A5068781042- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Gut microbiota and health
- Renal and Vascular Pathologies
- Clostridium difficile and Clostridium perfringens research
- Hepatitis C virus research
- Optical Imaging and Spectroscopy Techniques
- Blood Pressure and Hypertension Studies
- Stroke Rehabilitation and Recovery
- Hepatitis B Virus Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Sepsis Diagnosis and Treatment
- Aortic Thrombus and Embolism
- Occupational Health and Safety Research
- NF-κB Signaling Pathways
- Nail Diseases and Treatments
- Chinese history and philosophy
- Dermatological and COVID-19 studies
- Dietary Effects on Health
- Diet and metabolism studies
Yonsei University
2015-2025
Severance Hospital
2015-2025
Changsha Central Hospital
2024
University of South China
2024
Yonsei University Health System
2020-2021
Many endogenous and exogenous factors are known to cause enlarged pilosebaceous pores. Such include sex, genetic predisposition, ageing, chronic ultraviolet light exposure, comedogenic xenobiotics, acne seborrhoea. This study was an attempt determine the related pores.To assess relationship of sebum output, age, hormonal severity with pore size.A prospective, randomized, controlled designed. A total 60 volunteers, 30 males females, were recruited for this study. Magnified images pores taken...
Abstract Background Many studies have revealed the real-world effectiveness and tolerability of Dolutegravir/Lamivudine (DTG/3TC). However, most were conducted in Western countries, data from Asian countries are still lacking; particular, results long-term use not been reported countries. As DTG/3TC has introduced is becoming increasingly widespread Asia, it necessary to investigate maintenance rate, reasons for discontinuation, effectiveness, metabolic parameter changes. Methods We...
Introduction: The link between arterial stiffness, measured by estimated pulse wave velocity (ePWV), and outcomes following endovascular treatment (EVT) is unclear. Hypothesis: This study aimed to determine whether ePWV predicts post-EVT outcome in patients with acute ischemic stroke. Methods: was a secondary analysis of the OPTIMAL-BP trial, which enrolled 302 EVT from 19 stroke centers Korea June 18, 2020 November 28, 2022. calculated using regression equation based on age mean blood...
BACKGROUND The link between arterial stiffness, measured by estimated pulse wave velocity (ePWV), and outcomes following endovascular thrombectomy (EVT) has not been tested. This study aimed to determine whether ePWV predicts post‐EVT outcome in patients with acute ischemic stroke. METHODS was a secondary analysis of the OPTIMAL‐BP (Outcome Patients Treated With Intraarterial Thrombectomy–Optimal Blood Pressure Control) trial, which enrolled 302 EVT from 19 stroke centers South Korea June...
Abstract This study aimed to investigate the association between muscle mass deficit and initial severity of ischemic stroke. The impact on discharge outcome was also evaluated. retrospective included 660 patients with acute stroke who underwent bioelectrical impedance analyses. We compared National Institute Health Stroke Scale (NIHSS) score, occurrence moderate (NIHSSS ≥ 5) at admission, unfavorable functional (modified Rankin score 2) without using Poisson logistic regression mean age...
Abstract The prognosis of patients with embolic stroke undetermined source (ESUS) may vary according to the underlying cause. Therefore, we aimed divide ESUS into subtypes and assess long-term outcomes. Consecutive acute ischemic who underwent a comprehensive workup, including transesophageal echocardiography prolonged electrocardiography monitoring, were enrolled. We classified minor cardioembolic (CE) ESUS, arteriogenic two or more causes no cause ESUS. Arteriogenic was sub-classified...
Solid organ transplant (SOT) recipients are at significant risk of hepatitis B (HB) virus (HBV) reactivation (HBVr). Despite the clinical significance HBVr after solid transplantation, data on factors for and vaccine effectiveness in SOT with resolved HBV infection limited. This study evaluated seroconversion rates vaccination recipients. Patients who had undergone transplantation those a were identified. We matched patients experienced post-transplantation did not. also explored...
Vascular aging phenotype may be useful in predicting stroke prognosis. In the present study, relationship between vascular phenotypes and outcomes after acute ischemic was investigated. The study included consecutive patients with who had brachial-ankle pulse wave velocity (baPWV) measured to assess phenotype. 2.5th 97.5th percentile age-specific baPWVs were used as cutoffs define supernormal (SUPERNOVA) early (EVA), respectively, remainder considered normal (NVA). A total of 2738 enrolled...
