A5101404824- Mass Spectrometry Techniques and Applications
- Tryptophan and brain disorders
- Perovskite Materials and Applications
- Conducting polymers and applications
- Organic Electronics and Photovoltaics
- Bipolar Disorder and Treatment
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Ion-surface interactions and analysis
- Computational Drug Discovery Methods
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Cell death mechanisms and regulation
- Neurogenesis and neuroplasticity mechanisms
- Glycosylation and Glycoproteins Research
- Neuroscience and Neuropharmacology Research
- melanin and skin pigmentation
- Bioinformatics and Genomic Networks
- Diverse Approaches in Healthcare and Education Studies
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Silicone and Siloxane Chemistry
- Stroke Rehabilitation and Recovery
Seoul National University
2019-2025
Dongguk University
2020-2024
Korea Basic Science Institute
2024
Yonsei University
2015-2023
Ewha Womans University
2023
University of Minnesota
2020-2023
Korea Advanced Institute of Science and Technology
2023
Kyungpook National University
2022
Hallym University
2021
Chungnam National University
2013-2020
This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain physical functions in high-risk older adults. In randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through clinical interview conducted by dementia specialist. Cognitive assessments were performed neuropsychologists according standardized methods, including Mini-Mental State...
Abstract Background The persistence of adult hippocampal neurogenesis (AHN) is sharply decreased in Alzheimer’s disease (AD). neuropathologies AD include the presence amyloid-β deposition plaques, tau hyperphosphorylation neurofibrillary tangles, and cholinergic system degeneration. focused ultrasound (FUS)-mediated blood-brain barrier opening modulates hyperphosphorylation, accumulation proteins, increases AHN. However, it remains unclear whether FUS can modulate AHN cholinergic-deficient...
In emerging perovskite transistors, interfacial engineering is pivotal for modulating the effective charge carrier transport; however, gate dielectric layer and its interface remain unexplored owing to limited chemical stability of perovskites. Here, we propose an functionalization with a conjugated polymer allow use high capacitance electrolyte in top-gate transistors. This multifunctional approach, exploiting orthogonal solution-processed polymers, enables blocking diffusion during...
The color of mammalian skin is determined by many factors, for which visible ones are the degree and distribution melanin pigmentation. Because tyrosinase, (polyphenol oxidase) key enzyme biosynthesis, use various tyrosinase inhibitors a common practice whitening purpose in cosmetics. In present study, inhibition 4,4′-dihydroxybiphenyl (44′-BP) was investigated. addition to inhibiting activity, biosynthesis assessed B16F10 melanoma cells (B16 cells). results showed that 44′-BP exhibits...
Despite advances in clinical proteomics, translating protein biomarker discoveries into use remains challenging due to the technical complexity of validation process. Targeted MS-based proteomics approaches such as parallel reaction monitoring (PRM) offer sensitive and specific assays for translation. In this study, we developed a multiplex PRM assay using Stellar mass spectrometry platform quantify 57 plasma proteins, including 21 FDA-approved proteins. Loading curves (11-points) were...
Deep brain stimulation has recently been considered a potential therapy in improving memory function. It shown that change of neurotransmitters an effect on However, much about the exact underlying neural mechanism is not yet completely understood. We therefore examined changes neurotransmitter systems and spatial caused by nucleus basalis magnocellularis rat model dementia. divided rats into four groups: Normal, Lesion, Implantation, Stimulation. used 192 IgG-saporin for degeneration basal...
Inulae Flos, the flower of Inula britannica L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated gastroprotective effects Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol rats explored its potential mechanisms measuring antioxidant enzyme activity, mucus secretion, prostaglandin E2 (PGE2) levels. Pretreatment with IFE at doses 100 300 mg/kg significantly inhibited HCl/ethanol-treated rats. increased...
Alzheimer disease (AD) is a leading cause of dementia that has gained prominence in our aging society. Yet, the complexity diagnosing AD and measuring its invasiveness poses an obstacle. To this end, blood-based biomarkers could mitigate inconveniences impede accurate diagnosis. We developed models to diagnose measure severity neurocognitive impairment using blood protein biomarkers. Multiple reaction monitoring-mass spectrometry, highly selective sensitive approach for quantifying targeted...
Surface-enhanced Raman scattering (SERS) is a promising, sensitive, and label-free molecule detection scheme. However, uniformity reproducibility of signal enhancement have remained elusive, making quantitative evaluation difficult. In this work, we propose simple fabrication approach to SERS sensors that satisfies all the sought-after characteristics: gold hole-sphere nanogap substrate uniform, reproducible, large, cost-effective. Here, achieve sensing 4.2% averaged over 4 points throughout...
Human epidermal growth factor receptor 2 (HER2) is often overexpressed in breast cancer and correlates with a worse prognosis. Thus, the accurate detection of HER2 crucial for providing appropriate measures patients. However, current techniques used to detect status, immunohistochemistry fluorescence situ hybridization (FISH), have limitations. Specifically, FISH, which mandatory arbitrating 2+ cases, time-consuming costly. To address this shortcoming, we established multiple reaction...
Glycoproteins have many important biological functions. In particular, aberrant glycosylation has been observed in various cancers, such as liver cancer. A well-known glycoprotein biomarker is α-fetoprotein (AFP), a surveillance for hepatocellular carcinoma (HCC) that contains site at asparagine 251. The low diagnostic sensitivity of AFP led researchers to focus on AFP-L3, which the same sequence conventional but fucosylated glycan. AFP-L3 high affinity Lens culinaris agglutinin (LCA)...
Advancing the performance of perovskite photovoltaics (PPVs) complementarily necessitates utilization charge transport layers. The development functionalized hole materials (HTMs) through precise tuning conjugated core structures and side groups is crucial for realizing efficient extraction photogenerated carriers in PPVs. Here, we prepared a series polymeric HTMs with various amounts lengths oligo(ethylene glycol) (OEG) to identify effect latter on HTM Subsequent analysis revealed that...
Random polythiophene polymers are characterized by the arbitrary sequences of monomeric units along polymer backbones. These untailored orientations generally result in twisting thiophene rings out conjugation planarity addition to steric repulsions experienced among substituted alkyl chains. tendencies have limited close packing, which has been detrimental charge transport these moieties. To ameliorate classes polymers, we make use simple Stille coupling polymerization synthesize highly...
Eight representative explosives (ammonium perchlorate (AP), ammonium nitrate (AN), trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), cyclonite (RDX), cyclotetramethylenetetranitramine (HMX), pentaerythritol tetranitrate (PETN), and hexanitrostilbene (HNS)) were comprehensively analyzed with an ion trap mass spectrometer in negative mode using direct infusion electrospray ionization. MS/MS experiments performed to generate fragment ions from the major parent of each explosive. Explosives salt...
Family caregivers of hospice patients experience burden care, various unmet needs, and emotional pain, especially in cultures where social responsibilities are imposed on families with terminally ill patients. This study investigated needs caregiving patients’ family South Korea who care for as they dying. A descriptive correlation design queried 101 hospitalized 4 urban palliative institutions. Data gathered between September 2015 March 2016 were analyzed using statistics correlations....
Because major depressive disorder (MDD) and bipolar (BD) manifest with similar symptoms, misdiagnosis is a persistent issue, necessitating their differentiation through objective methods. This study was aimed to differentiate between these disorders using targeted proteomic approach. Multiple reaction monitoring-mass spectrometry (MRM-MS) analysis performed quantify protein targets regarding the two in plasma samples of 270 individuals (90 MDD, 90 BD, healthy controls (HCs)). In training set...