A5076776987- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antimicrobial agents and applications
- Pharmacological Effects of Natural Compounds
- Redox biology and oxidative stress
- Trace Elements in Health
- Medicinal plant effects and applications
- Nitric Oxide and Endothelin Effects
- Toxin Mechanisms and Immunotoxins
- Atherosclerosis and Cardiovascular Diseases
- Retinoids in leukemia and cellular processes
- Medicinal Plants and Bioactive Compounds
- Cell death mechanisms and regulation
- Phytochemistry and Biological Activities
- Protein Tyrosine Phosphatases
- Birth, Development, and Health
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Herbal Medicine Research Studies
Korea Institute of Toxicology
2013-2024
Seoul National University Bundang Hospital
2020-2024
Asan Medical Center
2020
Korea University of Science and Technology
2018
Pusan National University
2000-2013
Korea Basic Science Institute
2012
Chungnam National University
2008-2010
National Cancer Institute
2008
National Institutes of Health
2008
Center for Cancer Research
2008
The combined effects of aging and regular physical exercise was investigated on the production reactive oxygen species (ROS), lipid peroxidation, glutathione status, activity nuclear factor-kappaB (NF-kappaB) in rat liver. A group 24 male F344 rats divided into following categories: adult control (18 months), exercised aged (28 months) months). ROS formation increased as a function age training decreased rate two groups. Significant positive correlation found between peroxidation (LIPOX)....
AbstractPeroxynitrite (ONOO-) is a reactive oxidant formed from superoxide (•O2-) and nitric oxide (•NO), that can oxidize several cellular components, including essential protein, non-protein thiols, DNA, low-density lipoproteins (LDL), membrane phospholipids. ONOO- has contributed to the pathogenesis of diseases such as stroke, heart disease, Alzheimer's atherosclerosis. Because lack endogenous enzymes thwart activation, developing specific scavenger remarkably important. In this study,...
To investigate the status of soluble adhesion molecules (sAMs) during aging, present study determined protein levels several major sAMs in serum samples obtained from rats at different ages. These include E-selectin, P-selectin, vascular cell molecule 1 (VCAM-1), and intercellular (ICAM-1). Fischer 344 rats, ages 6, 12, 18, 24 months, fed ad libitum (AL) calorie restricted (CR) diets were used this study. Analysis by Western blotting showed that all studied increased aging AL but effectively...
Betaine is an important human nutrient obtained from various foods. In the present study, we assessed anti-inflammatory effect of betaine on nuclear factor-kappaB (NF-kappaB) during aging. Sprague-Dawley (SD) rats, ages 7 and 21 months, were used in this study. The older rats fed betaine. To elucidate oxidative stress-induced NF-kappaB its signaling pathway at molecular levels, YPEN-1 cells used. Results showed that suppressed related gene expressions cyclooxygenase-2 (COX-2), inducible...
4‐Hydroxyhexenal (HHE) is known to affect redox balance during aging, included are vascular dysfunctions. To better understand abnormality through the molecular alterations resulting from HHE accumulation in aging processes, we set out determine whether up‐regulation of mitogen‐activated protein kinase (MAPK) by mediated nuclear factor kappa B (NF‐κB) activation endothelial cells. induced NF‐κB inhibitor κB (IκB) phosphorylation via IκB (IKK)/NF‐κB inducing (NIK) pathway. increased activity...
Summary Nuclear factor‐κB (NF‐κB), a redox‐sensitive transcription factor, plays an important role in the aging process. Thus, developing and identifying specific components that modulate NF‐κB without adverse side‐effects would be of major importance. Hesperetin, flavanone abundant citrus fruits, has variety pharmacological properties being antioxidant, cholesterol‐lowering, anti‐inflammatory. In this study, we investigated how hesperetin fed to 6‐ 24‐month‐old rats modulates their kidneys....
To investigate effects of aging on adhesion molecules (AMs), the present study assessed expressions aortic P-selectin and vascular molecule-1 (VCAM-1) in young (6-month-old) old (24-month-old) Fischer 344 rats fed ad libitum (AL) or calorie-restricted diets. Results showed increased levels VCAM-1 AL rats, causing excessive leukocyte infiltration as indicated by enhanced myeloperoxidase level. These elevations were parallel to oxidative stress including lipid peroxides during aging. Then...
Depletion of glutathione levels and perturbations in redox status are considered to play a crucial role aging chronic inflammatory processes through the activation sensitive transcription factors, including nuclear factor-κB (NF-κB). In current study, we assessed regulatory action dietary betaine suppression NF-κB by comparing kidney tissue from old, betaine-supplemented rats or non-betaine-supplemented (age 21 months) 7 month-old rats. addition, cultured HEK 293T cells were utilized for...
Lysophosphatidylcholine (LPC) is a lysolipid, acting as potent cellular mediator of various biological processes. The purpose this study was to define the role LPC possible causative factor disrupted redox balance in aged aorta from rats. In study, we found elevated serum levels 24-month-old rats that were correlated with age-related increase cytosolic phospholipase A2 (PLA2) activity. We also aortas old showed increased 5-lipoxygenase (5-LO) With LPC-treated endothelial cells (YPEN-1...