A5100685563- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- Cardiac Imaging and Diagnostics
- Amoebic Infections and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Computational Drug Discovery Methods
- Neonatal Health and Biochemistry
- Diet, Metabolism, and Disease
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Macrophage Migration Inhibitory Factor
- Cardiac Ischemia and Reperfusion
- Vitamin D Research Studies
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- CAR-T cell therapy research
- Case Reports on Hematomas
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Changhai Hospital
2022-2024
Second Military Medical University
2022-2024
Guangzhou Medical University
2024
The Third People's Hospital of Dalian City
2022
Dalian Medical University
2017-2022
Tianjin Chest Hospital
2020-2022
Zhongshan Hospital
2020-2021
Fudan University
2020-2021
Brigham and Women's Hospital
2009
<h3>Importance</h3> Dyslipidemia, the prevalence of which historically has been low in China, is emerging as second leading yet often unaddressed factor associated with risk cardiovascular diseases. However, recent national data on prevalence, treatment, and control dyslipidemia are lacking. <h3>Objective</h3> To assess community residents availability lipid-lowering medications primary care institutions China. <h3>Design, Setting, Participants</h3> This cross-sectional study used from...
Patients with type 2 diabetes lose β cells, but the underlying mechanisms are incompletely understood. Glucose-6-phosphate dehydrogenase (G6PD) is principal source of major intracellular reduc-tant, NADPH, which required by many enzymes, including enzymes antioxidant pathway. Previous work from our laboratory has shown that high glucose impairs G6PD activity in endothelial and kidney leads to decreased cell survival. Pancreatic cells highly sensitive increased ROS. This study aimed determine...
Pulmonary fibrosis poses a significant health threat with very limited therapeutic options available. In this study, we reported the enhanced expression of mesenchymal homobox 1 (MEOX1) in pulmonary patients, especially their fibroblasts and endothelial cells, confirmed MEOX1 as central orchestrator activation profibrotic genes. By high-throughput screening, identified Ailanthone (AIL) from natural compound library first small molecule capable directly targeting suppressing MEOX1. AIL...
Abstract Eukaryotic translation initiation factor 2 subunit beta (EIF2S2) is a protein that controls synthesis under various stress conditions and abnormally expressed in several cancers. However, there limited insight regarding the expression molecular role of EIF2S2 gastric cancer. In this study, we identified overexpression cancer by immunohistochemical staining found positive correlation between shorter overall survival disease-free survival. Functionally, revealed knockdown suppressed...
Grey Turner's and Cullen's signs are rare clinical signs, which most appear in patients with severe acute pancreatitis. The present patient complained of abdominal pain after coughing. However, contrast-enhanced CT revealed a hemorrhage the wall. Therefore, spontaneous wall was diagnosed. recovered through immobilization hemostasis therapy. This case report literature review aims to remind clinicians manifestations treatment hemorrhage.
Patients with coronary artery disease (CAD) often have normal blood cholesterol profiles that make it difficult to identify those at risk. The role of lipoprotein subfractions in the development CAD has attracted increasing attention, and can further stratify risks. We enrolled 1578 patients undergoing angiography not taking any lipid-lowering drugs; 1033 them were diagnosed CAD. severity was assessed using Gensini score (GS) divided into 3 groups. Multivariate regression analysis showed...
Abstract Backgrounds : To assess the effects of proprotein convertase subtilisin/kexin type 9 inhibitor (evolocumab) on lipoprotein particles subfractions with Nuclear Magnetic Resonance spectroscopy in patients acute coronary syndromes. Methods A total 99 consecutive ACS and poor lipid control were enrolled assigned to either experimental group (n = 54) or 45). The combination therapy PCSK9 (Repatha ® , 140mg, q2w) moderate statin (rosuvastatin, 10 mg, qn) was administered group,...
Objective To observe the effects of angiotensin Ⅱ type 1 receptor blocker, valsartan on release P-selectin in rat model myocardial ischemia reperfusion injury, and preliminary action mechanism valsartan. Methods Ninety wister rats were randomly divided into four groups, Group Ⅰ ( Sham operated group, n = 10), (Iscbemic 20), Ⅲ (Ischemic Group, =30) Ⅳ (Valsartan =30). was given by direct gastric garages 20mg/(kg·d). Ⅰ,Ⅱ, normal saline 2ml/d). After weeks pretreatment, middle point left...
Abstract Aim The purpose of this study was to compare clinicopathological features patients with non-schistosomal and schistosomal colorectal cancer explore the prognostic role schistosoma infection in cancer(CRC). Methods 354 cases CRC were retrospectively analyzed a tissue microarray format. Survival curves constructed by using Kaplan-Meier method. Univariate multivariate Cox proportional hazard regression models performed identify associations outcome variables. Results Patients...
Abstract Aim: To investigate the relationship between schistosomiasis and tumour infiltrating lymphocytes (TILs), prognostic value of TILs in schistosomal colorectal cancer (CRC). Background: The association CRC has long been suggested literature, but prognositic role never reported previously. Methods: Hematoxylin eosin (H&E)-stained sections 351 tumours, which were completely resected, evaluated for density intratumoural (iTIL) stromal compartments (sTIL). Its with clinicopathological...