A5101434474- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Myasthenia Gravis and Thymoma
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
- Meningioma and schwannoma management
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
National Clinical Research Center for Digestive Diseases
2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
The First People's Hospital of Xiaoshan District, Hangzhou
2025
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Sun Yat-sen University Cancer Center
2020-2024
Sun Yat-sen University
2020-2024
Southeast University
2024
Southwest University
2024
Determining the somatic mutations of epidermal growth factor receptor (EGFR)-pathway networks is key to effective treatment for non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors (TKIs).The mutation frequencies and their association gender, smoking history histology was analysed reported in this study. Five thousand one hundred twenty-five NSCLC patients’ pathology samples were collected, EGFR, KRAS, BRAF PIK3CA detected by multiplex testing. The status age, histological type...
Abstract Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma (RR-ENKTL), however, the complete response (CR) rate and duration of (DOR) need to be improved. This phase 1b/2 study investigated safety efficacy sintilimab, fully human anti-PD-1 antibody, plus chidamide, an oral subtype-selective histone deacetylase inhibitor in 38 patients with RR-ENKTL. Expected objective (ORR) combination was 80%. Patients received escalating...
Goose astrovirus (GoAstV) is an emerging avian pathogen that induces gout in goslings with a mortality of up to 50%. Organ damage caused by GoAstV infection was considered the cause gout, but it still unclear whether other factors are involved. Human and murine studies have linked gut microbiome-derived urate thus we hypothesized microbiome may also play important role induced infection. This study tested pathogenicity our isolated genotype 2 strain on goslings, while appearance clinical...
Herpesvirus-associated ubiquitin-specific protease (HAUSP) directly stabilizes the tumour suppressor p53 by de-ubiquitination. Therefore, HAUSP gene might play an important role in carcinogenesis. In this paper, expression and status have been studied relation to of target genes 131 patients with non-small cell lung cancer (NSCLC). was evaluated polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) followed sequencing. Quantitative reverse-transcription reaction...
Long non-coding RNAs (lncRNAs) have previously been reported to be involved in cancer invasion, proliferation and apoptosis. However, the association between lncRNA, H19, esophageal (EC) has remained elusive. In present study, reverse transcription quantitative‑polymerase chain reaction revealed that expression of H19 was significantly increased associated with tumor depth metastasis 133 EC samples. Furthermore, MTT Transwell assays overexpression vitro promoted invasion cell lines, whereas...
ErbB4 expression has been noted in various tumors, but its regulatory mechanism esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to investigate whether miR-302b regulates the at post-transcriptional level and determine expression, significance, function ESCC. We used real-time reverse transcriptase-polymerase chain reaction quantify 50 ESCC tissues analyzed relationship with clinicopathological factors survival. Then, we investigated regulation using...
Abstract Background Mediastinal teratoma is a rare disease, many cases were reported before, but few articles focus on large case analyses. The objective of this article to summarize the clinical characteristics benign mediastinal and experience surgical treatment, especially thoracoscopic surgery for teratoma. Methods data 108 patients with confirmed by operation pathology from January 1992 2018 analyzed retrospectively. symptoms, imaging examination, methods prognosis all analyzed. We...
Although PD-1/PD-L1 blockade therapy confers salutary effects across cancer types, their efficacy in Extranodal Natural killer/T-cell lymphoma (ENKTCL) patients is limited and unpredictable. Here, we comprehensively evaluated the expression profile of a panel immune-regulatory makers to identify novel prognostic biomarkers and/or therapeutic targets for this malignancy. Using immunohistochemistry multiplex immunofluorescence, found that VISTA (88.1%) was predominantly CD68+ macrophages much...
Abstract Aims This study aims to determine the predictive capability for metabolic dysfunction‐associated steatohepatitis (MASH) long before its diagnosis by using six previously identified diagnostic biomarkers steatotic liver disease (MASLD) with proteomic data from UK Biobank. Materials and Methods A nested case–control comprising a MASH group three age‐ sex‐matched control groups (metabolic steatosis, viral hepatitis normal controls) was conducted. Olink proteomics, anthropometric...
