Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due implications therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, which the kinetics guest molecule can be fine-tuned by control over cross-linking density. The polymer nanogel precursor is based on random copolymer contains oligoethyleneglycol (OEG) pyridyldisulfide (PDS) units as...

Abstract Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. However, translating nanoparticle-based into clinical applications still remains a challenge due to difficulty in regulating interactions on interfaces between biological systems. Here, we present targeting strategy for incorporated with supramolecularly pre-coated recombinant fusion protein which HER2-binding affibody combines glutathione- S...

Achieving spatiotemporal control of molecular self-assembly associated with actuation biological functions inside living cells remains a challenge owing to the complexity cellular environments and lack characterization tools. We present, for first time, organelle-localized peptide amphiphile as powerful strategy controlling fate. A phenylalanine dipeptide (FF) mitochondria-targeting moiety, triphenyl phosphonium (Mito-FF), preferentially accumulates mitochondria reaches critical aggregation...

Metal-organic framework (MOF) nanoparticles with high porosity and greater tunability have emerged as new drug delivery vehicles. However, premature release still remains a challenge in the MOF system. Here, we report an enzyme-responsive, polymer-coated gatekeeper system using hyaluronic acid (HA) PCN-224 nanoMOF. The external surface of nanoMOF can be stably covered by HA through multivalent coordination bonding between Zr cluster carboxylic HA, which acts gatekeeper. allows selective...

Metal-organic framework (MOF) nanoparticles have recently emerged as a promising vehicle for drug delivery with high porosity and feasibility. However, employing MOF-based system remains challenge due to the difficulty in controlling interfaces of particles biological environment. In this paper, protein corona-blocked Zr6 -based MOF (PCN-224) are presented targeted cancer therapy efficiency. The unmodified PCN-224 surface is precoated glutathione transferase (GST)-fused targetable affibody...

Lysosomes remain powerful organelles and important targets for cancer therapy because cell proliferation is greatly dependent on effective lysosomal function. Recent studies have shown that membrane permeabilization induces death an way to treat by bypassing the classical caspase-dependent apoptotic pathway. However, most lysosome-targeted anticancer drugs very low selectivity cells. Here, we show intra-lysosomal self-assembly of a peptide amphiphile as technique overcome this problem. We...

The stability of encapsulation in self-assembly systems is limited during blood circulation because a requisite concentration for assembly formation. For deliberate molecular design stable encapsulation, targeting, and triggered release, we have developed facile synthetic method highly stable, polymeric nanogels using simple intra/interchain cross-linking reaction. We show simple, emulsion-free the preparation biocompatible that provides ability to encapsulate hydrophobic guest molecules...

Amphiphilic polymers of different hydrophilic−lipophilic ratios were prepared by free radical polymerization using two monomers consisting triethylene glycol as the hydrophilic part and an alkyl chain connected disulfide bond hydrophobic part. These form micelle-like nanoassemblies in aqueous media can encapsulate drug molecules up to 14% their mass. In a reducing environment, these polymeric micelles disassemble dissolve water, since amphiphilic are converted into upon cleavage bond. This...

Exchange dynamics of lipophilic guest molecules, encapsulated in supramolecular nanoassemblies aqueous solutions, have implications evaluating the stability drug delivery vehicles. This is because exchange related to propensity a nanocarrier be leaky. We describe fluorescence resonance energy transfer (FRET) based method evaluate phase. utilized this analyze encapsulation polymeric nanogels and other amphiphilic nanoassemblies.

Herein, we introduce an indocyanine derivative (<bold>IR-Pyr</bold>) that is highly water soluble, exhibiting higher mitochondrial targetability and better photostability than IR-780.

Selective targeting of tumor cells and release drug molecules inside the microenvironment can reduce adverse side effects traditional chemotherapeutics because lower dosages required. This be achieved by using stimuli‐responsive targeted delivery systems. In present work, a robust simple one‐pot route is developed to synthesize polymer‐gatekeeper mesoporous silica nanoparticles noncovalent capping pores drug‐loaded nanocontainers with disulfide cross‐linkable polymers. The method offers very...

