Kun Chen

ORCID: 0000-0002-5228-0521
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About
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Research Areas
  • Sinusitis and nasal conditions
  • Allergic Rhinitis and Sensitization
  • Reconstructive Facial Surgery Techniques
  • Ultrasound Imaging and Elastography
  • AI in cancer detection
  • Radiomics and Machine Learning in Medical Imaging
  • Asthma and respiratory diseases
  • Ear Surgery and Otitis Media
  • Advanced Measurement and Detection Methods
  • Inflammasome and immune disorders
  • Endoplasmic Reticulum Stress and Disease
  • Indoor and Outdoor Localization Technologies
  • NF-κB Signaling Pathways
  • Structural Load-Bearing Analysis
  • Power Systems and Technologies
  • Millimeter-Wave Propagation and Modeling
  • Engineering Applied Research
  • Advanced Measurement and Metrology Techniques
  • Precipitation Measurement and Analysis
  • Power Systems and Renewable Energy
  • Ferroptosis and cancer prognosis
  • Infectious Diseases and Mycology
  • interferon and immune responses
  • Nasal Surgery and Airway Studies
  • Head and Neck Surgical Oncology

Changsha Central Hospital
2024

University of South China
2024

Guangzhou University of Chinese Medicine
2024

Zhejiang University
2024

Shanghai Jiao Tong University
2014-2023

Intelligent Health (United Kingdom)
2022

XinHua Hospital
2017-2021

Shanghai Sixth People's Hospital
2018

Shanghai Ninth People's Hospital
2014-2017

<h3>Importance</h3> Empty nose syndrome (ENS) is an iatrogenic disorder, which severely affects the normal nasal breathing function. People affected by ENS may experience decreased productivity and lifestyle disruption. The 20-Item Sino-Nasal Outcome Test (SNOT-20) a validated quality-of-life measurement can be used to compare before after intervention outcomes. <h3>Objectives</h3> To evaluate effectiveness of Medpor implant (Porex Surgical Inc) improve disease-specific quality life in...

10.1001/jamaoto.2014.84 article EN JAMA Otolaryngology–Head & Neck Surgery 2014-03-13

Necroptosis is an inflammatory cell death associated with a variety of chronic diseases. Chronic rhinosinusitis nasal polyps (CRSwNP) disease accompanied by eosinophil and neutrophil infiltration. The role necroptosis in the pathogenesis CRSwNP remains elusive.Cell death, including apoptosis, pyroptosis control sinonasal mucosa CRSwNP, were analyzed immunoblotting, immunohistochemistry (IHC) immunofluorescence (IF) staining for cleaved caspase 3, gasdermin D p-MLKL, respectively....

10.2147/jir.s322875 article EN cc-by-nc Journal of Inflammation Research 2021-08-01

10.1007/s00170-018-03212-w article EN The International Journal of Advanced Manufacturing Technology 2019-01-05

Purpose We aimed to compare the diagnostic performance and interobserver variability in breast tumor classification with or without aid of an innovative dual-mode artificial intelligence (AI) architecture, which can automatically integrate information from ultrasonography (US) shear-wave elastography (SWE). Methods Diagnostic assessment was performed a test subset, containing 599 images (from September 2018 February 2019) 91 patients including 64 benign 27 malignant tumors. Six radiologists...

10.5152/dir.2021.20018 article EN Diagnostic and Interventional Radiology 2021-04-19

The NOD2 signaling pathway, which plays an important role in the mechanisms of inflammatory bowel disease (IBD) development, has been closely associated with ubiquitination. It was revealed this study that receptor activation could obviously affect expression 19 ubiquitination-related genes, N4BP3 being most prominently expressed and upregulated. In addition, knockdown found to reduce mRNA levels MDP-induced factors, while overexpression elevated their as well phospho-ERK1/2, phospho-JNK,...