Massive splenomegaly is considered to pose a high risk for laparoscopic splenectomy (LS). We report case of supramassive wherein the patient successfully underwent LS guided by preoperative three-dimensional (3D) reconstruction. A 35-year-old female had history autoimmune hepatitis spanning 4 years, accompanied progressive splenomegaly. Her spleen grown size 27.3 cm in diameter, and consistent decline her blood cell counts been noted over same period. Considering significant enlargement...
BACKGROUND AND PURPOSE Ursolic acid (UA) has been extensively used as an anti‐leukaemic agent in traditional Chinese medicine. In the present study, we investigated ability of UA to induce apoptosis human leukaemia cells relation its effects on caspase activation, Mcl‐1 down‐regulation and perturbations stress‐induced signalling pathways such PKB JNK. EXPERIMENTAL APPROACH Leukaemia were treated with after which apoptosis, JNK evaluated. The anti‐tumour activity was evaluated using xenograft...
Thorax is the common place to develop Castleman disease (CD), but there no systemic clinical analysis for intrathoracic CD.We conducted a retrospective of 48 CD patients with definite pathological diagnosis who were hospitalized between 1992 and 2012 in Chinese tertiary referral hospital.The study included 16 cases unicentric (UCD) 32 multicentric (MCD). UCD younger than MCD (30.5y vs 41.6ys, P < 0.05). more symptomatic (50% 96.9%, 0.001) sicker UCD, including fever, hepatomegaly and/or...
Abstract Background Furmonertinib (AST2818) is a brain penetrant pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting both EGFR sensitizing mutations and T790M mutation. We report the pooled central nervous system (CNS) efficacy data of furmonertinib in patients with mutated non-small cell lung cancer (NSCLC) from two phase 2 studies. Methods This was pooled, post-hoc analysis studies (NCT03127449 [phase 2a study furmonertinib], NCT03452592 2b...
PURPOSE We investigated the possible association between integrin alpha3 and motility-related protein (MRP-1), cluster of differentiation antigen 9 (CD9) gene expression in non-small-cell lung cancer (NSCLC) evaluated prognostic significance expression. PATIENTS AND METHODS performed a retrospective study MRP-1/CD9 resected tumor tissues from 151 NSCLC patients using quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) immunohistochemistry. RESULTS The ratio...
Non-small cell lung cancer is one of the most common types cancer, and prognosis non-small still poor. Recent evidence has proved that long noncoding RNA involved in tumorigenesis. For expression profile been studied. Here, we identified a novel TRPM2-AS from published dataset found widely upregulated tissues compared with adjacent non-tumor tissues. Higher level was correlated higher TNM stages larger tumor size. Patients high had poor survival than those low level. We silenced by small...
Steroid associated osteonecrosis is difficult to treat. Teriparatide, as the only one bone anabolic drug, has achieved very promising effect in osteoporosis and other skeletal diseases. We carried out this animal study evaluate of subcutaneous injection teriparatide for steroid induced femoral head necrosis a rat model. 24 Sprague–Dawley male adult rats were included study. All randomized into 4 groups: 18 from LPS/MPS group, + PTH group NS given lipopolysaccharide (20 μg/kg)...
Several studies have identified miR-223 critically involved in various types of cancer, including pancreatic ductal adenocarcinoma (PDAC). However, its action and regulatory mechanisms PDAC remains largely unclear. In this study, we found that the expression levels were increased clinical samples with (81.6%). The upregulation increases proliferation, migration, invasive abilities cells vitro vivo. Mechanistically, directly targeted FBXW7 overexpression reverted miR-223- induced drastic...
Background/Aims: CircABCB10 function as an endogenous miRNA sponge plays important role in various tumors. This experimental design was based on circABCB10 to explore the pathogenesis of non-small cell lung cancer (NSCLC). Methods: CircRNA microarray used examine circRNA expression profiles from 3 NSCLC patients and paired healthy tissues. The miR-584-5p detected by q-PCR. CCK-8, colony formation, transwell assays study effects tumor growth migration invasiveness. To validate downstream...
Abstract It has been demonstrated in previous studies that lncPART1 is dysregulated non‐small cell lung cancer (NSCLC). However, the function of NSCLC unclear. Therefore, this experimental design was based on LncPART1 to explore pathogenesis NSCLC. Real‐time polymerase chain reaction used detect expression and miR‐17‐5p Cell Counting Kit ‐8, colony formation, transwell assays were examine effects proliferation migration invasiveness. Target gene prediction, luciferase reporter validate...