A5018555350- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Endometriosis Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- CRISPR and Genetic Engineering
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Intestinal and Peritoneal Adhesions
- Photonic and Optical Devices
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Cancer Risks and Factors
- Advanced MEMS and NEMS Technologies
- Intergenerational Family Dynamics and Caregiving
- Peptidase Inhibition and Analysis
- Korean Peninsula Historical and Political Studies
- Chemokine receptors and signaling
Seoul National University
2021-2024
CHA University
2024
Seoul National University Hospital
2021-2024
Sogang University
2022
Kyung Hee University Medical Center
2021
Kyung Hee University
2021
New Generation University College
2021
National University College
2021
Government of the Republic of Korea
2021
ORCID
2021
In the 2023 series, we summarized major clinical research advances in gynecologic oncology based on communications at conference of Asian Society Gynecologic Oncology Review Course. The review consisted 1) Endometrial cancer: immune checkpoint inhibitor, antibody drug conjugates (ADCs), selective inhibitor nuclear export, CDK4/6 inhibitors WEE1 poly (ADP-ribose) polymerase (PARP) inhibitors. 2) Cervical surgery low-risk early-stage cervical cancer, therapy for locally advanced stage and...
This study aims to evaluate the drug distribution, tissue concentrations, penetration depth, pharmacokinetic properties, and toxicities after rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) in pigs. Because relevant medical devices have not been introduced, we developed our prototype of (PIPAC) RIPAC by adding a conical pendulum motion device for rotating nozzle. PIPAC were conducted using 150 ml 1% methylene blue distribution 3.5 mg doxorubicin 50 0.9% NaCl...
4004 Background: Currently no evidence that SLC in AGC patients will result substantial prolongation of survival when compared to BSC exists, and there is potential for toxicity from the treatment. The efficacy safety using either single-agent docetaxel or irinotecan was evaluated a randomized phase III trial. Methods: Two-hundreds two with AGC, one prior chemotherapy regimen(s) involving both fluoropyrimidines platinum, an Eastern Cooperative Oncology Group performance status (PS) 0 1 were...
To attain the immortal phenotype, cancer cells must overcome mitotic clock. Telomerase activity has been identified to be activated in malignant tumors including breast cancer. was evaluated 71 tissues and paired normal with TRAP (telomerase repeat amplification protocol) assay. calculated translated into arbitrary units by computer-assisted densitometry control of telomerase 293 cell line. In 59 activity, terminal restriction fragment (TRF) lengths were measured using Southern blotting....
Drug resistance is a major cause of treatment failure for small-molecule cancer chemotherapies, despite the advances in combination therapies, drug delivery systems, epigenetic drugs, and proteolysis-targeting chimeras. Herein, we report use resistance-free cytotoxic nanodrug as an alternative to drugs. The present nanodrugs comprise 2 nm core gold nanoparticles (AuNPs) covered completely with multivalent hydrocarbon chains final diameter ∼10 single molecules. This hydrophobic drug-platform...
This study investigated the uptake rate of risk-reducing salpingo-oophorectomy (RRSO) and surgical outcomes germline BRCA1/2 mutation carriers at Seoul National University Hospital (SNUH).We examined records 824 women who underwent gene testing SNUH between 2005 2020. Among them, we identified with a pathogenic on either BRCA1 or BRCA2 gene, excluded ovarian cancer patients. Characteristics participants RRSO (RRSO group) were compared to those did not (non-RRSO group). Surgical pathologic...
The complex of C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, ligand 12 (CXCL12), plays an essential role in cancer cell proliferation, invasion, metastasis. These are emerging therapeutic targets, recent studies have reported that inhibition CXCL12-CXCR4 signaling pathway enhances the effects immune checkpoint inhibitors. Thus, we aimed to investigate tissue expression CXCL12 CXCR4 high-grade serous ovarian carcinoma (HGSOC) determine their potential as prognostic markers.We used...
