A5100406799- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Appendicitis Diagnosis and Management
- Endometriosis Research and Treatment
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Peptidase Inhibition and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- RNA modifications and cancer
- Minimally Invasive Surgical Techniques
- Cervical Cancer and HPV Research
- Hernia repair and management
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Surgical Simulation and Training
- Nuclear and radioactivity studies
- Anatomy and Medical Technology
- Airway Management and Intubation Techniques
- Intestinal and Peritoneal Adhesions
Hanyang University
2024
Seoul National University
2010-2024
Chung-Ang University Hospital
2022-2024
Soonchunhyang University Hospital
2024
Pusan National University
2016-2024
Hannam University
2022-2024
Sungkyunkwan University
2001-2024
Ulsan University Hospital
2019-2022
Seoul National University Hospital
2008-2022
Pohang University of Science and Technology
2022
During the last few decades, considerable research on diabetic wound healing strategies has been performed, but complete remains an unsolved problem, which constitutes enormous biomedical burden. Herein, hyaluronic acid (HA)/poly(lactic‐ co ‐glycolic acid, PLGA) core/shell fiber matrices loaded with epigallocatechin‐3 ‐O‐ gallate (EGCG) (HA/PLGA‐E) are fabricated by coaxial electrospinning. HA/PLGA‐E composed of randomly‐oriented sub‐micrometer fibers and have a 3D porous network structure....
Abstract Heat shock protein (Hsp)70 is a molecular chaperone that maintains homoeostasis during cellular stress through two opposing mechanisms: refolding and degradation. However, the mechanisms by which Hsp70 balances these functions under conditions remain unknown. Here, we demonstrate preferentially facilitates after stress, gradually switching to degradation via mechanism dependent on ARD1-mediated acetylation. During early response, immediately acetylated ARD1 at K77, binds...
Neural stem cells (NSCs) have the ability to generate a variety of functional neural cell types and high potential for neuronal regeneration recovery. Thus, they been recognized as best source therapy neurodegenerative diseases, such Parkinson's disease (PD). Owing possibility paracrine effect-based therapeutic mechanisms easier clinical accessibility, extracellular vesicles (EVs), which possess very similar bio-functional components from their cellular origin, emerged alternatives in...
Background: The incidence, clinical manifestations, and contributory factors in ethambutol-induced optic neuropathy (EON) have not been widely studied. Methods: A retrospective chart review of 857 patients who took ethambutol for treatment tuberculosis identified 89 complained decreased vision after initiation were therefore referred to the ophthalmology clinic Seoul National University Hospital, Korea, between January 2003 December 2005. Information was extracted regard systemic illnesses,...
Abstract Background Dynamically altered microglia play an important role in the progression of Alzheimer’s disease (AD). Here, we found a close association metabolic reconfiguration with increased hippocampal glucose uptake on [ 18 F]fluorodeoxyglucose (FDG) PET. Methods We used AD animal model, 5xFAD, to analyze metabolism using both FDG PET and ex vivo test. Cells hippocampus were isolated perform single-cell RNA-sequencing (scRNA-seq). The molecular features cells associated analyzed at...
This study aimed to evaluate the therapeutic role of lymphadenectomy in patients surgically treated for clinically early-stage epithelial ovarian cancer (EOC).
In human epithelial ovarian cancer (EOC), various miRNAs can function as either oncogenes or tumor suppressor genes. We investigated known to be involved in EOC progression and analyzed their expression tissues serum-derived exosomes from benign serous cystadenoma, borderline tumor, low-grade cancer, high-grade patients (HGSO). The HGSO group was divided based on the platinum-free interval, which is defined duration completion of platinum-based chemotherapy recurrence. also mRNA levels...
Abstract Background The Laparoscopic Approach to Cervical Cancer trial and Surveillance, Epidemiology, End Results program database study demonstrated that minimally invasive radical hysterectomy was inferior abdominal in terms of disease recurrence survival. Among risk factors related poor prognosis after surgery (MIS), tumour spillage during intracorporeal colpotomy became a significant issue. Thus, we designed this evaluate the efficacy safety using an endoscopic stapler for early-stage...
We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys. After searching 878 studies on AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 13 were classified as comprehensive procedure information. In information, there was a higher preference optimal cytoreduction defined no visible tumor (44%) compared residual tumors <1 cm (38%) or <2 (2%) omental disease...
