMGCR/HMG-CoA reductase [3-hydroxy-3-methylglutaryl-CoA reductase] inhibitors) are widely used to lower blood cholesterol levels but have been shown increase the risk of type 2 diabetes mellitus. However, molecular mechanism underlying diabetogenic effects remains be elucidated. Here we show that statins significantly expression key gluconeogenic enzymes (such as G6PC [glucose-6-phosphatase] and PCK1 (phosphoenolpyruvate carboxykinase 1 [soluble]) in vitro vivo promote hepatic...
We present a novel graph-structured memory for visual navigation, called graph (VGM), which consists of unsupervised image representations obtained from navigation history. The proposed VGM is constructed incrementally based on the similarities among observed images, and these are learned an unlabeled dataset. also propose framework that can utilize to tackle problems. By incorporating convolutional network attention mechanism, agent refers navigate environment while simultaneously building...
Abstract Nicotinamide adenine dinucleotide (NAD + ) is an essential cofactor of critical enzymes including protein deacetylase sirtuins/SIRTs and its levels in mammalian cells rely on the nicotinamide phosphoribosyltransferase (NAMPT)-mediated salvage pathway. Intracellular NAMPT (iNAMPT) secreted found blood as extracellular (eNAMPT). In liver, iNAMPT−NAD axis oscillates a circadian manner regulates cellular clockwork. Here we show that hypothalamic NAD distinct fluctuation with nocturnal...
IntroductionMulticiliated cells (MCCs) have been identified in the proximal tubules of patients with kidney disease; however, their clinical significance is unknown. We aimed to investigate whether MCCs are associated outcomes glomerular diseases.MethodsBetween August 2012 and April 2021, 134 (including 126 disease 8 controls) who were hospitalized at Seoul National University Boramae Medical Center Hospital included this study. The ratio total tubular was calculated using...
It was previously reported in Korea that there were 1.4 case per million year of acromegaly. This low comparison with the extrapolated values Western European countries. We expected incidence acromegaly would be much higher now because recently improved medical facilities, diagnostic tools and coverage insurance to all population South Korea.The purpose this nationwide survey examine prevalence patients acromegaly, mode treatment outcome surgical recent 5 years.We requested collected records...
Incretin hormone-based therapy in type 2 diabetes has been widely used, and dipepdityl peptidase-4 (DPP-4) inhibitors, which prevent incretin degradation, have become popular oral hypoglycemic agents. The efficacy of DPP-4 inhibitors varies from individuals, factors determining responses to not fully established. We aimed investigate whether genetic variations glucagon-like peptide (GLP-1) receptor are associated with patients diabetes. Genetic rs3765467 GLP-1 were explored 246 who received...
Abstract Neurodegenerative diseases are explained by progressive defects of cognitive function and memory. These cognition memory dysfunction can be induced the loss brain-derived neurotrophic factors (BDNF) signaling. Paeonia lactiflora is a traditionally used medicinal herb in Asian countries some beneficial effects have been reported, including anti-oxidative, anti-inflammatory, anti-cancer activity, potential neuroprotective recently. In this study, we found that suffruticosol A major...
Abstract Background This study compared the progression of experimental peri‐implantitis between alveolar ridge preservation (ARP) and spontaneous healing (SH) sites in infected (IT) noninfected tooth (NIT). Methods Bilateral mandibular third or fourth premolars six beagle dogs were randomly assigned to IT NIT groups. Before extraction, chronic dehiscence defects created at mesial root mid‐buccal area group. Four weeks later, roots extracted all groups.ARP procedure was conducted on one side...
We evaluated the effects of two dipeptidyl peptidase-4 (DPP-4) inhibitors, sitagliptin and vildagliptin, on metabolic parameters in patients with type 2 diabetes mellitus.A total 170 treated or vildagliptin for more than 24 weeks were selected. The separated into groups, (100 mg once daily, n=93) (50 twice n=77). compared effect each DPP-4 inhibitor parameters, including fasting plasma glucose (FPG), postprandial (PPG), glycated hemoglobin (HbA1c), albumin (GA) levels, lipid at baseline...
Cherl NamKoong, Bohye Kim, Ji Hee Yu, Byung Soo Youn, Hanbin Evonne So Young Gil, Gil Myoung Kang, Chan Lee, Young-Bum Kyeong-Han Park, Min-Seon Kim & Obin Kwon. BMB Reports -0001;0:. https://doi.org/10.5483/BMBRep.2023-0117
Heme oxygenase (HO)-1 is a key enzyme in cytoprotective mechanisms against oxidative stress the cardiovascular-renal system. The T(-413)A single nucleotide polymorphism (SNP) and (GT)n microsatellite HO-1 gene promoter modulate transcriptional activity these polymorphisms are associated with various human diseases. We investigated association between nephropathy type 2 diabetes. sequenced SNP repeat segments of 536 patients alleles were divided into groups: short (S, ≤25 GT repeats) long (L,...
N6-Methyladenosine (m6A) RNA modification plays a critical role in the posttranscriptional regulation of gene expression. Alterations cellular m6A levels and m6A-related genes have been reported many cancers, but whether they play oncogenic or tumor-suppressive roles is inconsistent across cancer types. We investigated common features alterations during carcinogenesis by analyzing transcriptome data 11 solid tumors from The Cancer Genome Atlas database our in-house gastric cohort. calculated...
The prevalence of obesity in children and adolescents is increasing worldwide, which concern because can lead to various complications such as metabolic syndrome (MS). Waist circumference (WC) waist-height ratio (WHtR) are useful indicators abdominal MS. In this study, we investigate trends the MS using two different references.Data from Korea National Health Nutrition Examination Survey (2007 2020) were used. total, 21,652 participants aged 2 18 years 9,592 10 analyzed for MS, respectively....