A5004573744- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiovascular and Diving-Related Complications
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Conditions and Treatments
- Cardiac and Coronary Surgery Techniques
- Wound Healing and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiac tumors and thrombi
- Cardiovascular Health and Risk Factors
- Acute Myocardial Infarction Research
- Electrospun Nanofibers in Biomedical Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Kunming Medical University
2021-2025
Fuwai Yunnan Cardiovascular Hospital
2018-2025
Southern Medical University
2024
Nanfang Hospital
2024
Academy of Medical Sciences
2019-2024
Fu Wai Hospital
2018-2024
National Health and Family Planning Commission
2023-2024
State Key Laboratory of Cardiovascular Disease
2023-2024
Shanghai East Hospital
2024
Antibacterial hydrogels are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected-wound healing. The abuse of antibiotics leads to drug resistance. Recent developments have demonstrated that the delivery inorganic bactericidal agents can drive wound healing process; however, this approach is complicated by external light stimuli, cytotoxicity, nondegradability, sophisticated fabrication. Herein, an inherent antibacterial, bioresorbable hydrogel...
The treatment of difficult-to-heal wounds remains a substantial clinical challenge due to deteriorative tissue microenvironment including the loss extracellular matrix (ECM), excessive inflammation, impaired angiogenesis, and bacterial infection. Inspired by chemical components, fibrous structure, biological function natural ECM, antibacterial environment-responsive glycopeptide hybrid hydrogel was developed for chronic wound healing. can facilitate cell proliferation macrophage polarization...
<h3>Importance</h3> Dyslipidemia, the prevalence of which historically has been low in China, is emerging as second leading yet often unaddressed factor associated with risk cardiovascular diseases. However, recent national data on prevalence, treatment, and control dyslipidemia are lacking. <h3>Objective</h3> To assess community residents availability lipid-lowering medications primary care institutions China. <h3>Design, Setting, Participants</h3> This cross-sectional study used from...
The authors conducted a 2-year follow-up of 40 cardiovascular disease patients (mean age = 65.6 years (standard deviation, 5.8)) who underwent repeated measurements response before and during the 2008 Beijing Olympics (Beijing, China), when air pollution was strictly controlled. Ambient levels particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5), black carbon, nitrogen dioxide, sulfur ozone, carbon monoxide were measured continuously, validation concurrent real-time...
Abstract Mesoporous silica nanoparticles (MSNs) show great promise to be exploited as versatile multifunctional nanocarriers for effective cancer diagnosis and treatment. In this work, perfluorohexane (PFH)‐encapsulated MSNs with indocyanine green (ICG)–polydopamine (PDA) layer poly(ethylene glycol)–folic acid coating (designated MSNs‐PFH@PDA‐ICG‐PEG‐FA) are successfully fabricated achieve tumor ultrasonic (US)/near‐infrared fluorescence (NIRF) imaging well photothermal therapy...
Abstract Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult healing after tissue trauma. To simultaneously address these issues, composite polymer sponges for accelerating drug‐resistant infected are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts‐conjugated chitosan (QAS‐CS), collagen (COL) in aqueous solution, followed lyophilization. Composite (PAAS/QAS‐CS/COL, PQC) show highly porous...
The treatment of myocardial infarction (MI) remains a substantial challenge due to excessive inflammation, massive cell death, and restricted regenerative potential, leading maladaptive healing process eventually heart failure. Current strategies regulating inflammation or improving cardiac tissue regeneration have limited success. Herein, hybrid hydrogel coassembled by acellular extracellular matrix (ECM) immunomodulatory glycopeptide is developed for endogenous after MI. constructs niche...
This study aimed to analyse the global prevalence and disability trends of heart failure (HF) from 1990 2019, considering both sexes country-specific economic strata.
Patient frailty amongst patients with nonvalvular atrial fibrillation (NVAF) is associated adverse health outcomes and increased risk of mortality. Additional evidence needed to evaluate effective safe NVAF treatment in this patient population.This subgroup analysis the ARISTOPHANES study compared stroke/systemic embolism (S/SE) major bleeding (MB) frail prescribed nonvitamin K antagonist oral anticoagulants (NOACs) or warfarin.This comparative retrospective observational frail, older who...
Introduction: Ischemic heart disease (IHD) is the leading cause of mortality and disability worldwide. This study investigates global trend in IHD across 204 countries territories over past 30 years explores influence age, period, birth cohort.
We described a patient opted for Micra™ leadless pacemaker implantation, which was successfully guided by transthoracic echocardiography (TTE) without use of fluoroscopy during the whole procedure. Chest X-ray on second day confirmed an appropriate fixation, and device parameters remained stable in 3-month follow-up.
Objective Demonstrate the benefits of percutaneous atrial septal defect (ASD) closure under guidance transthoracic echocardiography (TTE) without fluoroscopy. Methods From February 2013 to April 2014, 127 consecutive patients with an isolated type II ASD were recruited undergo either TTE (n = 60, group) or TEE 67, guidance. The group received local anesthesia sedation propofol, and general endotracheal intubation. Follow‐up examinations performed for both groups at 1 month, 3 months, 6 year...
Poly(l-lactic acid) (PLLA) scaffolds have been used in regenerative medicine, however, they commonly suffer from low flexibility, restricting their application the repair and reconstruction of soft tissues. In this study, poly(l-lactide-co-ε-caprolactone) (PLCL) copolymers were examined to modulate elasticity PLLA with random presence CL units PLLA. Thermodynamic analysis revealed that introduction PCL could significantly decrease melting point glass transition temperature PLLA, benefiting...
Objective Tricuspid regurgitation (TR) is a common valvular heart disease with unsatisfactory medical therapeutics and high surgical mortality. The present study aims to evaluate the safety effectiveness of transcatheter tricuspid valve replacement (TTVR) in high-risk patients severe TR. Methods This was compassionate multicentre study. Between September 2018 November 2019, 46 TR who were not suitable for surgery received TTVR under general anaesthesia guidance trans-oesophageal...
Abstract Aims To increase the comprehensive understanding of trends in burden cardiovascular disease (CVD) attributable to low physical activity Western Pacific Region. Methods and results Based on data from Global Burden Disease study for years 1990–2019, an age–period–cohort analysis was conducted investigate CVD-related mortality Region associations with age, period, birth cohort. We also used joinpoint regression identify periods most substantial changes. The show that, witnessed a CVD...
Global, regional, and national time trends in disability-adjusted life years, mortality, variable risk factors of non-rheumatic calcified aortic valve disease, 1990–2019: an age-period-cohort analysis the Global Burden Disease 2019 study
Percutaneous patent ductus arteriosus (PDA) occlusion has become the preferred therapeutic option, which uses fluoroscopy as guidance. To reduce x-ray exposure, PDA using Amplatzer Duct Occluder II (ADO II) under guidance of transthoracic echocardiography only was conducted. This single center study aims to access safety and efficiency this new strategy.From June 2013 May 2015, 63 consecutive patients underwent echocardiography-guided through femoral artery. Outpatient follow-up conducted at...
To assess safety and effectiveness of symmetric asymmetric occluders in perventricular device closure without cardiopulmonary bypass perimembranous ventricular septal defects (pmVSDs).The present retrospective study enrolled 581 patients who underwent pmVSDs under transoesophageal echocardiography guidance from May 2011 to April 2016, outpatient electrocardiography transthoracic assessments at 1, 3, 6 12 months, yearly thereafter.The overall success rate implantation was 92.6% (43 surgical...