A5074968578- Genetic Neurodegenerative Diseases
- Cancer Immunotherapy and Biomarkers
- Hereditary Neurological Disorders
- Immunotherapy and Immune Responses
- Neurological diseases and metabolism
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Meningioma and schwannoma management
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Global Cancer Incidence and Screening
- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cardiovascular Health and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Alzheimer's disease research and treatments
- Diet, Metabolism, and Disease
- Head and Neck Surgical Oncology
- Cellular transport and secretion
Central South University
2023-2024
Sichuan Cancer Hospital
2024
University of Electronic Science and Technology of China
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Third Xiangya Hospital
2023-2024
Peking Union Medical College Hospital
2024
We comprehensively analyzed the global burdens and trends in incidence mortality of tracheal, bronchus, lung (TBL) cancer among subgroups distinctive ages genders.We retrieved rates 2020 from GLOBOCAN database 185 countries. The age-standardized (ASRs) were mostly obtained Cancer Incidence Five Continents World Health Organization database, respectively. joinpoint regression analysis has been conducted to evaluate average annual percentage change recent years.Trends decreasing men most...
Abstract Backgroud Recent studies have indicated that programmed cell death‐ligand 1 (PD‐L1) and cluster of differentiation 47 (CD47) play an essential role in tumor immune evasion may serve as potential targets for combined immunotherapy. The aim our study was to evaluate the PD‐L1/CD47 expression status lung squamous carcinoma (LUSC) adenocarcinoma (LUAD), explore its survival impact relevance with microenvironment. Methods specimens from 190 LUSC 240 LUAD patients who underwent...
We aimed to explore the associations of baseline and cumulative cardiovascular health with nonalcoholic fatty liver disease (NAFLD) development regression using new Life's Essential 8 score.
Abstract Backgrounds The characteristics of programmed cell death protein-1 (PD-L1) expression, tumor-infiltrating lymphocytes (TILs), and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) patients are closely related to immunotherapy, there differences between Asians Caucasians. Methods Acquire the transcriptome data Cancer Genome Atlas Chinese LUAD patients. R software was used analyze differential expression genes, prognosis, gene function. Use CIBERSORT for TIL-related analysis...
Abstract Objective To explore the risk factors for disease progression after initial treatment of type B thymomas using a predictive nomogram model. Methods A single-center retrospective study patients with thymoma was performed. The Cox proportional hazard model used univariate and multivariate analyses. Variables statistical clinical significance in regression were integrated into to establish progression. Results total 353 cases retrieved between January 2012 December 2021. median...
Abstract Background and Aims This study aimed to report nine Charcot–Marie–Tooth disease (CMT) families with six novel IGHMBP2 mutations in our CMT2 cohort summarize the genetic clinical features of all AR‐CMT2S patients reported worldwide. Methods General information, neurophysiological data 275 axonal CMT were collected. Genetic screening was performed by inherited peripheral neuropathy related genes panel or whole exome sequencing. The published papers reporting from 2014 2023 searched...
Introduction To evaluate the preoperative health-related quality of life (HRQoL) and influencing factors HRQoL in patients undergoing thyroidectomy based on patient-reported outcomes. Materials methods Patients who were diagnosed treated Sichuan Cancer Hospital from February 2022 to December scheduled undergo included. Each participant completed basic information questionnaire outcome assessment scales before surgery. was assessed using European Organization for Research Treatment Quality...
Abstract Background Recent studies indicated that T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) cluster of differentiation 47 (CD47) have emerged as new potential immunotherapy targets. However, the roles TIGIT CD47 in lung squamous carcinoma (LUSC) not been fully illustrated. Methods The specimens clinicopathological information from 190 LUSC patients who underwent surgeries our center were retrospectively collected. Immunohistochemical staining for was conducted....
Abstract Background and Aims Biallelic variants in the sorbitol dehydrogenase ( SORD ) gene have been identified as genetic cause of autosomal recessive (AR) peripheral neuropathy (PN) manifesting Charcot–Marie–Tooth disease type 2 (CMT2) or distal hereditary motor (dHMN). We aim to observe clinical spectrum a cohort patients with SORD‐related PN (SORD‐PN). Methods A total 107 AR sporadic CMT2/dHMN underwent molecular diagnosis by whole‐exome sequencing subsequent Sanger validation....
Mutations in ganglioside-induced differentiation-associated protein 1 (GDAP1) cause axonal or demyelinating Charcot-Marie-Tooth disease (CMT) with autosomal dominant recessive inheritance. In this study, we aim to report the genotypic and phenotypic features of GDAP1-related CMT a Chinese cohort.
Objective This study aims to delineate the clinical profiles of hereditary transthyretin amyloid polyneuropathy (ATTRv-PN) patients with A97S variant from southern China and molecular characteristics this mutant protein.
Objective: To study the prognostic factors for patients with stage ⅠB non-small cell lung cancer (NSCLC) after radical operation (R0). Methods: The clinical data of 458 who underwent resection NSCLC and were pathologically diagnosed from January 2009 to December 2010, reviewed retrospectively. Those cases include 269 male 189 female, aged between 28 88, a median age 61 years. Kaplan-Meier method Log rank test used univariate survival analysis Cox proportional hazards model multivariate...