A5100704655- MicroRNA in disease regulation
- Circular RNAs in diseases
- Psidium guajava Extracts and Applications
- Power Systems and Renewable Energy
- Advanced Photocatalysis Techniques
- Essential Oils and Antimicrobial Activity
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Ethnobotanical and Medicinal Plants Studies
- Cancer Immunotherapy and Biomarkers
- Carbohydrate Chemistry and Synthesis
- Medical and Biological Ozone Research
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Exercise and Physiological Responses
- CRISPR and Genetic Engineering
- Plant Toxicity and Pharmacological Properties
- Genomics, phytochemicals, and oxidative stress
- Plant-based Medicinal Research
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Ginger and Zingiberaceae research
- Heat shock proteins research
- Nanomaterials for catalytic reactions
- RNA and protein synthesis mechanisms
First Affiliated Hospital of Henan University
2020-2025
Guangxi Medical University
2024-2025
Bengbu Medical College
2025
Tumor Hospital of Guangxi Medical University
2024
Hebei Academy of Sciences
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
Hangzhou City University
2023
Zhejiang A & F University
2021-2022
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the of gene translation and subsequent protein synthesis by binding 5' terminal mRNA cap structure. We designed synthesized series novel compounds that display potent affinity against eIF4E despite their lack ribose moiety, phosphate, positive charge as present m7-GMP. biochemical activity compound 33 is 95 nM for an SPA assay. More importantly, has IC(50) 2.5 μM inhibiting cap-dependent rabbit reticular cell extract assay...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality. Circular RNAs (CircRNAs) have become a research hotspot in recent years for their vital roles cancer development and progression. This study aims to clarify circNTRK2 its underlying molecular mechanisms ESCC. Methods The levels circNTRK2, miR-140-3p, nuclear receptor-interacting protein 1 (NRIP1) mRNA were examined by qRT-PCR. proliferation ability was...
Immune checkpoint blockade (ICB) therapy, including antibodies targeting the programmed cell death protein 1 (PD-1) pathway, has significantly prolonged overall survival (OS) in patients with advanced cervical cancer (CC). ICB treatment affects both target cells and various components released by immune cells, which can be observed peripheral blood. However, there been limited research on dynamics of blood immunophenotyping its association OS CC receiving therapy. Patients persistent,...
Abstract Metastasis is the main cause of laryngeal cancer-related death; its molecular mechanism remains unknown. Here we identify protein arginine methyltransferase 5 (PRMT5) as a new metastasis-promoting factor in carcinoma, and explore underlying action regulating cancer progression. We illustrated that PRMT5 expression was positively correlated with tumor stages, lymphatic metastasis, unfavorable outcome. Functional assays revealed promoted carcinoma cell proliferation, migration,...
Breast cancer is one of the most common cancers among women. Tumor cell proliferation highly dependent on aerobic glycolysis, so regulating glycolysis in breast cells a promising therapeutic strategy. Resveratrol (Res), as potential new anti-breast drug, has been shown to regulate and inhibit metastasis recurrence cancer. The nano drug delivery system can metabolism by targeting signaling factors reaction products tumor process enhance anti-tumor effect. A albumin-modified layered double...
This study aimed to investigate the target genes of active components in Dingxiang Guanshitong (DGST) and evaluate their significance prognosis esophageal cancer (EC) through integrated approaches, including network pharmacology, molecular docking, prognostic analysis, vitro experiments. EC-related data were obtained from TCGA database, while SymMap TCMSP databases utilized identify DGST's bioactive targets. A comprehensive was constructed map component-target-pathway interactions....
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant cancers with high mortality around world. However, regulatory mechanism ESCC carcinogenesis not completely known. Here we demonstrate novel role miR-202 in regulating apoptosis. The analysis data obtained from GEO database showed that expression aberrantly decreased tumor tissue patients and cultured lines. After transfection mimic or inhibitor, apoptotic capacity cells was significantly increased by overexpression...
Okra is a kind of flavonoid-rich food which was reported to have variety health functions. Flavonoids are the major polyphenolic compounds in okra and thought play role reducing risk disease. The aim this study isolate identify flavonoids composition pods explore activity main components identified on inhibiting tumor cell proliferation vitro. Six individual were by HPLC-MS/MS: quercetin-3-gentiobioside (Q3G), quercetin-3-sambubioside (Q3S), rutin, quercetin-7-glucoside (Q7G), isoquercitrin...
