A5100433527- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Nanoparticle-Based Drug Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Electron Spin Resonance Studies
- Microfluidic and Bio-sensing Technologies
Chongqing Medical University
2017-2022
Second Affiliated Hospital of Chongqing Medical University
2017-2022
Dalian Medical University
2017-2022
University of Cincinnati
2016
Multimodal molecular imaging has shown promise as a complementary approach to thrombus detection. However, the simultaneous noninvasive detection and lysis of thrombi for cardiovascular diseases remain challenging. Herein, perfluorohexane (PFH)-based biocompatible nanostructure was fabricated, namely, as-prepared Fe3O4-poly(lactic-co-glycolic acid)-PFH-CREKA nanoparticles (NPs), which combine phase transition (PT) thrombolysis capabilities with properties conducive multimodal imaging. This...
In thrombotic diseases, the effects of reactive oxygen species (ROS)-mediated oxidative stress as a "perpetrator" in thrombosis must be resolved. Accordingly, an insufficient understanding thrombus therapy prompted authors to pursue more comprehensive and efficient antithrombotic treatment strategy. A Prussian blue (PB)-based nanodroplet system (PB-PFP@PC) is designed using PB perfluorinated pentane (PFP) core, targeting peptide (CREKA, Cys-Arg-Glu-Lys-Ala) attached poly(lactic-coglycolic...
Thrombotic disease is extremely harmful to human health, and early detection treatment can improve the prognosis reduce mortality. Multimodal molecular imaging provide abundant information about thrombi, but date, few studies have used multimodal multifunctional nanoparticles (NPs) for thrombus targeting thrombolysis. In this study, phase transition NPs (EWVDV-Fe-Ink-PFH NPs) were constructed first time using a three-step emulsification carbodiimide method, physical chemical properties of...
Platelet activation and subsequent aggregation are the initial stages of thrombosis. A molecular probe that specifically targets activated platelets remains retained under high shear stress in vivo can enhance imaging effect to achieve early accurate diagnosis.In this study, we constructed nanoparticles (NPs) using polydopamine carry two peptides simultaneously bind integrin αIIbβ3 P-selectin on targeting NPs thrombus.The specificity binding stability red white thrombi were demonstrated...
Arterial thrombosis is a serious threat to human health. Recently, many thrombus-targeted nanoparticles (NPs) have been constructed for detecting thrombi or monitoring thrombolysis, but their thrombus-targeting performance limited. Considering this drawback, we designed specific bionic system with enhanced ability.In the system, gelatin was chosen as carrier, and Fe3O4 served magnetic navigation medium resonance (MR) imaging agent. The CREKA peptide, which targets fibrin, conjugated surface...
There have been many recent reports of molecular probes for thrombi but with unsatisfactory in vivo targeting effects, which could be related to the blood flow velocity vivo. Therefore, it is worth explaining relationship between effect and velocity.In this study, we constructed a platelet-targeting nanoparticle (NP) based on EWVDV P-selectin combined phase transition material perfluorohexane India ink achieve multimodal imaging thrombi. We studied NPs rabbit under different velocities...