A5042426937- Atherosclerosis and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Cancer Research and Treatments
- Redox biology and oxidative stress
- Metabolism and Genetic Disorders
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Biomedical Research and Pathophysiology
- Autophagy in Disease and Therapy
- Erythrocyte Function and Pathophysiology
- Mechanisms of cancer metastasis
- Signaling Pathways in Disease
- Lipid metabolism and disorders
- Ubiquitin and proteasome pathways
Ewha Womans University
2016-2025
Seoul National University
2000-2025
Hallym University Dongtan Sacred Heart Hospital
2025
Andong National University
2025
Seoul National University Bundang Hospital
2025
Ewha Womans University Medical Center
2004-2024
National Cancer Center
2010-2023
Korea Research Institute of Bioscience and Biotechnology
2000-2023
Baewha Women's University
2004-2023
Harvard University
2010-2017
Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are most prominent features of atherosclerosis. To understand pathophysiology atherosclerotic disease, we need to characteristics lipid-laden foamy macrophages in during Objective: We sought examine transcriptomic profiles nonfoamy isolated from intima. Methods Results: Single-cell RNA sequencing analysis CD45 + leukocytes murine aorta revealed that there macrophage subpopulations with...
Defects in the renal fatty acid oxidation (FAO) pathway have been implicated development of fibrosis. Although, compared with young kidneys, aged kidneys show significantly increased fibrosis impaired kidney function, mechanisms underlying effects aging on not investigated. In this study, we investigated peroxisome proliferator–activated receptor α (PPAR ) and FAO as regulators age-associated The expression PPAR pathway–associated proteins decreased accumulation lipids tubular epithelial...
Ischemic stroke is the leading cause of immortal disability and death worldwide. For treatment in acute phase, it necessary to control excessive reactive oxygen species (ROS) damage during ischemia/reperfusion (I/R). Microglia are well known be closely associated with ROS response early stage I/R. However, precise roles microglia mitigating damage, molecular markers heterogenetic I/R damaged brain has not been clarified. Here, we identified a new type injured brain. Single-cell RNA...
Abstract Objective To investigate the molecular mechanisms of antiarthritic effects bee venom (BV) and melittin (a major component BV) in a murine macrophage cell line (Raw 264.7) synoviocytes obtained from patients with rheumatoid arthritis. Methods We evaluated BV rat model carrageenan‐induced acute edema paw chronic adjuvant‐induced The inhibitory on inflammatory gene expression were measured by Western blotting, generation prostaglandin E 2 (PGE ) nitric oxide (NO) intracellular calcium...
To study the role of epithelial calcium channel transient receptor potential vanilloid type 6 (TRPV6) and calcium-binding protein calbindin-D9k in intestinal absorption, TRPV6 knockout (KO), KO, TRPV6/calbindin-D9k double-KO (DKO) mice were generated. DKO have serum levels similar to those wild-type (WT) (∼10 mg Ca2+/dl). In KO mice, however, there is a 1.8-fold increase PTH (P < 0.05 compared with WT). Active transport was measured using everted gut sac method. Under low dietary...
AMP-activated protein kinase (AMPK) plays an important role in regulating whole body energy homeostasis. Recently, it has been demonstrated that berberine (BBR) exerts antiobesity and antidiabetic effects obese diabetic rodent models through the activation of AMPK peripheral tissues. Here we show BBR improves lipid dysregulation fatty liver mice central actions. In db/db ob/ob mice, treatment reduced weight, hepatic plasma triglyceride, cholesterol contents. muscle promoted activity acid...
Summary Background Histone deacetylase (HDAC) inhibition has been demonstrated to change the expression of a restricted set cellular genes. T cells are essential in pathogenesis allergen‐induced airway inflammation. It was recently reported that treatment with HDAC inhibitors induces cell‐suppressive effect. Objective The purpose this study determine whether trichostatin A (TSA), representative inhibitor, would reduce inflammation mouse asthma model. Methods BALB/c mice were...