Purpose PIWI-interacting RNAs (piRNAs) are a type of noncoding small RNA that can interact with PIWI-like RNA-mediated gene silencing (PIWIL) proteins to affect biological processes such as transposon through epigenetic effects. Recent studies have found piRNAs widely dysregulated in tumors and associated tumor progression poor prognosis. Therefore, this study aimed investigate the effect piR-1919609 on proliferation, apoptosis, drug resistance ovarian cancer cells. Methods In study, we used...
Melanin-concentrating hormone (MCH) is implicated in the feeding behavior mammals affording a potential target to control overeating people. Compound 1 (AMG 076) has been identified as potent MCHr1 antagonist for treatment of obesity. A synthesis suitable large-scale preparation this lead candidate was developed support preclinical studies. Robinson annulation benzylpiperidone and resolution desired enone from mixture diastereomers afforded key intermediate 6 after stereoselective...
Abstract A signal‐off photoelectrochemical (PEC) aptasensor was proposed for pathogenic bacteria detection based on graphite‐like carbon nitride decorated with NiO. The S. aureus be captured by the specific recognition of DNA aptamer, which immobilized PEC electrode surface according to effect carboxylic group and signal would obviously suppressed due transfer blocking electron donor active material steric hindrance electrostatic repulsion. showed excellent specificity high sensitivity ,...
Wild, edible plants have received increasing attention as an important complement to cultivate vegetables, they represent easily accessible source of nutrients, mineral elements, and antioxidants. In this study, the tender stems leaves Gonostegia hirta, species for which only scarce data are available in literature, thoroughly evaluated their nutritional profile, chemical characterization, antioxidant activity. Being considered underexploited, potentially plant, composition hirta was...
Compositional, functional, and nutritional properties are important for the use-value assessments of wild cultivated edible plants. The aim this study was to compare composition, bioactive compounds, volatile potential biological activities Zingiber striolatum. Various substances, such as soluble sugars, mineral elements, vitamins, total phenolics, flavonoids, volatiles, were measured analyzed using UV spectrophotometry, ICP-OES, HPLC, GC-MS methods. antioxidant capacity a methanol extract...
Eukaryotic mRNAs are appended at the 5' end, with 7-methylguanosine cap linked by a 5'-5'-triphosphate bridge to first transcribed nucleoside (m7GpppX). Initiation of cap-dependent translation mRNA requires direct interaction between structure and eukaryotic initiation factor eIF4E. Biophysical studies association eIF4E various analogs have demonstrated that m(7)GTP binds protein ca. -5.0 kcal/mol more favorably than unmethylated GTP. In this work, thermodynamic analysis binding process...
Solid polymer electrolytes have attracted considerable attention, owing to their flexibility and safety. At present, poly(ethylene oxide) is the most widely studied electrolyte matrix. It exhibits higher safety than polyolefin diaphragm used in traditional lithium-ion batteries. However, it readily crystallizes at room temperature, resulting low ionic conductivity, preparation process involves organic solvents. In this study, from perspective of molecular design, solvent-free polyaspartate...
MicroRNAs play an important role in regulating hypopharyngeal cancer development. miR-203 has been previously shown to possess antitumour capabilities many cancers, but not cancer.Using human normal and specimens, we explored the expression levels of two groups further correlated them with different stages lymph node metastasis.Applying pharynx FaDu cells lentiviral transduction technique, investigated effects on cell viability, migration invasion. Moreover, studied novel relationship...
Abstract Metastases lead to high mortality in laryngeal cancer, but the regulation of its underlying mechanisms remains elusive. We identified Protein arginine methyltransferase 5 (PRMT5) was significantly up‐regulated cancer tissues, which predicts poor patient prognosis. Functional assays demonstrated that PRMT5 overexpression promoted invasive capacity and lymph node metastasis vitro vivo. Mechanistic experiments suggested LATS2 a downstream target PRMT5. inhibition increased expression...
This study describes a polymer potentially used as vaccine adjuvant. We first synthesized novel polyacrylic acid modified by perfluorinated butanol—a bioactive compound that is biocompatible. The main aim was to functionalize the fluorine. functionalization could offer permanent graft an esterification reaction. chemical structure of has been characterized hydrogen nuclear magnetic resonance spectrum (1H-NMR) and fourier transform infrared (FT-IR). Thermal analysis showed reaction successful...