A5100411680- RNA modifications and cancer
- Advanced Image and Video Retrieval Techniques
- Microwave Engineering and Waveguides
- Cancer-related gene regulation
- Anomaly Detection Techniques and Applications
- Advanced Antenna and Metasurface Technologies
- Adversarial Robustness in Machine Learning
- Antenna Design and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Image Retrieval and Classification Techniques
- Medical Image Segmentation Techniques
- Face and Expression Recognition
- Cancer-related molecular mechanisms research
- Orbital Angular Momentum in Optics
- Hybrid Renewable Energy Systems
- Cloud Computing and Resource Management
- Advanced Neural Network Applications
- EEG and Brain-Computer Interfaces
- IoT and Edge/Fog Computing
- Epigenetics and DNA Methylation
- Multimodal Machine Learning Applications
- Hydrogen Storage and Materials
- S100 Proteins and Annexins
- Spinal Cord Injury Research
- Diet and metabolism studies
Guangzhou Institutes of Biomedicine and Health
2025
State Key Laboratory of Respiratory Disease
2025
Chinese Academy of Sciences
2025
Jiangsu Province Hospital
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Nanjing Medical University
2024
State Key Laboratory of Oncology in South China
2024
Xidian University
2023-2024
Xi’an Children’s Hospital
2024
<h3>Importance</h3> Dyslipidemia, the prevalence of which historically has been low in China, is emerging as second leading yet often unaddressed factor associated with risk cardiovascular diseases. However, recent national data on prevalence, treatment, and control dyslipidemia are lacking. <h3>Objective</h3> To assess community residents availability lipid-lowering medications primary care institutions China. <h3>Design, Setting, Participants</h3> This cross-sectional study used from...
Abstract Neoadjuvant chemoimmunotherapy has emerged as a potential treatment option for resectable head and neck squamous cell carcinoma (HNSCC). In this single-arm phase II trial (NCT04826679), patients with locally advanced HNSCC (T2‒T4, N0‒N3b, M0) received neoadjuvant camrelizumab (200 mg), nab-paclitaxel (260 mg/m 2 ), cisplatin (60 ) intravenously on day one of each three-week cycle three cycles. The primary endpoint was the objective response rate (ORR). Secondary endpoints included...
We present an interpretable deep model for fine-grained visual recognition. At the core of our method lies integration region-based part discovery and attribution within a neural network. Our is trained using image-level object labels, provides interpretation its results via segmentation parts identification their contributions towards classification. To facilitate learning without direct supervision, we explore simple prior occurrence parts. demonstrate that this prior, when combined with...
Mild cognitive impairment (MCI) heightens Alzheimer's disease (AD) risk, with diabetes mellitus (DM) potentially exacerbating this vulnerability. This study identifies the optimal intervention period and neurobiological targets in MCI to AD progression using Disease Neuroimaging Initiative dataset.
The continuously evolving Omicron subvariants has diminished the effectiveness of almost all RBD-targeted antibodies in neutralizing these subvariants. development broad-spectrum is desired for addressing both current and future variants. Here, we identified a shark-derived nanobody, 79C11, that can neutralize tested so far, including BA.1 to JN.1 KP.2, exhibits comparable potency against SARS-CoV-1 pangolin coronavirus. Intranasal instillation 79C11 effectively prevent infection subvariant...
Explainability is increasingly crucial for real-world deployment of deep learning models, yet traditional explanation techniques can be prohibitively slow and memory- intensive on resource-constrained devices. This paper presents a novel lightweight ex- plainability framework that significantly reduces the computational cost generating explanations without compromising quality. My approach focuses an optimized Grad-CAM pipeline with sophisticated thresholding, advanced memory handling,...
Broadband orbital-angular-momentum (OAM) multiplexing is of great interest due to its ability increase channel capacity in wireless communications. However, broadband OAM-mode-reconfigurable transmitarrays have yet be developed. Here, a 1-bit electronically reconfigurable transmitarray for beam generation proposed, fabricated, and tested. The OAM includes $20\ifmmode\times\else\texttimes\fi{}20$ elements with phase resolution, each element controlled by two $p$-$i$-$n$ diodes minimum...
