A5101457181- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Head and Neck Surgical Oncology
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- PARP inhibition in cancer therapy
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Alcohol Consumption and Health Effects
- Circadian rhythm and melatonin
- Genomics, phytochemicals, and oxidative stress
- Cryospheric studies and observations
- Climate variability and models
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Colorectal and Anal Carcinomas
First Affiliated Hospital of Henan University
2025
China Medical University
2019-2024
Sun Yat-sen University
2010-2024
Sun Yat-sen University Cancer Center
2010-2024
State Key Laboratory of Oncology in South China
2013-2024
Shaanxi Normal University
2024
People's Liberation Army 411 Hospital
2024
First Hospital of China Medical University
2024
Dalian University
2024
Nanjing University
2024
Abstract Programmed cell death protein-1 (PD-1)/programmed ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover nucleophosmin (NPM1) binds to promoter specifically TNBC cells and activates transcription, thus inhibiting T activity vitro vivo. Furthermore, demonstrate PARP1 suppresses transcription through its with the nucleic acid binding...
Abstract Neoadjuvant chemoimmunotherapy has emerged as a potential treatment option for resectable head and neck squamous cell carcinoma (HNSCC). In this single-arm phase II trial (NCT04826679), patients with locally advanced HNSCC (T2‒T4, N0‒N3b, M0) received neoadjuvant camrelizumab (200 mg), nab-paclitaxel (260 mg/m 2 ), cisplatin (60 ) intravenously on day one of each three-week cycle three cycles. The primary endpoint was the objective response rate (ORR). Secondary endpoints included...
Sirtuin 5 (SIRT5), a mitochondrial class III NAD-dependent deacetylase, plays controversial roles in tumorigenesis and chemoresistance. Accordingly, its role ovarian cancer development drug resistance is not fully understood. Here, we demonstrate that SIRT5 increased tissues compared to expression normal this predicts poor response chemotherapy. levels were also found be higher cisplatin-resistant SKOV-3 CAOV-3 cells than cisplatin-sensitive A2780 cells. Furthermore, protein was revealed...
Abstract Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but prognosis remains poor. This phase 3 trial (ClinicalTrials.gov: NCT03950154) assessed efficacy and adverse events (AEs) of PD-1 blockade-activated DC-CIK (PD1-T) cells with XELOX bevacizumab as a first-line in patients mCRC. A total 202 participants were enrolled randomly assigned 1:1 ratio to receive either (the control...
To determine the appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal carcinoma (NPC).After institutional review board approval and informed consent, 303 consecutive NPC treated definitive radiation therapy were examined after completion therapy. RLNs classified as on basis results magnetic resonance (MR) imaging follow-up.The receiver operating characteristic curve area under determined to assess accuracy different size diagnosis...
Bromodomain PHD finger transcription factor (BPTF), a core subunit of nucleosome-remodeling (NURF) complex, plays an important role in chromatin remodeling. However, its precise function and molecular mechanism involved hepatocellular carcinoma (HCC) growth are still poorly defined. Here, we demonstrated the tumor-promoting BPTF HCC progression. was highly expressed cells tumor tissues patients compared with normal liver tissues. Knockdown inhibited cell proliferation, colony formation stem...
Abstract Background As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 mutant melanomas. However, acquired drug resistance invariably develops after its initial treatment. Methods Immunohistochemical staining was performed to detect expression iNOS and hTERT, p-p65, Epcam, CD44, PCNA mice melanoma xenografts. The proliferation migration cells were detected by MTT, tumorsphere culture, cell cycle, apoptosis, AO/EB assay colony...
Sirtuin 5 (SIRT5) is a NAD+ -dependent class III protein deacetylase, and its role in prostate cancer has not yet been reported. Therefore, to explore the diagnosis treatment of cancer, we investigated effect SIRT5 on cancer. was assessed by immunohistochemistry 57 normal cancerous tissues. We found that tissue expression levels patients with Gleason scores ≥7 were significantly different from those <7 (P < .05, R > 0). Further, mass spectrometry pathway screening experiments showed...
Apatinib, a new-generation oral tyrosine kinase inhibitor targeting the vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathway, shows favorable therapeutic effects in various malignant tumors. However, its effect on ovarian cancer has not yet been characterized. Here, we demonstrated that apatinib inhibited cell and migration concentration-dependent manner. Further, found could directly act tumor cells promote ROS-dependent apoptosis autophagy. Mechanistically, showed...
