To investigate the association of vessel tortuosity with severity diabetic retinopathy (DR) using optical coherence tomography angiography.We retrospectively analyzed 30 healthy eyes and 121 subjects no DR, mild nonproliferative DR (NPDR), moderate to severe NPDR proliferative (PDR). Binarized images were used quantify tortuosity, density, foveal avascular zone (FAZ) area, FAZ acircularity. The vessels divided vertically as superficial retinal layer deep layer, horizontally circular areas 3...

Purpose: To investigate the associations between soluble CD14 (sCD14), a cytokine released by microglia and macrophages, hyperreflective foci (HF) various characteristics of spectral-domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME). Methods: Sixty-nine eyes from 51 patients with DME 28 control subjects were studied. sCD14 levels aqueous humor (AH) measured using ELISA before bevacizumab injection (IVB), visual acuity, number HF, retinal volume, pattern assessed....

Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, are overexpressed in cells, limiting specificity and inducing severe side effects. To overcome these limitations, we constructed self-assembling targeting with intracellular oligomerization system. Intracellular aryl-dithiol-containing peptide occurred only inside the mitochondria of due to selective localization...

Age-related macular degeneration (AMD) is one of the leading causes blindness in elderly individuals. However, currently used intravitreal injections anti-vascular endothelial growth factor are invasive, and repetitive also accompanied by a risk intraocular infection. The pathogenic mechanism AMD still not completely understood, but multifactorial that combines genetic predisposition environmental factors, including cellular senescence, has been suggested. Cellular senescence refers to...

In Brief Purpose: To investigate the association between baseline retinal microstructures including hyperreflective foci (HF), shown by spectral domain optical coherence tomography, and visual outcome recurrence after laser photocoagulation for central serous chorioretinopathy. Methods: We retrospectively reviewed 62 eyes from medical records of chorioretinopathy patients. At initial visit, acuity, presence photoreceptor granulation, subretinal fluid thickness, choroidal thickness at macula,...

Processes that regulate size and patterning along an axis must be highly integrated to generate robust shapes; relative changes in these processes underlie both congenital disease evolutionary change. Fin length mutants zebrafish have provided considerable insight into the pathways regulating fin size, yet signals underlying remained less clear. The bony rays of fins possess distinct proximodistal axis, reflected location ray bifurcations lengths segments, which show progressive shortening...

Purpose: Predicting long-term anatomical responses in neovascular age-related macular degeneration (nAMD) patients is critical for patient-specific management. This study validates a generative deep learning (DL) model to predict 12-month posttreatment optical coherence tomography (OCT) images and evaluates the impact of incorporating clinical data on predictive performance. Methods: A total 533 eyes from 513 treatment-naïve nAMD were analyzed. conditional adversarial network (cGAN) served...

Introduction: The link between arterial stiffness, measured by estimated pulse wave velocity (ePWV), and outcomes following endovascular treatment (EVT) is unclear. Hypothesis: This study aimed to determine whether ePWV predicts post-EVT outcome in patients with acute ischemic stroke. Methods: was a secondary analysis of the OPTIMAL-BP trial, which enrolled 302 EVT from 19 stroke centers Korea June 18, 2020 November 28, 2022. calculated using regression equation based on age mean blood...

Purpose: To evaluate and compare changes in choroidal vascular stromal areas patients with three major pachychoroid diseases for better insight into the pathophysiology of these diseases. Methods: Eighty-six eyes 86 (50 men 36 women; mean age, 49.1 years) were evaluated, including 21 chronic central serous chorioretinopathy (CSC), 14 pigment epitheliopathy (PPE), 19 neovasculopathy (PNV), myopic neovascularization (mCNV), 18 controls. Multimodal retinal imaging, enhanced-depth imaging...

In Brief Purpose: To investigate the correlation between hyperreflective foci (HF) on spectral domain optical coherence tomography at baseline and visual outcomes after intravitreal anti-vascular endothelial growth factor injection in neovascular age-related macular degeneration (nAMD) polypoidal choroidal vasculopathy (PCV). Methods: The authors retrospectively reviewed medical records of 44 patients with nAMD PCV. number HF was counted according to location tomography: neurosensory retinal...

