A5070739739- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Sleep and related disorders
- Child and Adolescent Psychosocial and Emotional Development
- Attention Deficit Hyperactivity Disorder
- Circadian rhythm and melatonin
- Personality Disorders and Psychopathology
- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- Obstructive Sleep Apnea Research
- Electroconvulsive Therapy Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Autism Spectrum Disorder Research
- Mental Health and Psychiatry
- Stress Responses and Cortisol
- Genetic Associations and Epidemiology
- Nuclear Physics and Applications
- Cardiac electrophysiology and arrhythmias
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
Eulji University
2016-2025
Eulji University Hospital
2022-2025
Eulji General Hospital
2014-2024
Gwangmyeong Mental Health Welfare Center
2019
Sogang University
2015-2017
Heidelberg University
2017
International University of Japan
2017
Hanyang University
2017
University of Iowa
2014
Seoul National University
2004-2009
Article AbstractObjective: Inadequate response to clozapine poses a substantial problem in the pharmacotherapy of refractory schizophrenia. This randomized, double-blind, placebo-controlled study evaluated efficacy and safety aripiprazole augmentation clozapine-treated patients with Method: Patients DSM-IV schizophrenia who had history treatment failure or partial long-term were recruited. A total 62 either baseline Brief Psychiatric Rating Scale (BPRS) score at least 35 more than 2 Schedule...
To identify the distributed brain regions used for appreciating grammatical, semantic and thematic aspects of a story, regional cerebral blood flow was measured with positron emission tomography in nine normal volunteers during reading Aesop's fables. In four conditions, subjects had to monitor fables font changes, grammatical errors, feature associated fable character, moral fable. Both right left prefrontal cortices were consistently, but selectively, activated across semantic, conditions....
Although a broad range of circadian rhythm variations have been reported, analyses chronotypes in bipolar I disorder (BDI) and schizophrenia are rare. The present study aimed to investigate specific chronotype patterns BDI compared with healthy subjects.All patients were clinically stable recruited from the outpatient clinics Seoul National University Hospital. They diagnosed according DSM-IV criteria. 'Morningness/eveningness', correlated phase, was evaluated using Composite Scale...
Objective Currently, there are a few biological markers to aid in the diagnosis and treatment of depression. However, it is not sufficient for diagnosis. We attempted identify differentially expressed proteins during depressive moods as putative diagnostic biomarkers by using quantitative proteomic analysis serum. Methods Blood samples were collected twice from five patients with major disorder (MDD) at status before remission treatment. Samples individually analyzed liquid...
Morningness/eveningness (M/E) is a stable characteristic of individuals. Circadian rhythms are altered in episodes mood disorder. Mood disorder patients were more evening-type than normal population. In this study, we compared the characteristics M/E among 257 with bipolar I (BPD1), II (BPD2) and major depressive disorder, recurrent (MDDR).M/E was evaluated using Korean version composite scale morningness (CS). Factor analysis done to extract specific elements circadian rhythm (morning...
Article Abstract Objective: High rates of childhood trauma and adult suicidality have been reported in patients who schizophrenia. This study sought to explore mediators between adulthood help determine therapeutic approaches. Methods: included 314 with early psychosis were participants the Korean Early Psychosis Cohort Study, which was a prospective naturalistic observational cohort started December 2014. DSM-5 criteria used assign diagnosis schizophrenia spectrum other psychotic disorders....
In boron neutron capture therapy (BNCT), patient dose is contingent upon concentration and irradiation. This study details the creation implementation of a real-time beam-monitoring system using Eu:LiCaAlF6 (LiCAF) scintillation detector. precisely regulates irradiation according to treatment plan. A two-step calibration process was employed for enhanced reliability. The initial used an Americium–Beryllium (AmBe) source isolate signals from mix gamma signals. second involved polymethyl...
Abstract Early growth response ( EGR ) genes play critical roles in signal transduction the brain, which is involved neuronal activation, brain development, and synaptic plasticity. genes, including EGR2 , EGR3 EGR4 showed significant association with schizophrenia Japanese schizophrenic pedigrees. In particular, resides at chromosomal location 8p21.3, was suggested to be a potential susceptibility gene based on study of cases. However, this requires further replication an independent sample...
Objective We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship antipsychotic medications. Methods This multicenter, cross-sectional, observational included patients diagnosed schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 aged 18 65 years prescribed any medication between August 2011 2013. MetS was using modified Adult Treatment Panel III National Cholesterol...
Abstract Boron neutron capture therapy (BNCT) has been attracting interest as a new radiation modality for cancer because it can selectively destroy cells while maintaining the healthy state of surrounding normal cells. Many experimental trials have demonstrated significant BNCT treatment efficacy using beams from research reactors. However, nuclear reactor technology cannot be scaled to sites in hospitals delivering patient treatment. Therefore, compact accelerator-based sources that could...
In the present study, various outcomes over 3-year period in patients with early stage psychosis including remission, recovery, relapse and medication adherence were investigated. Predictor for full recovery at year 3 was also examined. Three-year follow-up data 534 schizophrenia spectrum disorders (SSD) psychotic disorder not otherwise specified (PNOS) examined overall outcome trajectories. The of completers (n = 157) used to identify predictors using logistic regression. rates symptomatic...
Article Abstract Objective: We investigated the effect long-term clozapine add-on therapy has on rehospitalization rate and mood polarity patterns in patients with bipolar disorders. Method: Clinical data from medical records of 51 disorder (DSM-IV) treated for more than 6 months at Refractory Bipolar Disorders Clinic Seoul National University Hospital were retrospectively analyzed. Patients had been registered 1995 to 2004. Rehospitalization rates compared before after add-on. The clinical...
The present study details the rationale and methodology of Korean Early Psychosis Cohort Study (KEPS), which is a clinical cohort investigation first episode psychosis patients from population. KEPS prospective naturalistic observational that follows participants for at least 2 years. This includes between 18 45 years age who fulfill criteria one schizophrenia spectrum other psychotic disorders according to diagnostic DSM-5. defined as received antipsychotic treatment fewer than 4...
We investigated possible association between depressive disorders and BDNF Val66Met 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene serotonin transporter (SLC6A4) are promising candidate genes for disorders. It has been suggested that promotes the survival differentiation of serotonergic neurons transmission exerts powerful control over expression.Final analyses were performed on 186 patients with 1032 controls. polymorphism 5-HTTLPR genotyped allele genotypic associations diagnosis...
For the proper treatment of first-episode psychosis, assessment response, remission, relapse, and recovery is important. Therefore, present study aimed to develop operational definitions clinical outcomes in psychosis.