Acute myeloid leukemia (AML) with an internal tandem duplication in Fms-related tyrosine kinase 3 (FLT3-ITD) is identified as a subgroup poor outcome and intrinsic resistance to chemotherapy therefore urgent need for development of novel therapeutic strategies. Methods: The antitumor effects melatonin alone or combined sorafenib were evaluated via flow cytometry immunoblotting assays FLT-ITD AML cells. Also, the ex vivo models used test synergistic against FLT3/ITD mutation. Results: Our...
Abstract Long noncoding RNAs (LncRNAs) have been gaining attention as potential therapeutic targets for lung cancer. In this study, we investigated the expression and biological behavior of lncRNA DARS‐AS1, its predicted interacting partner miR‐302a‐3p, ACAT1 in nonsmall cell cancer (NSCLC). The transcript level was analyzed using qRT‐PCR. Endogenous of—and changes in—AKT/ERK pathway‐related proteins were determined western blotting. MTS, Transwell, apoptosis experiments used to investigate...
Chaihu and Longgu Muli Decoction has demonstrated significant efficacy in the treatment of tachyarrhythmia accompanied by anxiety depression. However, there is a lack standardized guidelines for its clinical application. In this study, was investigated through extensive research on ancient modern literature, as well collection medical records. The basic information, medication details, diagnostic information from records, personal experience cases were extracted analyzed to preliminarily...
Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths. However, it unclear whether Ku80 regulates tumor growth in human melanoma. In this study, we screened a siRNA library targeting 6024 genes identified as potential therapeutic target melanoma cells. Knockdown significantly suppressed cell proliferation induced apoptosis, well enhanced antitumor effect melatonin vitro vivo. Overexpression Ku80, however, promoted increased insensitivity cells to...
Hepatocellular carcinoma (HCC) has a high mortality rate and lacks an effective therapeutic target. Elevated expression of human telomerase reverse transcriptase (TERT) is important hallmark in cancers, but the mechanism by which TERT activated differentially cancers poorly understood. Here, we have identified nuclear receptor coactivator-3 (NCOA3) as new modulator tumor growth HCC. NACO3 specifically binds to promoter at -234 -144 region transcriptionally activates expression. NCOA3...
Abstract RUNX1, a member of the RUNX family metazoan transcription factors, participates in regulation differentiation, proliferation, and other processes involved growth development. It also functions occurrence development tumors. However, role mechanism action RUNX1 non‐small cell lung cancer (NSCLC) are not yet clear. We used bioinformatics approach as well vitro vivo assays to evaluate NSCLC molecular mechanisms underlying its effects. Using TCGA, GEO, GEPIA (Gene Expression Profiling...
RBFOX3, an RNA-binding fox protein, plays important role in the differentiation of neuronal development, but its chemosensitivity hepatocellular carcinoma (HCC) to 5-FU is unknown.In this study, we examined biological functions RBFOX3 and effect on HCC cells vitro a mouse xenograft model.RBFOX3 was found have elevated expression cell lines tissue samples, knockdown inhibited proliferation. Moreover, improved inhibitory 5-fluorouracil (5-FU) proliferation, migration invasion, enhanced...
Cervical cancer is an aggressive cutaneous malignancy, illuminating the molecular mechanisms of tumorigenesis and discovering novel therapeutic targets are urgently needed.KMT2A a transcriptional co-activator regulating gene expression during early development hematopoiesis, but role KMT2A in cervical remains unknown.Here, we demonstrated that regulated growth via targeting VADC1.Knockdown significantly suppressed cell proliferation migration induced apoptosis cells, accompanying with...
PI3KCA and mutant p53 are associated with tumorigenesis the development of cancers. NVP-BKM120, a selective pan-PI3K inhibitor, exerts antitumor activity by suppressing PI3K signaling pathway. Prima-1Met, low molecular weight compound, can rescue gain-of-function restoring its transcriptional function. In this study, we investigated whether inhibition combined reactivation could enhance effect in thyroid cancer cells.The effects BKM120 Prima-1Met on proliferation, apoptosis, migration...