A5055753548- Gut microbiota and health
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Animal Disease Management and Epidemiology
- Long-Term Effects of COVID-19
- Veterinary medicine and infectious diseases
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- 2D Materials and Applications
- T-cell and Retrovirus Studies
- Intensive Care Unit Cognitive Disorders
- Inflammatory Bowel Disease
- Liver Disease and Transplantation
- interferon and immune responses
- Respiratory viral infections research
- Antimicrobial Peptides and Activities
- Tryptophan and brain disorders
Chinese University of Hong Kong
2021-2025
Huazhong University of Science and Technology
2022-2025
Guangdong Academy of Agricultural Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Shandong Agricultural University
2017-2023
Food and Health Bureau
2023
Shatin Hospital
2022
Wuhan Institute of Technology
2021-2022
Tianjin University
2020-2021
Xinxiang Medical University
2021
Background Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms viral clearance remains unclear. Objective To investigate whether gut microbiome composition is linked to post-acute syndrome (PACS), defined as at least one symptom 4 weeks of SARS-CoV-2 virus. Methods We conducted a prospective study 106 patients with spectrum severity followed up from admission 6 months and 68 non-COVID-19 controls. analysed serial faecal 258 samples using shotgun...
Abstract Wound management remains a major concern in clinical care. Conventional dressings and hydrogels delivering drugs or cells can drive wound healing. However, these approaches are limited either by unnecessary bleeding tissue tearing, sophisticated fabrication, high cost, drug‐related side effects. Herein, novel bioinspired glycopeptide hydrogel is rationally designed to mimic the glycoprotein components nanofibrous architecture of cutaneous extracellular matrix (ECM) for...
Abstract Systemic characterisation of the human faecal microbiome provides opportunity to develop non-invasive approaches in diagnosis a major disease. However, shared microbial signatures across different diseases make accurate challenging single-disease models. Herein, we present machine-learning multi-class model using metagenomic dataset 2,320 individuals with nine well-characterised phenotypes, including colorectal cancer, adenomas, Crohn’s disease, ulcerative colitis, irritable bowel...
BackgroundPost-acute COVID-19 syndrome (PACS) affects over 65 million individuals worldwide but treatment options are scarce. We aimed to assess a synbiotic preparation (SIM01) for the alleviation of PACS symptoms.MethodsIn this randomised, double-blind, placebo-controlled trial at tertiary referral centre in Hong Kong, patients with according US Centers Disease Control and Prevention criteria were randomly assigned (1:1) by random permuted blocks receive SIM01 (10 billion colony-forming...
The millions of deaths from cholera during the past 200 y, coupled with morbidity and mortality in Haiti since October 2010, are grim reminders that Vibrio cholerae , etiologic agent cholera, remains a scourge. We report isolation both V . O1 non-O1/O139 early epidemic samples collected victims 18 towns across eight Arrondissements Haiti. results showed two distinct populations V. coexisted epidemic. As was sole pathogen isolated 21% clinical specimens, its role this epidemic, either alone...
Abstract Motivation: A large and rapidly growing number of bacterial organisms have been sequenced by the newest sequencing technologies. Cheaper faster technologies make it easy to generate very high coverage genomes, but these advances mean that DNA preparation costs can exceed cost for small genomes. The need contain often results in creation only a single library, which turn introduces new challenges genome assembly methods. Results: We evaluated ability multiple programs assemble...
Three recently sequenced strains isolated from patients during an outbreak of Mycobacterium abscessus subsp. massiliense infections at a cystic fibrosis center in the United States were compared with 6 Kingdom and worldwide strains. Strains 2 outbreaks showed high-level relatedness each other major-level that caused soft tissue epidemic Brazil. We identified unique single-nucleotide polymorphisms strains, separate only genomic traits for subset isolates. Our findings highlight necessity...
Abstract Our knowledge of the role gut microbiome in acute coronavirus disease 2019 (COVID-19) and post-acute COVID-19 is rapidly increasing, whereas little known regarding contribution multi-kingdom microbiota host-microbial interactions to severity consequences. Herein, we perform an integrated analysis using 296 fecal metagenomes, 79 metabolomics, viral load 1378 respiratory tract samples, clinical features 133 patients prospectively followed for up 6 months. Metagenomic-based clustering...
Irritable bowel syndrome (IBS) is a heterogeneous condition with multifactorial pathogenesis. We studied deeply phenotyped individuals microbiota sequencing enrolled in the American Gut Project. The IBS subjects were matched by age, gender, body mass index, geography, and dietary patterns non-IBS controls. A total of 942 IBS-Diarrhea (IBS-D), IBS-Constipation (IBS-C), unclassified (IBS-U), controls included. compared taxonomic functional composition gut based on 16S data linked them clinical...
The treatment of myocardial infarction (MI) remains a substantial challenge due to excessive inflammation, massive cell death, and restricted regenerative potential, leading maladaptive healing process eventually heart failure. Current strategies regulating inflammation or improving cardiac tissue regeneration have limited success. Herein, hybrid hydrogel coassembled by acellular extracellular matrix (ECM) immunomodulatory glycopeptide is developed for endogenous after MI. constructs niche...
The emerging type II Weyl semimetal 1T' MoTe2 as a promising material in polarization-sensitive photodetectors has aroused much attention due to its narrow bandgap and intrinsic in-plane anisotropic crystal structure. However, the properties lead large dark current low response. Herein, we demonstrate for first time an all-2D MoTe2/MoS2 van der Waals (vdWs) heterojunction improve performance of realize polarization-sensitive, self-powered, broadband photodetection imaging. Owing built-in...
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis. While most cases are transmitted by Ixodes ticks, disease may also be through blood transfusion and perinatally. A comprehensive analysis genome composition, genetic diversity, gene expression profiling seven B. microti isolates revealed that variation in from Northeast United States almost exclusively associated with genes encoding...
Abstract The stagnation in the development of new antibiotics and concomitant high increase resistant bacteria emphasize urgent need for therapeutic options. Antimicrobial peptides are promising agents treatment bacterial infections recent studies indicate that Pep19-2.5, a synthetic anti-lipopolysaccharide (LPS) peptide (SALP), efficiently neutralises pathogenicity factors Gram-negative Gram-positive (lipoprotein/-peptide, LP) protects against sepsis. Here, we investigated potential...
Abstract Myocardial infarction (MI) remains a major threat to human health due the limited energy supply, disordered cell metabolism, massive cardiomyocyte death, and restricted regeneration. Although currently available therapies may relieve myocardial damage, restoring dysregulated metabolism normal levels has not yet been achieved. MOTS‐c recently identified as regulator of biological combat aging; however, its role in reprogramming cardiac be elucidated. Here, is chemically conjugated...
Goose astrovirus (GoAstV) is an emerging avian pathogen that induces gout in goslings with a mortality of up to 50%. Organ damage caused by GoAstV infection was considered the cause gout, but it still unclear whether other factors are involved. Human and murine studies have linked gut microbiome-derived urate thus we hypothesized microbiome may also play important role induced infection. This study tested pathogenicity our isolated genotype 2 strain on goslings, while appearance clinical...