Abstract Natural polymers with abundant side functionalities are emerging as a promising binder for high‐capacity yet large‐volume‐change silicon anodes strong and reversible supramolecular interaction that originates from secondary bonding. However, the network solely based on hydrogen bonding is relatively vulnerable to repeated deformation has an insufficient diffusivity of lithium ions. Herein, reported facile but efficient way incorporating natural ionically conductive crosslinker,...

The mitochondrial pool of Hsp90 and its paralogue, TRAP1, suppresses cell death reprograms energy metabolism in cancer cells; therefore, TRAP1 have been suggested as target proteins for anticancer drug development. Here, we report that the actual protein mitochondria is current inhibitors cannot effectively inactivate because their insufficient accumulation mitochondria. To develop inhibitors, determined crystal structures human complexed with inhibitors. isopropyl amine inhibitor PU-H71 was...

Abstract Nanomedicines exploit the unusual physicochemical and biological properties of nanoparticles, including their nanoscopic size, high surface‐area‐to‐volume ratio, easy surface modification, biocompatibility. Among various therapeutic diagnostic applications nanomedicines, cancer‐targeted drug delivery systems (DDS) have been found to be a promising area research. Effective DDS rely on two major factors: slow sustained release chemotherapeutic drugs targeted tumor sites. Both...

This work demonstrates the design, synthesis, characterization, and study of electrochemical performance a novel binder for silicon (Si) anodes in lithium-ion batteries (LIBs). Polymeric binders with three different functional groups, namely, carboxylic acid (COOH), carboxylate (COO–), hydroxyl (OH), single polymer backbone have been synthesized characterized via 1H NMR FTIR spectroscopies. A systematic that involved varying ratio groups indicated material an acid-to-alcohol molar 60:40...

Self-assembly of peptides containing both l- and d-isomers often results in nanostructures with enhanced properties compared to their enantiomeric analogues, such as faster kinetics formation, higher mechanical strength, enzymatic stability. However, occurrence consequences the heterochiral assembly cellular microenvironment are unknown. In this study, we monitored amphiphilic inside cell, specifically mitochondria cancer cells, resulting refined morphological biological owing superior...

Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, are overexpressed in cells, limiting specificity and inducing severe side effects. To overcome these limitations, we constructed self-assembling targeting with intracellular oligomerization system. Intracellular aryl-dithiol-containing peptide occurred only inside the mitochondria of due to selective localization...

Intracellular assemblies play vital roles in maintaining cellular functions through structural recognition‐mediated interactions. The introduction of artificial structures has garnered substantial interest modulating via activation/inhibition interactions with biomacromolecules. However, the uptake these high‐molecular‐weight may limit their performance. Recently, intracellular chemical‐reaction‐induced self‐assembly emerged as a promising strategy for generating situ nanostructures...

Surface modification of MOF particle for overcoming biological barriers.

Triblock rigid-flexible dendritic block molecules consisting of a rigid aromatic segment as stem segment, carbohydrate-branched dendrons flexible head, and hydrophobic alkyl chain were synthesized characterized. The carbohydrate conjugate molecule based on methyl group tail, in the solid state, self-assembles into 1D nanostructure, whereas longer tail 2D nanosheets, confirmed by X-ray scatterings. In aqueous solution, however, both observed to self-assemble carbohydrate-coated cylindrical...

We have prepared functionalized nanoporous thin films from a polystyrene-block-polyethylene oxide block copolymer, which was made cleavable due to the intervening disulfide bond. The cleavage reaction of bond leaves behind free thiol groups inside nanopores polystyrene film. This film can be used as template for generating gold nanoring structures. strategy provide facile method form highly ordered array biopolymer or metal−polymer composite