A5051489086- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Photodynamic Therapy Research Studies
- Cardiac Imaging and Diagnostics
- AI in cancer detection
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Breast Lesions and Carcinomas
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- MRI in cancer diagnosis
- Ferroptosis and cancer prognosis
- Electrospun Nanofibers in Biomedical Applications
- Ultrasound Imaging and Elastography
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Luminescence and Fluorescent Materials
- Phagocytosis and Immune Regulation
- Advanced MRI Techniques and Applications
- Ubiquitin and proteasome pathways
- Cardiovascular Disease and Adiposity
Chongqing Medical University
2016-2025
Second Affiliated Hospital of Chongqing Medical University
2016-2025
Dalian Medical University
2016-2025
Capital Medical University
2024
Guangdong Polytechnic of Science and Technology
2024
Institute of Science and Technology
2024
Harbin Medical University
2020
Second Affiliated Hospital of Harbin Medical University
2020
Baotou Central Hospital
2017
Creative Commons
2017
Abstract Proteolysis targeting chimeras (PROTACs) technology is an emerging approach to degrade disease‐associated proteins. Here, we report carbon‐dot (CD)‐based PROTACs (CDTACs) that membrane proteins via the ubiquitin‐proteasome system. CDTACs can bind programmed cell death ligand 1 (PD‐L1), recruit cereblon (CRBN) induce PD‐L1 ubiquitination, and them with proteasomes. Fasting‐mimicking diet (FMD) also used enhance cellular uptake proteasome activity. More than 99 % or 90 of in CT26...
Abstract Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature damage‐repair capabilities malignant tumors strongly limit efficacy treatments based on a single treatment mode. To address this challenge, self‐reinforced bimetallic Mito‐Jammer is developed by incorporating doxorubicin (DOX) calcium peroxide (CaO 2 ) into hyaluronic (HA) ‐modified...
Abstract Background The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, metastasis, current apoptosis-based fails to elicit sufficient immune response HCC. Results A smart responsive bimetallic nanovaccine was constructed induce immunogenic cell death (ICD) through pyroptosis enhance the efficacy of cGAS-STING pathway. composed...
Thrombotic disease is extremely harmful to human health, but early detection and treatment can help improve prognoses reduce mortality. To date, few studies have used MR molecular imaging in the of thrombi dynamic monitoring thrombolytic efficiency. In this article, we construct Fe3O4-based poly(lactic-co-glycolic acid) (PLGA) nanoparticles use targeted thrombolysis using MRI monitoring. Cyclic arginine-glycine-aspartic peptide (cRGD) was grafted onto chitosan (CS) surface synthesize a...
Multifunctional nanoplatforms with diagnostic-imaging and targeted therapeutic functionality (theranostics) are of great interest in the field precision nanomedicine. The emerging sonodynamic therapy (SDT) combined sonosensitizers under guidance photoacoustic (PA) imaging is highly expected to accurately eliminate cancer cells/tissue.
Disulfiram (DSF), a U.S. Food and Drug Administration (FDA)-approved drug for the treatment of chronic alcoholism, is also used as an antitumor in combination with Cu2+ ions. However, studies have shown that endogenous dose tumor tissues still insufficient to form relatively high levels bis(N,N-diethyldithiocarbamate) copper(II) complex (denoted Cu(DTC)2) selectively eradicate cancer cells. Here, DSF-loaded hollow copper sulfide nanoparticles (DSF@PEG-HCuSNPs) were designed achieve...
Mono-therapeutic modality has limitations in combating metastatic lesions with complications. Although emerging immunotherapy exhibits preliminary success, solid tumors are usually immunosuppressive, leading to ineffective antitumor immune responses and immunotherapeutic resistance. The rational combination of several therapeutic modalities may potentially become a new strategy effectively combat cancer.Poly lactic-co-glycolic acid (PLGA, 50 mg) nanospheres were constructed photothermal...
In thrombotic diseases, the effects of reactive oxygen species (ROS)-mediated oxidative stress as a "perpetrator" in thrombosis must be resolved. Accordingly, an insufficient understanding thrombus therapy prompted authors to pursue more comprehensive and efficient antithrombotic treatment strategy. A Prussian blue (PB)-based nanodroplet system (PB-PFP@PC) is designed using PB perfluorinated pentane (PFP) core, targeting peptide (CREKA, Cys-Arg-Glu-Lys-Ala) attached poly(lactic-coglycolic...
Currently, inadequate early diagnostic methods hinder the prompt treatment of patients with heart failure and myocardial fibrosis. Magnetic resonance imaging is gold standard noninvasive method; however, its effectiveness constrained by low resolution challenges posed certain who cannot undergo procedure. Although enhanced computed tomography (CT) offers high resolution, arise owing to unclear differentiation between fibrotic normal tissue. Furthermore, although echocardiography real-time...
A minimally invasive, highly efficient and versatile strategy is proposed for localized tumor regression by developing a smart injectable liquid–solid phase-transformation organic–inorganic hybrid composite material, i.e., magnetic-Fe-powder-dispersed PLGA (Fe/PLGA) implants magnetic hyperthermia therapy of cancer. As service to our authors readers, this journal provides supporting information supplied the authors. Such materials are peer reviewed may be re-organized online delivery, but not...