This study aimed to investigate the association between ambient air pollutants and cataracts in general population aged 50 years or older using data from Korean National Insurance Service—National Sample Cohort. Cataract patients were defined as those diagnosed by a physician having undergone cataract surgery. After matching average concentrations of PM2.5, PM10, NO2, CO, SO2, O3 residential areas, quartile level incidence was analyzed multivariate Cox-proportional hazard risk model. Among...

Purpose: To develop a deep learning model to generate posttreatment optical coherence tomography (OCT) images of neovascular age-related macular degeneration. Methods: Two hundred ninety-eight patients with degeneration were included. The conditional generative adversarial network was trained using 15,183 augmented paired OCT B-scan obtained from 723 scans 241 at baseline and 1 month after 3 loading doses an anti–vascular endothelial growth factor treatment. also fluorescein angiography (FA)...

Abstract Background Periodontal disease can activate an immune process linked to systemic diseases, including atrial fibrillation. However, the relationship between periodontal and fibrillation remains unclear. Aim This study aimed investigate whether changes in status are associated with risk of Methods Using National Health Insurance Database Korea, participants who underwent first oral health examination 2003 a second 2005–2006 without history were included. Participants grouped according...

Purpose: To investigate the association of three-dimensionally quantified lesions with best-corrected visual acuity (BCVA) in typical neovascular age-related macular degeneration (nAMD). Methods: We retrospectively analyzed 65 eyes 61 nAMD patients. Lesions at baseline and month 12 were manually delineated optical coherence tomography. The volume intraretinal fluid (IRF), subretinal (SRF), hyperreflective material (SHRM), pigment epithelial detachment (PED) measured. In addition, areas...

The risk of dry and wet age-related macular degeneration (AMD) based on fasting glucose levels disease duration type 2 diabetes was investigated.Using a health insurance claims database the results examinations in South Korea, we conducted retrospective, population-based cohort study 2,103,604 adults ≥ 45 years age who were AMD-free checkups 2009 observed from January 1, 2011, to December 31, 2018. Glycemic status classified into five groups: normal, impaired glucose, new-onset (fasting...

To evaluate the long-term effect of latanoprost on central corneal thickness (CCT) in patients with normal-tension glaucoma (NTG).This retrospective study included 41 eyes NTG and 40 individuals suspect (controls). Newly diagnosed no previous treatment were administered 0.005% monotherapy once a day. CCTs measured by ultrasound pachymetry before followed up annually for 5 years.A significant reduction mean CCT was observed group [542.3±36.2 μm vs. 533.7±32.9 (n=41), P<0.001], but not control...

Abstract Cellular senescence of the retinal pigment epithelium (RPE) is thought to play an important role in vision-threatening degenerative diseases, such as age-related macular degeneration (AMD). However, single-cell RNA profiles control RPE tissue and exhibiting cellular are not well known. We have analyzed transcriptomes mice with low-dose doxorubicin (Dox)-induced (Dox-RPE). Our results identified 4 main subpopulations that exhibit heterogeneous biological activities roles ATP...

To investigate the prognostic factors of visual and anatomic outcomes in patients with diabetic macular edema (DME) treated intravitreal injection dexamethasone implant.We retrospectively studied 32 eyes 31 DME for best-corrected acuity (BCVA), central thickness, height width both intraretinal fluid (IRF) subretinal fluid. Logistic regression analysis was used to examine correlations between baseline characteristics at 3 6 months.Baseline predictor BCVA ≥20 / 40 month short IRF (p = 0.02),...

Proteinuria is associated with cardiovascular disease. However, the relationship between changes in proteinuria status and hypertension remains unclear. This study aimed to explore association risk of developing data from Korean National Health Insurance Database. We included participants without prior history who underwent their first health examination 2003-2004 a second 2005-2006. Based on during these two examinations, were classified into four groups: proteinuria-free,...