A5006816656- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Mental Health Research Topics
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Eating Disorders and Behaviors
- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Resilience and Mental Health
- Mental Health Treatment and Access
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Circadian rhythm and melatonin
- Psychology of Moral and Emotional Judgment
- Cancer survivorship and care
- Transcranial Magnetic Stimulation Studies
- Family Support in Illness
- Evolutionary Psychology and Human Behavior
- Epigenetics and DNA Methylation
- Personality Disorders and Psychopathology
Yonsei University
2015-2024
Yonsei University Health System
2024
University of California, San Francisco
2020-2021
CHA Bundang Medical Center
2021
CHA University
2021
Severance Hospital
2013-2020
King's College London
2019
Institute of Behavioral Sciences
2016
Neuroscience Institute
2011
National Health Insurance Service
2008-2011
DNA methylation patterns at specific cytosine-phosphate-guanine (CpG) sites predictably change with age and can be used to derive "epigenetic age", an indicator of biological age, as opposed merely chronological age. A relatively new estimator, called "DNAm GrimAge", is notable for its superior predictive ability in older populations regarding numerous age-related metrics like time-to-death, time-to-coronary heart disease, time-to-cancer. PTSD associated premature mortality frequently has...
Article AbstractObjective: The present study investigated possible therapeutic effects and safety of sequentially combined low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex supplementary motor area in patients with treatment-resistant obsessive-compulsive disorder. Method: Between February 2007 January 2008, we carried out a rater-blinded, sham-controlled design which 20 disorder, confirmed by psychiatrist after use Structured...
Objective: Decline in psychosocial functioning seems to be a core feature schizophrenia across various phases of the disorder. Little is known about relationship between and protective factors or psychopathologies individuals prodrome phase psychosis. We aimed investigate whether impaired putative prodromal schizophrenia, and, if so, identify associated with compromised functioning. Method: Sixty participants at ultra-high risk (UHR) for psychosis 47 healthy controls were recruited. All...
Objective Although the relationship between obsessive compulsive disorder (OCD) and impulsivity has long been debated, not systematically examined in clinical samples of OCD. Meanwhile, recent findings suggest that is multi-dimensional construct can be through several constructs. Therefore, this study aimed to evaluate multiple facets Method The recruitment includes 80 OCD 76 healthy control participants. Participants completed a test battery comprising three behavioral tasks stop signal...
Objective Brain‐derived neurotrophic factor ( BDNF ) plays a crucial role in modulating resilience and vulnerability to stress. The aim of this study was investigate whether epigenetic regulation the gene is biomarker post‐traumatic stress disorder PTSD development among veterans exposed combat Vietnam War. Methods Using Clinician‐Administered Scale, were grouped into those with n = 126) without 122) . DNA methylation levels at four CpG sites within promoter I region quantified peripheral...
Article Abstract Objective: The aim of this randomized, sham-controlled study was to investigate the therapeutic effects underlying neurobiological changes after 2-week repetitive transcranial magnetic stimulation (rTMS) treatment using functional connectivity resonance imaging in patients with major depression. Methods: Twenty-four depressive disorder diagnosed DSM-IV-TR criteria were randomly assigned active rTMS (n = 13) or sham 11) groups from January 2009 June 2011. given for 2 weeks at...
Abstract Mental adjustment and coping affect the physical outcome survival as well quality of life in cancer patients. The Mini‐Mental Adjustment to Cancer (Mini‐MAC) scale is a new refined, economical reliable self‐rating instrument measuring cognitive behavioral responses cancer. aim this study was evaluate psychometric properties Mini‐MAC Korean A total 208 patients recruited from Yonsei Center were assessed with Hospital Anxiety Depression Scale (HADS). Principal component analysis...
Circadian preference has been considered related with impulsivity. The purpose of the present study was to evaluate relationship between circadian typology and impulsivity measured by Barratt Impulsivity Scale (BIS), sensation-seeking Sensation Seeking - Form V (SSS-V) response inhibition elicited GO/NO-GO paradigm. A total 503 Korean healthy college students (288 males 215 females) completed Composite Morningness (CSM) for BIS SSS-V risk taking, respectively. subset 142 subjects...
Early life stress (ELS) leads to increased susceptibility serious psychiatric problems such as alcohol dependence, but the mechanisms through which ELS affects dependence are unclear. We investigated mediating role of multi-dimensional impulsivity in associations between and dependence. 330 male patients with (mean age = 48.39) completed self-rating scales several self-report measures well balloon analogue risk task (BART). After classifying different dimensions using factor analysis,...
Negative symptoms are recognized as a fundamental feature of schizophrenia throughout the disease course. Epigenetic alterations in oxytocin receptor gene (OXTR) may be key mechanism involved social-emotional disturbances schizophrenia. Here, we investigated OXTR methylation and its association with clinical brain network connectivity phenotypes negative symptoms, particularly anhedonia-asociality, individuals recent-onset (ROS) at ultrahigh risk (UHR) for psychosis. Sixty-four ROS (39...
Current pharmacological treatments of post-traumatic stress disorder (PTSD) have limited efficacy. Although the diagnosis is based on psychopathological criteria, it frequently accompanied by somatic comorbidities and perhaps "accelerated biological aging," suggesting widespread physical concomitants. Such physiological may affect core PTSD symptoms but are rarely focus therapeutic trials.To elucidate potential involvement metabolism, inflammation, mitochondrial function in PTSD, we...