10.1038/s41420-024-02213-x article EN cc-by Cell Death Discovery 2024-10-17

We conducted a retrospective study to evaluate the relationship between external auditory canal (EAC) anomaly, temporal bone abnormality, and hearing levels using objective scoring systems in Chinese patients with microtia. The population consisted of 106 ears 94 (67 male 27 female) aged 5 45 years (mean: 12.6) EAC abnormalities were classified into 4 types according Schuknecht's criteria: type A, B, C, D. Developmental anomalies evaluated by Jahrsdoerfer computed tomography (CT) system...

10.1177/014556131709600620 article EN Ear Nose & Throat Journal 2017-06-01

An accurate recognition of a dimensional variation pattern is very important for producing high-quality body-in-white (BIW). The wide application optical coordination measurement machines (OCMM) in vehicle factory provided massive online data the recognition. However, serially correlated or autocorrelated and 100% generated from OCMM challenge traditional statistical process control (SPC) technology common approaches. This paper presents novel deep-learning method, long short-term memory...

10.1109/access.2019.2918784 article EN cc-by-nc-nd IEEE Access 2019-01-01

Background:The cysteinyl leukotrienes (cysLTs) are proinflammatory lipid mediators that act on the type 1 cysLT receptor (CysLT1R) in pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP).GPR17, a G protein-coupled orphan homology to receptors, has been proposed as damage sensor during inflammation.However, expression and correlation GPR17 CysLT1R eosinophilic CRSwNP (ECRS) non-eosinophilic (non-ECRS) have not well investigated.Objective: To evaluate its 2 subsets.Methods: Polyp...

10.12932/ap-030417-0063 article EN Asian Pacific Journal of Allergy and Immunology 2017-01-01

PURPOSE Serum/glucocorticoid-regulated kinase 1 (SGK1) has recently emerged as a critical regulator of inflammatory diseases. In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS). METHODS Immunohistochemistry, western blotting, Bio-Plex assay, enzyme-linked immunosorbent assays, quantitative real-time polymerase chain reaction were performed to assess protein gene levels. The mRNA levels interleukin-6 (IL-6) extracted from CRS database...

10.4168/aair.2021.13.5.776 article EN Allergy Asthma and Immunology Research 2021-01-01

Abstract The morphological structure and dynamic characteristics of power distribution systems are rapidly evolving due to the widespread application distributed renewable energy rapid advancement electronics technology. stability analysis these complex new depends on electromagnetic transient (EMT) simulation. However, intellectual property rights protection by manufacturers leads many network devices that can only use black-box models with missing parameters, which challenges This reduces...

10.1088/1742-6596/2826/1/012029 article EN Journal of Physics Conference Series 2024-08-01

10.1007/s12204-015-1662-3 article EN Journal of Shanghai Jiaotong University (Science) 2015-10-01

Abstract Interleukin 4-induced gene 1 (IL4I1) is associated with tumor immune invasion; however, its involvement in head and neck squamous cell carcinoma (HNSCC) not well documented. Publicly accessible databases our tissue mRNA sequencing result were used to evaluate IL4I1 expression HNSCC. The Wilcoxon rank-sum test was performed examine the relationship between clinicopathological characteristics expression. Signaling pathways identified via set enrichment analysis (GSEA). CIBERSORT...

10.21203/rs.3.rs-2639366/v1 preprint EN cc-by Research Square (Research Square) 2023-03-20

Abstract The combustion chamber of automobile engine is a place where gasoline burned to provide power for driving and its size has great influence on performance. However, because the irregularity chamber, it difficult measure accurately efficiently. principle Helmholtz resonance reveals functional relationship between volume resonant frequency closed cavity. Having used principle, equipment measuring efficiently been built. conditions under which cavity stimulated produce are explored,...

10.1115/imece2019-10822 article EN Volume 2B: Advanced Manufacturing 2019-11-11

10.1007/s12204-022-2484-8 article EN Journal of Shanghai Jiaotong University (Science) 2022-08-19
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