A5091734103- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Tryptophan and brain disorders
- Mental Health and Psychiatry
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Neuroscience and Music Perception
- Resilience and Mental Health
- Psychosocial Factors Impacting Youth
- MRI in cancer diagnosis
- Mindfulness and Compassion Interventions
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Media Influence and Politics
CHA Bundang Medical Center
2018-2025
CHA University
2018-2025
Samsung Medical Center
2023
Kyungpook National University
2023
National Bureau of Economic Research
2023
City University of Hong Kong
2023
California University of Pennsylvania
2023
University of Pennsylvania
2023
Konkuk University
2015-2022
Dankook University
2022
Abstract Although the role of cerebellum in schizophrenia has gained attention, its contribution to cognitive impairment remains unclear. We aimed investigate volumetric alterations cerebro-cerebellar gray matter (GM) patients with recent-onset (ROS) and chronic (CS) compared healthy controls (HCs). Seventy-two ROS, 43 CS, 127 HC participants were recruited, high-resolution T1-weighted structural magnetic resonance images brain acquired. cerebellar GM volumes among groups using voxel-based...
Due to their inert property, gold nanoparticles (AuNPs) have drawn considerable attention; biological application has recently expanded include nanomedicine and neuroscience. However, the effect of AuNPs on bioelectrical properties a single neuron remains unknown. Here we present under physiological pathological conditions in vitro. were intracellularly applied hippocampal CA1 neurons from mouse brain. The electrophysiological property treated with 5- or 40-nm was assessed using whole-cell...
Objective: Impairments in neurocognitive function are considered as core features of schizophrenia. Individuals at ultra-high risk (UHR) for psychosis, the ‘putative’ prodrome schizophrenia, generally show levels impairments intermediate between schizophrenia patients and healthy controls. We investigated performance individuals UHR comparing them with first-episode (FES) controls (HC), explored predictivity baseline group transition to overt psychosis. Method: psychosis ( n = 60), FES 39),...
Although the majority of patients with schizophrenia are not actually violent, an increased tendency toward violent behaviors is known to be associated schizophrenia. There several factors consider when identifying subgroup who may commit or aggressive acts. Comorbidity substance abuse most important clinical indicator and crime rates in Genetic studies have proposed that polymorphisms promoter region serotonin transporter gene catechol-O-methyltransferase related aggression. Neuroimaging...
Abstract Schizophrenia is a complex brain disorder of unknown etiology. Based on the notion “cognitive dysmetria,” we aimed to investigate aberrations in structural white matter (WM) connectivity that links cerebellum cognitive dysfunction patients with schizophrenia. A total 112 participants (65 schizophrenia and 47 healthy controls [HCs]) were enrolled underwent diffusion tensor imaging. Between-group voxel-wise comparisons cerebellar WM regions (superior/middle [MCP]/inferior peduncle...
Abstract There is a growing need to develop novel strategies for the diagnosis of schizophrenia using neuroimaging biomarkers. We investigated robustness diagnostic model radiomic features from T1-weighted and diffusion tensor images corpus callosum (CC). A total 165 participants [86 79 healthy controls (HCs)] were allocated training ( N = 115) test 50) sets. Radiomic CC subregions extracted T1-weighted, apparent coefficient (ADC), fractional anisotropy (FA) 1605). Following feature...
Social cognition, the perception and processing of social information, is adversely affected in multiple psychiatric, neurological, neurodevelopmental disorders, these impairments negatively impact quality life for individuals across globe. Despite clear importance efforts to advance research via harmonization data cultures diagnoses has been stymied by lack uniformly used suitable assessments. To address this issue, current study conducted an expert survey consensus process identify...
Negative symptoms are recognized as a fundamental feature of schizophrenia throughout the disease course. Epigenetic alterations in oxytocin receptor gene (OXTR) may be key mechanism involved social-emotional disturbances schizophrenia. Here, we investigated OXTR methylation and its association with clinical brain network connectivity phenotypes negative symptoms, particularly anhedonia-asociality, individuals recent-onset (ROS) at ultrahigh risk (UHR) for psychosis. Sixty-four ROS (39...
Brain aging is an inevitable process characterized by structural and functional changes a major risk factor for neurodegenerative diseases. Most brain studies are focused on neurons less astrocytes which the most abundant cells in known to be charge of various functions including maintenance physical formation, ion homeostasis, secretion extracellular matrix proteins. Altered mitochondrial dynamics, defective mitophagy or damages causative factors dysfunction, linked age-related disorders....
Abstract Brain inflammation is one of hypotheses explaining complex pathomechanisms depression. Angiotensin II (ANGII), which associated with hypertension, also induces brain inflammation. However, there no animal study showing the direct relationship between ANGII and To address this issue, ANGII-containing osmotic pumps were implanted into adult male C57BL/6 mice subcutaneously for subacute (7 days) chronic (at least 21 periods behavioral molecular analyses conducted. Chronic infusion...
Abstract Background and Hypothesis Schizophrenia involves microstructural changes in white matter (WM) tracts. Oxidative stress is a key factor causing WM damage by hindering oligodendrocyte development myelin maturation. Uric acid (UA), an endogenous antioxidant, may protect against oxidative stress. We investigated the effect of UA on connectivity antipsychotic-naive or -free patients with early- chronic-stage schizophrenia. Study Design A total 192 schizophrenia (122 recent-onset [ROS] 70...
Abstract At present, therapeutic options available for treating schizophrenia are limited to monoamine-based antipsychotic drugs. Recent genome wide association study (GWAS) indicated a close relationship between immune system and schizophrenia. To leverage the GWAS finding strategy, we conducted mechanism effect on application of human umbilical cord-derived mesenchymal stem cells (hUC-MSC) with potent immune-modulatory in an animal model useful Schizophrenia-relevant behaviors were induced...
Aim To improve strategies for the early identification of individuals at a heightened risk development psychosis, we investigated relationships and interactions between 3 psychosis‐proneness dimensions schizophrenia spectrum psychosis: schizotypy, basic symptoms ultra‐high (UHR) criteria. Methods Seventy‐seven UHR 79 healthy controls were assessed schizotypy using self‐report questionnaires baseline. participants monthly conversion to psychosis over mean period 25.8 months. Results Sixteen...
Impaired verbal communication is a prominent feature in patients with schizophrenia. Verbal difficulties adversely affect psychosocial outcomes and worsen schizophrenia's clinical manifestation. In the present study, we aimed to investigate associations among gray matter (GM) volumes language processing areas (LPAs), ability, positive symptoms first-episode (FEPs) schizophrenia spectrum psychosis.We enrolled 94 FEPs 52 healthy controls (HCs) subjected them structural magnetic resonance...