3524 Background: A regimen consisting of capecitabine and oxaliplatin (COX) is widely used in Korea the first-line treatment metastatic colorectal cancer (MCRC). S-1 may have considerable activity compared with capecitabine. Phase I II studies showed that plus (SOX) might at least comparable COX MCRC. The aim study was to evaluate whether SOX noninferior terms progression free survival (PFS) patients previously untreated systemic therapy for Our hypothesis non-inferior if upper limit 95%...
Abstract Background Endometriosis (EMS) can be implanted everywhere, especially in pelvic organs. EMS asymptomatic, but it result pain and infertility by inducing local inflammation adhesion. The prevalence of is about 10% reproductive-age women higher with or infertility. For young patients ovarian EMS, laparoscopic cystectomy effective relieving preventing recurrence. However, there a concern that the reserve would decrease after operation because removal part normal tissue thermal damage...
LBA4032 Background: Currently, there is no standard regimen for palliative chemotherapy in metastatic, unresectable biliary tract cancer (BTC). A phase II trial of erlotinib monotherapy showed a promising anti-tumor activity BTC with tolerable toxicity. Additionally, gemcitabine + demonstrated superior efficacy when compared to alone pancreatic cancer. Hence, we conducted III compare between GEMOX vs GEMOX+erlotinib (Tarceva [T]) (GEMOX/T) as first-line unresectable, metastatic BTC. Methods:...
e14653 Background: Biliary tract carcinoma (BTC) is rare in the West, but not uncommon Asia and highly fatal malignancy. While gemcitabine-based regimen considered as reasonable option for first-line treatment, most patients progress eventually. VEGF expression related with poor outcome BTC. Therefore, we conducted phase II study to evaluate efficacy safety of sunitinib second-line treatment previously treated unresectable, metastatic Methods:This was a prospective, single-arm, multicenter,...
Abstract The preservation of ovarian reserve during laparoendoscopic single-site (LESS) cystectomy is crucial for reproductive-age women. This study was a single-blinded, single-center, and randomized controlled trial to evaluate the effect hemostatic agents on hemostasis LESS cystectomy. Patients with unilateral cyst were agent coagulation groups according method. Afterwards, patients underwent cystectomy, performed after excision assigned If not completed within 10 min. After discharge,...
Even though the injection of diluted vasopressin into uterus is expected to reduce intraoperative bleeding with decreased adverse effects during robot-assisted laparoscopic myomectomy (RALM), there a lack relevant trials show its effect and safety. Thus, this study was designed compare safety on bleedings based dilution levels constant volumes RALM. This randomised controlled pilot trial, where total 39 patients will be randomly divided three experimental groups in 1:1:1 ratio. All...
Abstract This article introduces a new aspect of skill profiles, ‘relational skills’, to examine how occupation-oriented relational skills can activate different perceptions pay equity between genders and influence support for the welfare state. Relational refer degree which worker possesses pertaining human interactions those regarding operation machines or tools. We ratio differently influences justice in system men women this shapes their attitudes. By analyzing levels redistribution 30...
<h3>Introduction/Background</h3> Tumor progression induces a hypermetabolic state in the tumor microenvironment, affecting lipolysis and protein degradation. This study explores impact of baseline sarcopenic status changes body composition during cervical cancer treatment on survival outcomes. <h3>Methodology</h3> Patients diagnosed with stage IB1-IVB receiving primary concurrent chemoradiation therapy (CCRT) between January 2002 June 2022 were included. Exclusions involved prior radical...
This study attempted to assess the whitening activities of Salvia plebeia R. Br. and Centella asiatica extracts which were provided by MEIDEME CO., LTD., their safety was confirmed through cell viability testing. The evaluated inhibition melanin synthesis reduction whitening-related transcription factors protein production. results found that no statistically significant cytotoxicity observed at 10㎍/㎖, 20㎍/㎖and 40㎍/㎖. In addition, production decreased 28.4% BR extract(SCE) factors,...