A5043231970- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- ATP Synthase and ATPases Research
- Reproductive System and Pregnancy
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Congenital heart defects research
- Endometriosis Research and Treatment
- Sirtuins and Resveratrol in Medicine
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Proteoglycans and glycosaminoglycans research
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- Bone Metabolism and Diseases
- Glycosylation and Glycoproteins Research
- Biochemical Acid Research Studies
- Estrogen and related hormone effects
- Heme Oxygenase-1 and Carbon Monoxide
- Enzyme function and inhibition
- Peptidase Inhibition and Analysis
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Immune Response and Inflammation
Kosin University
2022-2024
Pusan National University
2006-2021
Seoul National University
2012-2019
Kyungpook National University
2007
Dongguk University
2007
Innate immunity provides the first line of defense through multiple mechanisms, including pyrogen production and cell death. While elevated body temperature during infection is beneficial to clear pathogens, heat stress (HS) can lead inflammation pathology. Links between pathogen exposure, HS, cytokine release, have been observed, but fundamental innate immune mechanisms driving pathology exposure HS remain unclear. Here, we use genetic approaches elucidate pathways in or LPS models. Our...
Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect SIRT7 on sorafenib acquired resistance remains unclear possible anti-tumor mechanism beyond this process HCC not clarified. We examined therapeutic potential determined whether it functions synergistically with to overcome chemoresistance.
Resistance to anticancer therapeutics occurs in virtually every type of cancer and becomes a major difficulty treatment. Although 5-fluorouracil (5FU) is the first-line choice therapy for gastric cancer, its effectiveness limited owing drug resistance. Recently, altered metabolism, including Warburg effect, preference glycolysis rather than oxidative phosphorylation energy production, has been accepted as pivotal mechanism regulating resistance chemotherapy. Thus, we investigated detailed...
// Eun Ji Lee 1 , Hae Seo 2 Ji-Hyeon Park Tam Thuy Lu Vo Sunho An Sung-Jin Bae Hoang Le Hye Shin Hee-Jun Wee Danbi 3 Young-Hwa Chung Jeong A. Kim 4 Myoung-Kuk Jang 5 Soo Hyung Ryu 6 Ensil Yu 7 Se Hwan 8 Zee Yong and Kyu-Won 1, 9 SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy Institute Pharmaceutical Sciences, Seoul National University, 08826, Korea Department Biochemistry, Keimyung University School Medicine, Daegu 42601, Internal Ulsan Asan Medical 05505, DNA Link...
Osimertinib, a selective third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), effectively targets the EGFR T790M mutant in non-small cell lung cancer (NSCLC). However, newly identified C797S mutation confers resistance to osimertinib. In this study, we explored role of pyruvate dehydrogenase 1 (PDK1) osimertinib resistance. Patients exhibiting initially displayed elevated PDK1 expression. Osimertinib-resistant lines with were established using A549,...
Ninjurin1 is a homotypic adhesion molecule that contributes to leukocyte trafficking in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, vivo gene deficiency studies have not yet been done. Here, we constructed knock-out (KO) mice and investigated the role on under inflammation conditions such as EAE endotoxin-induced uveitis. KO attenuated susceptibility by reducing recruitment into injury regions spinal cord showed less leukocytes inflamed...
Scleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and activated non-regulated inflammatory cells cytokines. Echinochrome A (EchA), a natural pigment isolated from sea urchins, has been demonstrated to have antioxidant activities beneficial effects in various models. The present study demonstrates for first time that EchA treatment alleviates bleomycin-induced scleroderma normalizing dermal thickness suppressing collagen deposition vivo....
Disruption of colonic homeostasis caused by aberrant M1/M2 macrophage polarization and dysbiosis contributes to inflammatory bowel disease (IBD) pathogenesis. However, the molecular factors mediating are not well characterized. Here, we found that Ninjurin1 (Ninj1) limits colon inflammation regulating microbiota composition under homeostatic conditions during colitis development. Ninj1 deletion in mice induced hypersusceptibility colitis, with increased prevalence colitogenic Prevotellaceae...
Most cancer cells primarily produce their energy through a high rate of glycolysis followed by lactic acid fermentation even in the presence abundant oxygen. Pyruvate dehydrogenase kinase (PDK) 1, an enzyme responsible for aerobic via phosphorylating and inactivating pyruvate (PDH) complex, is commonly overexpressed tumors recognized as therapeutic target colorectal cancer. Hemistepsin A (HsA) sesquiterpene lactone isolated from Hemistepta lyrata Bunge (Compositae). Here, we report that HsA...
