A5002973439- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Electron Spin Resonance Studies
- 3D Printing in Biomedical Research
- Pharmacological Effects of Natural Compounds
- Advanced Chemical Sensor Technologies
- Endoplasmic Reticulum Stress and Disease
- Tissue Engineering and Regenerative Medicine
- Healthcare and Venom Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Hypoxia, and Metabolism
- Insect and Pesticide Research
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Microfluidic and Capillary Electrophoresis Applications
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Analysis
- Advanced Computing and Algorithms
- Biosensors and Analytical Detection
- Polydiacetylene-based materials and applications
- Drug-Induced Hepatotoxicity and Protection
- Management of metastatic bone disease
- Phytochemical Studies and Bioactivities
- Edible Oils Quality and Analysis
- Synthesis and Biological Evaluation
Pusan National University
2002-2023
Dongguk University
2009
Endothelial progenitor cell (EPC)-based stem therapy is a promising therapeutic strategy for vascular diseases. However, continuous in vitro expansion clinical studies induces the loss of EPC functionality due to aging. In this study, we investigated effects StemRegenin-1 (SR-1), an antagonist aryl hydrocarbon receptor (AhR), on replicative senescence EPCs. We found that SR-1 maintained expression surface markers, including such as CD34, c-Kit, and CXCR4. Moreover, long-term-treated EPCs...
Diabetes and its complications affect the younger population are associated with a high mortality rate; however, early diagnosis can contribute to selection of appropriate treatment regimens that reduce mortality. Although diabetes via exhaled breath has great potential for diagnosis, research on such is restricted disease detection, requiring in-depth examination diagnose classify diseases their complications. This study demonstrates use an artificial neural processing-based bioelectronic...
Anterior gradient protein 2 homolog (AGR2), an endoplasmic reticulum protein, is secreted in the tumor microenvironment. AGR2 a member of disulfide isomerase family, highly expressed multiple cancers, and promotes cancer metastasis. In this study, we found that etravirine, which non-nucleoside reverse transcriptase inhibitor, could induce degradation via autophagy. Moreover, etravirine diminished proliferation, migration, invasion vitro. orthotopic xenograft mouse model, combination...
Vascular regeneration plays a critical role in the treatment of cardiovascular diseases and tissue engineering applications. In this study, we fabricated characterized statin/curcumin-loaded nanoparticles for potential applications vascular regeneration. The exhibited consistent spherical shape sizes, indicating reproducibility stability fabrication process. sustained release loaded drugs from indicated their suitability controlled prolonged drug delivery. Biocompatibility assessments...
Vascular diseases, including ischemic conditions and restenosis, pose significant challenges in clinical practice. Restenosis, the re-narrowing of blood vessels after interventions such as stent placement, remains a major concern despite advances medical interventions. Addressing these requires innovative approaches that promote vascular regeneration prevent restenosis. By leveraging capabilities three-dimensional (3D) printing technology, artificial with lumen can be precisely constructed...
This study investigated the protective effect of glutathione (GSH), an antioxidant drug, against doxorubicin (DOX)-induced cardiotoxicity. Human cardiac progenitor cells (hCPCs) treated with DOX (250 to 500 nM) showed increased viability and reduced ROS generation apoptosis GSH treatment (0.1 1 mM) for 24 h. In contrast nM group, pERK levels were restored in group co-treated suppression ERK signaling improved hCPCs' survival. Similarly previous results, potency hCPCs 100 which did not affect...
Abstract Cardiotoxicity caused by doxorubicin (DOX) is an important issue to consider for both patients and doctors who require DOX. DOX-induced cardiotoxicity closely associated with cardiomyocyte death dysfunction. To prevent cardiotoxicity, many studies have been conducted on new therapeutic strategies, including the discovery of novel functional modulators such as antioxidant drugs restore loss function transplanted or residual cardiac cells in heart. We investigated whether glutathione...
Abstract Mitochondria are intracellular organelles that regulate cell survival and death, hyperglycemia modulates mitochondrial function in endothelial cells. In the current study, we have discovered high glucose (HG) treatment reduces FUNDC1 ( FUN14 domain containing 1 ) expression mitochondria inhibits proteasomal degradation of COX-IV, regulates complexes I IV activity ATP synthesis. depletion HG affects synthesis promotes damage through loss membrane potential ROS (Reactive Oxygen...