The NOD2 signaling pathway, which plays an important role in the mechanisms of inflammatory bowel disease (IBD) development, has been closely associated with ubiquitination. It was revealed this study that receptor activation could obviously affect expression 19 ubiquitination-related genes, N4BP3 being most prominently expressed and upregulated. In addition, knockdown found to reduce mRNA levels MDP-induced factors, while overexpression elevated their as well phospho-ERK1/2, phospho-JNK,...
Introduction: Gut microbiota dysbiosis is associated with susceptibility to sepsis and poor outcomes. However, changes the intestinal during their value as biomarkers are unclear. In this study, we compared of patients healthy controls. Methods: Stool was collected from (subdivided according mortality) Microbiome diversity composition were analyzed by 16S rRNA gene pyrosequencing. The α-diversity microbiome determined using operational taxonomic unit counts Chao1, Shannon, ACE indices....
Atrial fibrillation (AF) shares several risk factors with atherosclerosis. We investigated the association between total carotid plaque number (TPN) and long-term prognosis in ischemic stroke patients AF. A of 392 AF who underwent ultrasonography were enrolled. TPN was assessed using B-mode ultrasound. The categorized into two groups according to best cutoff values for (TPN ≤ 4 vs. ≥ 5). major adverse cardiovascular events (MACE) mortality a Cox hazard model. After mean follow-up 2.42 years,...
Background: This study investigated the association of high ankle-brachial index difference (ABID) and systolic inter-ankle blood pressure (IAND) with short- long-term outcomes in acute ischemic stroke patients without peripheral artery disease (PAD). Methods: Consecutive who underwent (ABI) measurement were enrolled. ABID was calculated as |right ABI-left ABI|. IAND inter-arm (IAD) – left pressure|. Poor functional outcome defined modified Rankin Scale score ≥3 at 3 months. Major adverse...
Background Etiology is unknown in approximately one-quarter of stroke patients after evaluation, which termed cryptogenic (CS). The prognosis CS largely undetermined. We created a novel index from transcranial Doppler parameters including mean flow velocity (MV) and pulsatility (PI) investigated whether the calculation asymmetry parameter can predict functional outcomes patients. Methods made middle cerebral artery (MCA) (%) as parameter, was calculated 100 X (MCA MV + MCA PI 10) / MV–MCA...
The occurrence of subclavian steal syndrome is possible in patients with either severe stenosis or occlusion the left proximal brachiocephalic arteries. Limited and insufficient blood flow vessel a lesion induces supply from opposite side via any connected vessels, which called phenomenon. duplex sonography useful for detecting this Some who experience phenomenon complain vertebrobasilar insufficiency, such as headache numbness weakness arm, so on. Subclavian means accompanied by these...
Background: The association between arterial stiffness and outcome after endovascular treatment (EVT) is unknown. This study investigated whether predicts post-EVT in patients with acute ischemic stroke. Methods: retrospective observational cohort included consecutive treated EVT for stroke from June 2020 to November 2022. Arterial was assessed by brachial–ankle pulse wave velocity. Poor functional defined as a modified Rankin Scale score ≥3 at 3 months. Results: mean age of this 71.9 ± 11.8...
Introduction: Cardioembolic stroke (CE) has poor outcomes and high recurrence rates. A low ankle-brachial index (ABI <0.9) is associated with atrial fibrillation (AF) outcomes. We investigated whether a ABI recurrence, major adverse cardiovascular events (MACE), mortality in patients CE this association affected by AF. Methods: enrolled who underwent measurements during hospitalization. Recurrent was defined based on newly developed neurologic symptoms relevant lesions 7 days after the...
<title>Abstract</title> Fecal microbiota transplantation (FMT) has proven effective in decolonizing carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant Enterococci (VRE). However, its efficacy varies among patients, frequent implementation poses challenges. Through microbiome analysis of fecal samples from both FMT responders non-responders, we identified a consortium four gut commensal species, termed BM111. In an antibiotic-pretreated mouse infection model, BM111...
ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease caused by the SFTS virus (SFTSV). CP-COV03 novel antiviral candidate that significantly enhanced bioavailability of niclosamide through inorganic-based drug delivery technology. The active pharmaceutical ingredient CP-COV03, niclosamide, has been previously shown to possess broad-spectrum activity against over 30 different viruses in vitro tests. aim this study confirm SFTSV an model. Vero cells...
This study examined whether the difference in middle cerebral artery (MCA) velocities can predict prognosis of stroke and prognostic impact differs among subtypes. Transient ischemic attack (TIA) or acute patients, who underwent a routine evaluation transcranial Doppler (TCD), were included this study. The MCA asymmetry index was calculated using relative percentage mean flow velocity (MFV) between left right MCA: (|RMCA MFV-LMCA MFV|/mean MFV)×100. subtypes determined TOAST classification....