Microvascular dysfunction is a major cause of impaired wound healing seen in diabetic patients. Therefore, reestablishment structural and functional microvasculature could be beneficial to promote these Angiopoietin-1 (Ang1) specific growth factor functioning generate stable vasculature through the Tie2 Tie1 receptors. Here we determined effectiveness cartilage oligomeric matrix protein (COMP)-Ang1, soluble, stable, potent form Ang1, on promotion cutaneous wounds mice. An excisional...
Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, is expressed at high levels in adipose tissues obese Zucker diabetic fatty (fa/fa) rats, and CTRP1 expression induced by proinflammatory cytokines, including TNF-alpha IL-1beta. In present study, we investigated stimulation aldosterone production CTRP1, since it was observed that specifically zona glomerulosa adrenal cortex, where produced. Increased cells human cortical cell line H295R dose-dependent. Expression...
Abstract The role of peroxisome proliferator–activated receptor α (PPAR-α) in innate host defense is largely unknown. In this study, we show that PPAR-α essential for antimycobacterial responses via activation transcription factor EB (TFEB) and inhibition lipid body formation. deficiency resulted an increased bacterial load exaggerated inflammatory during mycobacterial infection. agonists promoted autophagy, lysosomal biogenesis, phagosomal maturation, antimicrobial against Mycobacterium...
Superoxide dismutase 1 (SOD1) binds copper and zinc ions is one of three superoxide dismutases responsible for destroying free radicals in the body. Reactive oxygen species (ROS), including radicals, play important roles colitis. However, role SOD1 oxidative stress under colitis remains unclear. Here, we examined DSS-induced mouse model deficiency resulted severe with body weight loss, epithelial barrier disruption decreased antioxidant enzyme activities. The levels neutrophils, monocytes,...
Rationale: Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress. Objective: Although Prdx2 proposed retard atherosclerosis development, no direct evidence mechanisms have reported. Methods Results: We show that is highly expressed in endothelial immune cells atherosclerotic lesions blocked the increase of endogenous H O by atherogenic stimulation. Deficiency apolipoprotein E–deficient...
Abstract Heat shock protein (Hsp)70 is a molecular chaperone that maintains homoeostasis during cellular stress through two opposing mechanisms: refolding and degradation. However, the mechanisms by which Hsp70 balances these functions under conditions remain unknown. Here, we demonstrate preferentially facilitates after stress, gradually switching to degradation via mechanism dependent on ARD1-mediated acetylation. During early response, immediately acetylated ARD1 at K77, binds...
Histone acetylation has been shown to be involved in expression of a restricted set cellular genes including various proinflammatory molecules. We aimed investigate the relationship between histone and atherosclerosis.In low-density lipoprotein (LDL) receptor-deficient (Ldlr(-/-)) mice fed an atherogenic diet for 4 or 8 weeks, trichostatin A (TSA), specific deacetylase inhibitor, exacerbated atherosclerosis without alteration on plasma lipid profiles. When we assayed effects TSA expressions...
Lipid accumulation in vascular endothelial cells may play an important role the pathogenesis of atherosclerosis obese subjects. We showed previously that alpha-lipoic acid (ALA) activates AMP-activated protein kinase (AMPK) and reduces lipid skeletal muscle rats. Here, we investigated whether ALA improves dysfunction rats by activating AMPK cells.Endothelium-dependent relaxation was impaired, number apoptotic higher aorta compared with control In addition, triglyceride peroxide levels were...
Abstract We searched for potential suppressors of tumor metastasis by identifying the genes that are frequently down-regulated in hepatocellular carcinomas (HCC) while being negatively correlated with clinical parameters relevant to metastasis, and we report here on identification N-myc downstream regulated gene 2 (NDRG2) as a promising candidate. NDRG2 expression was significantly reduced HCC compared nontumor or normal liver tissues [87.5% (35 40) 62% (62 100) at RNA protein levels,...
Vascular endothelial growth factor (VEGF) and hepatocyte (HGF) are potent angiogenic factors that have been used clinically to induce angiogenesis. However, concerns raised about VEGF because of its proinflammatory actions, which include enhancing the adhesion leukocytes cells. We examined possible antiinflammatory effects HGF on vasculature. HGF, unlike VEGF, did not alter leukocyte Instead it inhibited VEGF-induced leukocyte-endothelial cell interactions expression intercellular molecule-1...