A5100331515- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Fusion materials and technologies
- Solidification and crystal growth phenomena
- Bone Tissue Engineering Materials
- Nuclear Materials and Properties
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
- Collagen: Extraction and Characterization
- Monoclonal and Polyclonal Antibodies Research
- Spectroscopy and Chemometric Analyses
- Synthesis and properties of polymers
- Intermetallics and Advanced Alloy Properties
- Synthesis and Biological Evaluation
- Advanced biosensing and bioanalysis techniques
- Tissue Engineering and Regenerative Medicine
- Lipid Membrane Structure and Behavior
- Electrospun Nanofibers in Biomedical Applications
- Legionella and Acanthamoeba research
- Carbon Nanotubes in Composites
- Advanced Vision and Imaging
- Bioactive Compounds and Antitumor Agents
- Bacterial biofilms and quorum sensing
- Inflammasome and immune disorders
Brookhaven National Laboratory
2014-2025
Center for Functional Nanomaterials
2025
Konkuk University
2021-2024
Chung-Ang University
2018-2024
Ulsan National Institute of Science and Technology
2023-2024
Dongguk University
2020-2023
Citigroup
2017-2018
Imaging Center
2017-2018
Cornell University
2017-2018
Weill Cornell Medicine
2017-2018
Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, are overexpressed in cells, limiting specificity and inducing severe side effects. To overcome these limitations, we constructed self-assembling targeting with intracellular oligomerization system. Intracellular aryl-dithiol-containing peptide occurred only inside the mitochondria of due to selective localization...
Intracellular assemblies play vital roles in maintaining cellular functions through structural recognition‐mediated interactions. The introduction of artificial structures has garnered substantial interest modulating via activation/inhibition interactions with biomacromolecules. However, the uptake these high‐molecular‐weight may limit their performance. Recently, intracellular chemical‐reaction‐induced self‐assembly emerged as a promising strategy for generating situ nanostructures...
A unique nanoelectronic platform, based on single-walled carbon nanotubes (SWNTs), has been fabricated for measuring electrical transport in single-molecule DNA. We have tested 80 base pairs of single- and double-stranded DNA (ssDNA dsDNA, respectively) complex sequences. About a 25−40 pA current (at 1 V) was measured the dsDNA molecule covalently attached to SWNT electrode at its termini. In absence pair stacking, ssDNA carries feeble ∼1 or less. Gate-voltage-dependent I−V characteristics...
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, alveolar destruction, and airway vascular remodeling. However, the mechanisms that lead to these diverse alterations have not been defined.Objectives: We hypothesized IL-18 plays a central role in pathogenesis of lesions.Methods: generated lung-specific, inducible transgenic mice.Measurements Main Results: Here we demonstrate expression mature murine lung induces inflammation associated with...
Prostate-specific membrane antigen (PSMA)-targeted radiotherapy of prostate cancer (PCa) has emerged recently as a promising approach to the treatment disseminated disease. A small number ligands have been evaluated in patients, and although early tumor response is encouraging, relapse rate high these compounds localize parotid, salivary, lacrimal glands well kidney, leading dose-limiting toxicities adverse events affecting quality life. We envision that dual-target binding displaying...
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This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using phosphatidylcholine (PC)-based solid dispersion system. When fabricating PC-based dispersion, we employed mesoporous microparticles, as an adsorbent, disintegrants sticky nature PC respectively. The dispersions were prepared by solvent evaporation technique characterized Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry, X-ray powder...
Chicken meat is a popular food commodity that widely consumed worldwide. However, the shelf-life or quality maintenance of chicken major concern for industries because spoilage by microbial growth. The aim this study was to evaluate effects chitosan and duck fat-based emulsion coatings on characteristics stability during refrigerated storage. coated samples were as follows: control (non-coated), DFC0 (coated with fat), DFC0.5 fat 0.5% chitosan), DFC1 1% DFC2 2% SOC2 soybean oil chitosan)....
We report a novel protein immobilization matrix for fully integrated microfluidic Western blotting (WB). The electrostatic gel (EIG) enables of all proteins sized using cetyl trimethylammonium bromide polyacrylamide electrophoresis (CTAB-PAGE), subsequent electrophoretic probing with detection affinity reagents (e.g., labeled antibodies). "pan-analyte" capture strategy introduced here uses grafted concentrated point charges (zwitterionic macromolecules), in contrast to existing WB strategies...
Abstract Human induced pluripotent stem cells (iPSCs) hold great promise for personalized medicine, as they can be differentiated into specific cell types, especially mesenchymal (MSCs). Therefore, our study sought to assess the feasibility of deriving MSCs from teratomas generated human iPSCs. Teratomas serve a model mimic multilineage development, thus enriching somatic progenitors and cells. Here, we discovered small, condensed mass within iPSC‐generated teratomas. Afterward, successfully...
A subset of ventral spinal cord precursors, known as pMN precursor cells, initially generate motor neurons and then oligodendrocyte progenitor cells (OPCs), which migrate differentiate myelinating oligodendrocytes in the developing neural tube. The switch between neuron production by precursors is an important step building a functional nervous system. However, precise mechanism that orchestrates sequential generation within common population still unclear. current study demonstrates Indian...
As the main symptom of Alzheimer’s disease-related dementia is memory loss, patient compliance for donepezil hydrochloride (donepezil), administered as once-daily oral formulations, poor. Thus, we aimed to design poly(lactic-co-glycolic acid) (PLGA) microspheres (MS) with alginate-coated large pores an injectable depot exhibiting sustained release over 2–3 weeks. The PLGA MS could provide space loading drugs high capacity, and thereby sufficient amounts were considered be delivered minimal...
Automated measurement of the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) can support clinical decision making. Based on a deep learning algorithm, we developed an automated ASPECTS scoring system (Heuron ASPECTS) and validated its performance in prespecified trial.
Adenosine (AD), which is used for treating wrinkles, exhibits poor skin permeation. The aim of the present study was to develop a cross-linked silicone-based cellulose elastomer as an elastic artificial treatment biocompatible lipid-based nano-carrier enhancing permeation AD, and formulation consisting carrier incorporated in skin. AD-loaded solid lipid nanoparticles (SLNs) were prepared using double-emulsion method. Particle characteristics mechanical properties SLNs skin, respectively,...
This paper reports a new method to make crystal defects on the surface of multi-walled carbon nanotubes (MWCNTs) using cobalt oxide as oxidant for breaking surface. The air oxidation (CoO) deposited MWCNTs created various kinds their Transmission Electron Micrograph (TEM) images showed clear such broken lines and asymmetric wall after oxidation. X-ray powder diffraction (XRD) data that CoO changed into Co3O4 After removing from by acid, defective were obtained trace where had existed....
A rapid method for the synthesis of carbon-11 radiolabeled indole was developed using a sub-nanomolar quantity no-carrier-added [(11)C]cyanide as radio-precursor. Based upon reported 2-(2-nitrophenyl)acetonitrile (), highly reactive substrate 2-nitrobenzyl bromide () evaluated nucleophilic [(11)C]cyanation. Additionally, related reaction conditions were explored with goal obtaining 2-(2-nitrophenyl)-[1-(11)C]acetonitrile while inhibiting its conversion to...
Itraconazole (ITZ) is an anti-fungal agent generally used to treat cutaneous mycoses. For efficient delivery of ITZ the skin tissues, oil-in-water (O/W) cream formulation was developed. The O/W base designed based on solubility measurement in various excipients. A physical mixture and also prepared as a control evaluate effects solubilized state vitro deposition behavior ITZ. Polarized light microscopy differential scanning calorimetry demonstrated that fully formulation. exhibited...