Background: Minimally invasive modalities are of great interest in the field treating bone tumors. However, providing reliable mechanical support and fast killing tumor cells to achieve rapid recovery physical function is still challenging clinical works. Methods: A material with two functions, magnetic thermal ablation, was developed from Fe3O4 nanoparticles (NPs) distributed a polymethylmethacrylate (PMMA) cement. The properties efficiency field-induced ablation were systematically...
Retinoblastoma (RB) is prone to delayed diagnosis or treatment and has an increased likelihood of metastasizing. Thus, it crucial perform effective imaging examination provide optimal RB prevent metastasis. Nanoparticles that support diagnostic targeted therapy are expected noninvasively integrate tumor treatment. Herein, we report a multifunctional nanoparticle for multimodal imaging-guided low-intensity focused ultrasound (LIFU)/immunosynergistic therapy. Magnetic hollow mesoporous gold...
Breast cancer is a major threat to health and lives of females. Biomimetic nanotechnology brought brighter hope for early diagnosis treatment breast cancer. Here, we proposed platelet (PLT) membrane-derived strategy enhanced photoacoustic (PA)/ultrasonic (US)/fluorescence (FL) multimodal imaging augmented synergistic photothermal/chemotherapeutic efficacy in tumor cells. A PA contrast photothermal agent, nanocarbons (CNs), chemotherapeutic FL material, doxorubicin (DOX), perfluoropentane...
Rationale: Multidrug resistance (MDR) and metastasis of breast cancer remain major hurdles in clinical anticancer therapy.The unsatisfactory outcome is largely due to insufficient cytotoxicity chemotherapeutic agents limited immunogenic cell death (ICD).On the other hand, efflux proteins, especially P-glycoprotein (P-gp), can recognize promote drugs from tumor cells.Methods: In this study, silver nanoparticles (Ag NPs) peptide-functionalized doxorubicin ( P DOX) were used prepare a...
The rapid development of nanomedicine has brought hope and confidence to the precise treatment tumors. However, efficacy nanoparticle-mediated therapy is severely limited due phagocytosis clearance by macrophages. CD47 a well-documented ″don't eat me″ signaling molecule that binds SIRPα receptor on macrophage surface, inhibiting phagocytic behavior In this study, CD47-overexpressing cancer cell membranes were used coat hollow copper sulfide nanoparticles. nanoparticles shown have an extended...
Proteolysis-targeting chimera (PROTAC) has emerged as a promising strategy for degrading proteins of interest. Peptide-based PROTACs offer several advantages over small-molecule-based PROTACs, such high specificity, low toxicity, and large protein–protein interaction surfaces. However, peptide-based have intrinsic shortcomings that strongly limit their application including poor cell permeability stability potency. Herein, we designed nanosized hybrid PROTAC (GNCTACs) to target degrade human...
Metastasis and recurrence are notable contributors to mortality associated with breast cancer. Although immunotherapy has shown promise in mitigating these risks after conventional treatments, its effectiveness remains constrained by significant challenges, such as impaired antigen presentation dendritic cells (DCs) inadequate T cell infiltration into tumor tissues. To address limitations, we developed a multifunctional nanoparticle platform, termed GM@P, which consisted of hydrophobic shell...
Functionalized nanomaterials with near-infrared (NIR) responsive capacity are quite promising for theranostic treatment of tumors, but formation NIR enhanced ability and excellent biocompatibility is still very challenging. Herein, PEGylated indocyanine green (ICG)-loaded polypyrrole nanoparticles (PPI NPs) were designed successfully formed through selecting polydopamine as the linkage between each component, demonstrating against tumor. By combining in vitro cell study vivo assay, PPI NPs...
Adenosine triphosphate (ATP), as a key substance for regulating tumor progression in the microenvironemnt (TME), is an emerging target theranostics. Herein, we report minimalist but versatile nanoplatform with simultaneously TME-responsive drug release, TME-enhanced imaging, ATP-depletion sensitized chemotherapy and photothermal therapy intelligent Methods: The Fe3+ tannic acid (TA) coordination were self-deposited on doxorubicin (Dox) facile method to prepare Dox-encapsulated nanoparticles...
Photothermal therapy (PTT) as a noninvasive and effective thermal therapeutic approach has attracted tremendously increasing interest because it can effectively eliminate the primary tumor generate tumor-associated antigens, which could elicit antitumor immune responses. Herein, we report on rational design fabrication of copper sulfide (CuS)-based nanoplatform for cancer photothermal immunotherapy. The as-prepared core–shell CuS@mSiO2-PFP-PEG (CPPs) nanocomposites possess high...
Abstract Background Combined therapy based on the effects of cascade reactions nanoplatforms to combat specific solid tumor microenvironments is considered a cancer treatment strategy with transformative clinical value. Unfortunately, an insufficient O 2 supply and lack visual indication hinder further applications most for therapy. Results A visualizable nanoplatform liposome nanoparticles loaded GOD, H(Gd), PFP grafted peptide tLyP-1, named tLyP-1 H(Gd)-GOD@PFP, was constructed. The...
Currently, the limited efficacy of antithrombotic treatments is attributed to inadequacy pure drugs and low ability target thrombus site. More importantly, timely thrombolysis essential reduce sequelae cardiovascular disease, but ischemia–reperfusion injury (IRI) remains a major challenge that must be solved after blood flow recovery. Herein, multifunctional therapeutic nanoparticle (NP) based on Fe3O4 strontium ions encapsulated in mesoporous polydopamine was successfully constructed then...