A5048884066- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer therapeutics and mechanisms
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Sarcoma Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
Wenzhou Medical University
2023-2024
Beijing Chao-Yang Hospital
2022-2024
Capital Medical University
2022-2024
Nanjing Drum Tower Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Westlake University
2023
Chinese Academy of Meteorological Sciences
2023
Zhuhai People's Hospital
2020-2023
Central South University
2023
Capital University
2023
Androgen deprivation is currently a standard-of-care, first-line therapy for prostate cancer in the United States. Although this regimen effectively regresses androgen-dependent disease, relapse often occurs an androgen-independent manner and associated with poor prognosis. Such castration-resistant represents major clinical challenge, mechanisms underlying castration resistance are not fully understood. Epithelial-mesenchymal transition (EMT) key developmental process has also been...
The basal-like subtype of breast cancer has an aggressive clinical behavior compared to that the luminal subtype. We identified microRNAs (miRNAs) miR-221 and miR-222 (miR-221/222) as subtype-specific miRNAs showed expression miR-221/222 decreased epithelial-specific genes increased mesenchymal-specific genes, cell migration invasion in a manner characteristic epithelial-to-mesenchymal transition (EMT). transcription factor FOSL1 (also known Fra-1), which is found cancers but not subtype,...
BCL-2 family proteins dictate survival of human multiple myeloma cells, making them attractive drug targets. Indeed, cells are sensitive to antagonists that selectively target prosurvival such as BCL-2/BCL-XL (ABT-737 and ABT-263/navitoclax) or only (ABT-199/GDC-0199/venetoclax). Resistance these three drugs is mediated by expression MCL-1. However, given the selectivity profile venetoclax it unclear whether coexpression BCL-XL also affects antitumor responses in myeloma. In cell lines (n =...
Abstract Selective kinase inhibitors have emerged as an important class of cancer therapeutics, and several such drugs are now routinely used to treat advanced-stage disease. However, their clinical benefit is typically short-lived because the relatively rapid acquisition drug resistance following treatment response. Accumulating preclinical data point a role for heterogeneous response within subpopulation tumor cells that intrinsically drug-resistant, stem cells. We previously described...
Although well studied in vitro , the vivo functions of G-quadruplexes (G4-DNA and G4-RNA) are only beginning to be defined. Recent studies have demonstrated enrichment for sequences with intramolecular G-quadruplex forming potential (QFP) transcriptional promoters humans, chickens bacteria. Here we survey yeast genome QFP similarly find strong these upstream promoter regions, as weaker but significant open reading frames (ORFs). Further, four findings consistent roles regulation. First, is...
The epithelial-to-mesenchymal transition (EMT) is a highly conserved physiological program involved in development and tissue repair; however, its aberrant activation has been implicated accelerating the progression of variety cancers. In breast cancer, microRNAs (miRNAs) miR-221 miR-222 (miR-221/222) are differentially expressed clinically more aggressive basal-like subtype compared to luminal cancer upregulation miR-221/222 induces EMT by targeting 3' untranslated region (3'UTR) GATA...
We comprehensively analyzed the global burdens and trends in incidence mortality of tracheal, bronchus, lung (TBL) cancer among subgroups distinctive ages genders.We retrieved rates 2020 from GLOBOCAN database 185 countries. The age-standardized (ASRs) were mostly obtained Cancer Incidence Five Continents World Health Organization database, respectively. joinpoint regression analysis has been conducted to evaluate average annual percentage change recent years.Trends decreasing men most...
To examine the potential of combining Bcl-2 family inhibitors with chemotherapy in ovarian cancer, we evaluated a panel 27 cancer cell lines for response to combination navitoclax (formerly ABT-263) and paclitaxel or gemcitabine. The majority exhibited greater than additive either combination, as determined by Bliss independence model, more 50% strong synergy navitoclax/paclitaxel combination. identify biomarkers tumors likely respond this protein levels intrinsic apoptosis pathway...