Abstract Objectives Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date. Methods Based on clinical clues, we hypothesized that 5-hydroxytryptamine (5-HT) hyperactivation implicated in the pathogenic causes of ME/CFS and associated symptoms. We experimentally evaluated this hypothesis series mouse models. Results High-dose selective serotonin reuptake inhibitor (SSRI) treatment...
Oxidative stress contributes to the onset of chronic diseases in various organs, including muscles. Morroniside, a type iridoid glycoside contained
Endometriosis is a gynecological disease prevalent in women of reproductive age, and it characterized by the ectopic presence growth eutopic endometrium. The pathophysiology diagnostic biomarkers endometriosis have not yet been comprehensively determined. To discover molecular markers pathways underlying pathogenesis endometriosis, we identified differentially expressed genes (DEGs) three Gene Expression Omnibus microarray datasets (GSE11691, GSE23339, GSE7305) performed gene set enrichment...
Metabolic disorder is a major characteristic of cancer cells, and controlling genes involved in metabolic shifts can be an effective strategy for treatment. Andrographolide (AG), diterpenoid lactone, widely recognized as natural anticancer drug due to its ability inhibit growth. The present study aimed investigate the mechanism underlying mitochondrial‑mediated effect AG by inhibiting pyruvate dehydrogenase kinase 1 (PDK1) expression lung cells. Cells were treated with PDK1 mRNA protein was...
Ninjurin1 is a transmembrane protein involved in macrophage migration and adhesion during inflammation. It was recently reported that repression of attenuated the lipopolysaccharide (LPS)-induced inflammatory response macrophages; however, precise mechanism by which modulates LPS-induced inflammation remains poorly understood. In present study, we found interaction between LPS contributed to response. Notably, pull-down assays using lysates from HEK293T cells transfected with human or mouse...
Cirrhosis, the end-stage of hepatic fibrosis, is not only life-threatening by itself, but also a causative factor liver cancer. Despite efforts to develop treatment for there are no approved agents as anti-fibrotic drugs date. In present study, we aimed investigate effect AMP-activated protein kinase (AMPK) activator, HL156A. A mouse model thioacetamide (TAA)-induced fibrosis was used examine HL156A in vivo. Mice received either TAA alone or combination and intraperitoneally total duration 6...
// Tam Thuy Lu Vo 1 , Ji-Hyeon Park Ji Hae Seo 2 Eun Lee Hoon Choi Sung-Jin Bae Hoang Le Sunho An Hye Shin Hee-Jun Wee and Kyu-Won Kim 1, 3 SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy The Institute Pharmaceutical Sciences, Seoul National University, 08826, Korea Department Biochemistry, School Medicine, Keimyung Daegu 42601, Crop Biotechnology Institute, GreenBio Science Technology, Pyeongchang 25354, Correspondence to: Kim, email: qwonkim@snu.ac.kr Keywords:...
Benign prostatic hyperplasia (BPH), a common disease in elderly males, is accompanied by non-malignant growth of prostate tissues, subsequently causing hypoxia and angiogenesis. Although VEGF-related angiogenesis one the therapeutic targets cancer, there no previous study targeting for treatment BPH. Dihydrotestosterone (DHT)- induced expressions vascular endothelial factor (VEGF) epithelial RWPE-1 cells human umbilical (HUVECs). Conditioned media (CM) from DHT-treated were transferred to...
In cancer cells, aerobic glycolysis rather than oxidative phosphorylation (OxPhos) is generally preferred for the production of ATP. many cancers, highly expressed pyruvate dehydrogenase kinase 1 (PDK1) reduces activity (PDH) by inducing its E1α subunit (PDHA1) and subsequently, shifts energy metabolism from OxPhos to glycolysis. Thus, PDK1 has been regarded as a target anticancer treatment. Here, we report that ilimaquinone (IQ), sesquiterpene quinone isolated marine sponge Smenospongia...
Abstract Cancer is one of the main causes mortality in world. Many cancer cells produce ATP through high-level lactic acid fermentation catalyzed by lactate dehydrogenase (LDH), which converts pyruvic to acid. LDH plays a dominant role Warburg effect, wherein aerobic glycolysis favored over oxidative phosphorylation. Due high production level cells, LDH-targeting could be potential treatment strategy. A few approaches, such as drug treatment, reportedly inhibited activity. In this study, we...