Abstract Spinal cord injury (SCI) can result in severe motor and sensory deficits, for which currently no effective cure exists. The pathological process underlying this is extremely complex involves many cell types the central nervous system. In study, we have uncovered a novel function macrophage G protein‐coupled receptor kinase‐interactor 1 (GIT1) promoting remyelination functional repair after SCI. Using GIT1 flox/flox Lyz2‐Cre (GIT1 CKO) mice, identified that deficiency macrophages led...
Abstract Background Immunotherapy is effective only in limited patients. It urgent to discover a novel biomarker predict immune cells infiltration status and immunotherapy response of different cancers. CLSPN has been reported play pivotal role various biological processes. However, comprehensive analysis cancers not conducted. Methods To show the whole picture cancers, pan-cancer was conducted 9125 tumor samples across 33 cancer types by integrating transcriptomic, epigenomic...
ABSTRACT Protein S100B is a clinically useful non‐invasive biomarker for brain cell damage. A rapid chemiluminescence immunoassay (CLIA) in human serum has been developed. Fluorescein isothiocyanate (FITC) and N ‐(aminobutyl)‐ ‐(ethylisoluminol) (ABEI) are used to label two different monoclonal antibodies of anti‐S100B. combines with labeled can form sandwiched immunoreaction. simplified separation procedure based on the use magnetic particles (MPs) that were coated anti‐FITC antibody...
BACKGROUND A rare autosomal recessive genetic disorder, 3M syndrome, is characterized by severe intrauterine and postnatal growth retardation. Children with syndrome typically exhibit short stature, facial deformities, long tubular bones, high vertebral bodies but generally lack mental abnormalities or other organ damage. Pathogenic genes associated include CUL7 , OBSL1 CCDC8 . The clinical molecular characteristics of patient are unique serve as important diagnostic indicators. CASE SUMMARY...
Topography measurement of high aspect ratio trench array using coherence scanning interferometry presents significant challenges because the numerical aperture detection light is constrained by trenches. Altering to penetrate sample like near-infrared for silicon could overcome this obstacle, but spreads light. This study introduces a model based on three-dimensional point spread function and assuming transparent light, which realized integrating rigorous electromagnetic field solution...
Purpose: Evidence is limited regarding the associations of different dietary patterns with cardiovascular disease (CVD) risk among population diabetes. Thus, we aimed to explore between three and CVD incidence Materials methods: We prospectively followed 22 473 diabetic patients from UK Biobank at baseline. The healthy pattern was derived a food frequency questionnaire; meanwhile, Alternate Mediterranean Diet (AMED) Dietary Approaches Stop Hypertension (DASH) diet were assessed based on...
Abstract Arrhythmia is a common abnormality of cardiac electrical activity. classification has enormous significance for the clinical diagnosis cardiovascular diseases. In this study, method multi-domain electrocardiogram feature extraction was put forward as to classify arrhythmia precisely. The RR intervals were extracted time domain feature. fifth level approximation coefficients wavelet decomposition adopted represent frequency Besides, sample entropy values six employed nonlinear These...
We aim to clarify the controversial associations between EBV-related antibodies and gastric cancer risk.We analysed serological Epstein-Barr nuclear antigen 1 immunoglobulin A (EBNA1-IgA) viral capsid (VCA-IgA) by enzyme-linked immunosorbent assay risk of in a nested case-control study originated from population-based nasopharyngeal carcinoma (NPC) screening cohort Zhongshan, city southern China, including 18 cases 444 controls. Conditional logistic regression was used calculate odds ratios...
Myocardial injury is the most prevalent and serious complication of sepsis. The potential puerarin (Pue) to treat sepsis-induced myocardial (SIMI) has been recently reported. Nevertheless, specific anti-SIMI mechanisms Pue remain largely unclear. Integrating network pharmacology, bioinformatics analysis, experimental validation, we aimed clarify Pue, thereby furnishing novel therapeutic targets. Pue-associated targets were collected from HIT, GeneCards, SwissTargetPrediction, SuperPred, CTD...