A5101428293- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- RNA modifications and cancer
- Reconstructive Surgery and Microvascular Techniques
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Esophageal and GI Pathology
- Brain Metastases and Treatment
- PARP inhibition in cancer therapy
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Reconstructive Facial Surgery Techniques
- Periodontal Regeneration and Treatments
- Protein Tyrosine Phosphatases
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Photodynamic Therapy Research Studies
- Peptidase Inhibition and Analysis
Sun Yat-sen University
2016-2024
Sun Yat-sen University Cancer Center
2016-2024
State Key Laboratory of Oncology in South China
2016-2024
Abstract Neoadjuvant chemoimmunotherapy has emerged as a potential treatment option for resectable head and neck squamous cell carcinoma (HNSCC). In this single-arm phase II trial (NCT04826679), patients with locally advanced HNSCC (T2‒T4, N0‒N3b, M0) received neoadjuvant camrelizumab (200 mg), nab-paclitaxel (260 mg/m 2 ), cisplatin (60 ) intravenously on day one of each three-week cycle three cycles. The primary endpoint was the objective response rate (ORR). Secondary endpoints included...
Ovarian cancer is a frequently-occurring reproductive system malignancy in females, which leads to an annual of over 100 thousand deaths worldwide.The electronic databases, including GEPIA, ONCOMINE, Metascape, and Kaplan-Meier Plotter, were used examine both survival transcriptional data regarding the cell division cycle associated (CDCA) gene family among ovarian patients.All CDCA genes expression levels up-regulated tissues relative those non-carcinoma counterparts. Besides, CDCA5/7...
Abstract Metastasis is the main cause of laryngeal cancer-related death; its molecular mechanism remains unknown. Here we identify protein arginine methyltransferase 5 (PRMT5) as a new metastasis-promoting factor in carcinoma, and explore underlying action regulating cancer progression. We illustrated that PRMT5 expression was positively correlated with tumor stages, lymphatic metastasis, unfavorable outcome. Functional assays revealed promoted carcinoma cell proliferation, migration,...
The tumor-targeting iLIP<sub>ICG</sub> provides a promising strategy to improve the precision imaging and effective phototherapy for treatment of laryngeal carcinoma.
6044 Background: Consensus on neoadjuvant treatment strategies for resectable head and neck squamous cell carcinoma (HNSCC) is not proposed currently. Preclinical clinical findings suggested that PD-1/CTLA-4 bispecific antibodies may have synergistic anti-tumor activity. This study aimed to explore the safety activity of cadonilimab in combination with platinum-based dual-drug chemotherapy locally advanced, HNSCC. Methods: In this open-label phase II trial, eligible patients untreated HNSCC...
Purpose: Anastomotic leakage is one of the most common complications esophagectomy, it serves as main causes postoperative death esophageal cancer. It clinical significance to try discover risk factors that cause anastomotic leakage. Methods: This retrospective study was conducted on 1,257 consecutive cancer patients who underwent esophagectomy with intrathoracic anastomosis from January 2010 December 2015 at a high volume center. Multivariate Logistic Regression analysis, Spearman rank...
Abstract Metastases lead to high mortality in laryngeal cancer, but the regulation of its underlying mechanisms remains elusive. We identified Protein arginine methyltransferase 5 (PRMT5) was significantly up‐regulated cancer tissues, which predicts poor patient prognosis. Functional assays demonstrated that PRMT5 overexpression promoted invasive capacity and lymph node metastasis vitro vivo. Mechanistic experiments suggested LATS2 a downstream target PRMT5. inhibition increased expression...
6069 Background: For resectable squamous cell carcinoma of the head and neck (HNSCC), novel therapeutic approaches are still needed to improve outcomes. Neoadjuvant immunochemotherapy (NICT) is considered as a potentially effective strategy. We therefore conducted pilot phase II trial explore efficacy safety neoadjuvant camrelizumab plus nab-paclitaxel cisplatin (NeoCPC) in patients with locoregionally advanced, HNSCC. Methods: In this open-label trial, untreated HNSCC (T2‒T4, N0‒N3b, M0;...
Esophagectomy is a high-risk surgical procedure with significant postoperative morbidity and mortality. Respiratory failure one of the most common complications after esophageal cancer surgery. The purpose this study was to explore risk factors that affect recovery respiratory in kind patients.Totally 2,360 patients underwent esophagectomies cervical anastomosis or intrathoracic our center from January 2012 December 2017. Among them, 130 requiring mechanical ventilation were included study....
Background and purpose: Maxillary cheek reconstruction is one of the most challenging tasks for surgeons. The purpose this study was to assess clinical application therapeutic efficacy maxillary through defects reconstructed with titanium mesh folded free anterolateral thigh flap. Materials methods: Between October 2010 May 2013, 16 patients were treated flap at Sun Yat-Sen University Cancer Center. Intra-operatively, fixed residual bones hard-tissue after tumor resection; then harvested...
Objective:To discuss the long term efficency of preoperative induction chemotherapy(IC)±radiotherapy on patients with resectable stage Ⅲ or Ⅳ squamous cell carcinoma oral cavity tongue(SCCOT).Method:During June 1996 to December 2005, 73 locally advanced SCCOT treated preoperatively IC(3 cycle cisplatin and 5 fluorouracil) followed by surgery(resection primary tumor neck)±radiotherapy in Cancer Center Sun Yat-sen University were enrolled our study. Five-year overall survival rates(OS), local...
To evaluate the feasibility and efficacy in selected T4a glottic cancer (thyroid cartilage invasion adherence to anterior commissure) treated with frontolateral vertical partial laryngectomy (FLVPL) laryngeal framework reconstruction using titanium mesh.Six patients limited thyroid destruction commissure, underwent FLVPL from 2009 2016 Sun Yat-Sen University Cancer Center. All were followed up postoperatively.All comprised radical tumor resection favorable functional outcomes, no aspiration...