This study aims to evaluate the drug distribution, tissue concentrations, penetration depth, pharmacokinetic properties, and toxicities after rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) in pigs. Because relevant medical devices have not been introduced, we developed our prototype of (PIPAC) RIPAC by adding a conical pendulum motion device for rotating nozzle. PIPAC were conducted using 150 ml 1% methylene blue distribution 3.5 mg doxorubicin 50 0.9% NaCl...
Purpose To report an unusual presentation of disseminated, intraocular, extranodal natural killer/T-cell lymphoma, nasal type (NK/T-cell lymphoma), originating from NK/T-cell lymphoma. Methods Case report. Results A 63-year-old woman who had been treated with systemic chemotherapy and radiotherapy for lymphoma in the cavity presented vitreous haze right eye. Despite anti-inflammatory therapy, eye showed poor clinical response received diagnostic vitrectomy. The opacity resembled a thin...
Arrest defective 1 (ARD1) is an acetyltransferase that highly conserved across organisms, from yeasts to humans. The high homology and widespread expression of ARD1 multiple species tissues signify it serves a fundamental role in cells. Human (hARD1) has been suggested be involved diverse biological processes, its cell proliferation cancer development recently drawing attention. However, the subcellular localization relevance cellular function remain largely unknown. Here, we have...
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been suggested as an alternative option for treating peritoneal carcinomatosis (PC). Even with its clinical advantages, the current PIPAC system still suffers from limitations regarding drug distribution area and penetration depth. Thus, we evaluated new using a novel prototype, compared performance to results previous studies related MIP® indirectly because is currently not available purchase in market. The developed prototype...
Vascular diseases, including ischemic conditions and restenosis, pose significant challenges in clinical practice. Restenosis, the re-narrowing of blood vessels after interventions such as stent placement, remains a major concern despite advances medical interventions. Addressing these requires innovative approaches that promote vascular regeneration prevent restenosis. By leveraging capabilities three-dimensional (3D) printing technology, artificial with lumen can be precisely constructed...
Our research introduces a novel screening method to identify antibodies that can suppress cell proliferation and induce apoptosis.
Aerobic glycolysis is a hallmark of glucose metabolism in cancer. Previous studies have suggested that cancer cell-derived extracellular vesicles (EVs) can modulate adjacent cells and promote disease progression. We hypothesized EVs originating from recipient to induce cell proliferation an aggressive phenotype. Two breast lines with different levels glycolytic activity, MDA-MB-231 the claudin-low subtype MCF7 luminal type, were selected cocultured as cells, respectively, using indirect...
<h3>Objective</h3> Evidence on recurrence patterns after bevacizumab in epithelial ovarian cancer is still insufficient. The aim of this study was to evaluate treatment with as second-line patients platinum-sensitive, recurrent cancer. <h3>Methods</h3> We retrospectively identified who relapsed ≥6 months primary consisting surgery and platinum-based chemotherapy between January 2008 June 2019. Only those received doublet or without were included (n=192). To adjust confounders, we conducted...
ARD1 is an acetyltransferase with several variants derived from alternative splicing. Among variants, mouse ARD1225 (mARD1225), ARD1235 (mARD1235), and human (hARD1235) have been the most extensively characterized are known to different biological functions. In present study, we demonstrated that mARD1225, mARD1235, hARD1235 conserved autoacetylation activities, they selectively regulate distinct roles of in tumorigenesis. Using purified recombinants for found undergo similar target site at...
Jung Hun Lee, Tae Jun Yang, Seon Wook Kim, Joo Yong Jeong, Young Ma, Jae Oh, Jeong Choi, Eun Ji and Tung Shuen Wei. Korean J Acupunct 2015;32:199-207. https://doi.org/10.14406/acu.2015.023
Abstract Background This study aims to evaluate the incidence of and identify risk factors for gastrointestinal (GI) genitourinary (GU) fistula or perforation formation with without bevacizumab in patients recurrent cervical cancer who underwent pelvic radiation therapy (RT). Methods Medical records previously RT between 2007 2020 were retrospectively reviewed. Clinicopathological compared groups that are stratified according to: 1) fistula/perforation (+) versus (-); 2) plus conventional...