Invadopodia are actin-rich membrane protrusions formed by tumor cells that degrade the extracellular matrix for invasion. formation involves driven Arp2/3-mediated actin polymerization and secretion of metalloproteinases (MMPs) at focal degrading sites. The exocyst mediates tethering post-Golgi secretory vesicles plasma exocytosis has recently been implicated in regulating dynamics during cell migration. Here, we report plays a pivotal role invadopodial activity. With RNAi knockdown...
To explore the potential of navitoclax in combination with taxane-based chemotherapy treatment non-small cell lung cancer (NSCLC) by defining mechanism synergy and identifying correlative biomarkers.We treated a panel NSCLC lines dose matrix paclitaxel (formerly ABT-263), an inhibitor Bcl-2, Bcl-x(L), Bcl-w (1), evaluated synergy. We next used time-lapse microscopy to Finally, we developed immunohistochemical assay assessed prevalence Bcl-x(L) tumor tissues.All exhibit greater than additive...
Matrix metalloproteinase-9 (MMP-9), whose expression is frequently dysregulated in cancer, promotes tumor growth, invasion, and metastasis by multiple mechanisms, including extracellular matrix remodeling growth-factor cytokine activation. We developed a monoclonal antibody against murine MMP-9, which we found decreased growth of established primary tumors an orthotopic model HER2-driven breast cancer (HC11-NeuT) immunocompetent mice. RNA sequencing (RNAseq) profiling NeuT additional mouse...
Abstract In mammals, ovarian function is dependent on the primordial follicle pool and rate of activation determines a female's reproductive lifespan. Ovarian ageing characterised by chronic low‐grade inflammation with accelerated depletion follicles deterioration oocyte quality. Macrophages (Mφs) play critical roles in multiple aspects functions; however, it remains unclear whether Mφs modulate what their role ageing. Here, using super‐ or naturally ovulated mouse models, we demonstrated...
Abstract Iron deficiencies are the most common nonenteric syndromes observed in patients with inflammatory bowel disease, but little is known about their impacts on immune tolerance. Here we show that homeostasis of regulatory T cells intestine was dependent high cellular iron levels, which were fostered by pentanoate, a short-chain fatty acid produced intestinal microbiota. Treg caused depletion Transferrin receptor 1, major transporter, result abrogation and lethal autoimmune disease. 1...
Oesophageal cancer is a prevalent and deadly around the world. We aimed to present comprehensive analysis of global geographic patterns temporal trends in mortality incidence oesophageal cancer. The data 2020 were obtained from GLOBOCAN database. Based on World Health Organization (WHO) database Cancer Incidence Five Continents (CI5), we also retrieved age-standardized rates (ASRs) average annual percentage changes (AAPCs) calculated using joinpoint regression analysis. Globally, 0.54...
Neoadjuvant immunochemotherapy (nICT) has dramatically changed the treatment landscape of operable esophageal squamous cell carcinoma (ESCC), but factors influencing tumor response to nICT are not well understood. Here, using single-cell RNA sequencing paired with T receptor sequencing, we profile tissues from ESCC patients accepting and characterize microenvironment context. CXCL13+CD8+ Tex cells, a subset exhausted CD8+ revealed highly infiltrate in pre-treatment tumors show prominent...
A 56-day experiment was carried out to investigate the effects of dietary vitamin C and E on growth, antioxidant status digestive enzyme activities discus fish (Symphysodon haraldi; initial body weight: 7.96 ± 0.61 g length: 5.45 0.65 cm). Animals were fed with 13 different diets including one control diet 12 treatment containing four levels (magnesium-L-ascorbyl-2-phosphate; 40, 80, 120 160 mg/kg) crossed three (DL-α-tocopheryl acetate; 80 mg/kg). The results showed that additional (40 (80...
Long non‐coding RNA s (lnc s) are transcripts longer than 200 nt that involved in tumorigenesis and play a key role cancer progression. To determine whether lnc acute myeloid leukemia ( AML ), we analyzed the expression profile of mRNA . Five pairs patients iron deficiency anemia IDA ) controls were screened by microarray. Through coexpression analysis, differently expressed divided into modules, functionally annotated. We further clinical significance crucial from modules public data....