A5057986783- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Venous Thromboembolism Diagnosis and Management
- Photoacoustic and Ultrasonic Imaging
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Pancreatic function and diabetes
- Liver physiology and pathology
- Respiratory Support and Mechanisms
- Cancer-related molecular mechanisms research
- Blood properties and coagulation
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Urologic and reproductive health conditions
- Apelin-related biomedical research
- Peroxisome Proliferator-Activated Receptors
- Clinical Nutrition and Gastroenterology
- Antiplatelet Therapy and Cardiovascular Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Zebrafish Biomedical Research Applications
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
Ministry of Industry and Information Technology
2024-2025
Nanjing University of Science and Technology
2024-2025
Nanjing Drum Tower Hospital
2024-2025
Sichuan University
2024
West China Hospital of Sichuan University
2024
Chongqing Medical University
2022-2023
Second Affiliated Hospital of Chongqing Medical University
2022-2023
Dalian Medical University
2022-2023
Digital Science (United States)
2020
In thrombotic diseases, the effects of reactive oxygen species (ROS)-mediated oxidative stress as a "perpetrator" in thrombosis must be resolved. Accordingly, an insufficient understanding thrombus therapy prompted authors to pursue more comprehensive and efficient antithrombotic treatment strategy. A Prussian blue (PB)-based nanodroplet system (PB-PFP@PC) is designed using PB perfluorinated pentane (PFP) core, targeting peptide (CREKA, Cys-Arg-Glu-Lys-Ala) attached poly(lactic-coglycolic...
Currently, the limited efficacy of antithrombotic treatments is attributed to inadequacy pure drugs and low ability target thrombus site. More importantly, timely thrombolysis essential reduce sequelae cardiovascular disease, but ischemia–reperfusion injury (IRI) remains a major challenge that must be solved after blood flow recovery. Herein, multifunctional therapeutic nanoparticle (NP) based on Fe3O4 strontium ions encapsulated in mesoporous polydopamine was successfully constructed then...
As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of RIPK1...
As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of RIPK1...
Venous thromboembolism (VTE) is a prevalent public health issue worldwide. Before treatment, spatiotemporally accurate thrombus detection essential. However, with the currently available imaging technologies, this challenging. Herein, development of novel fibrin-specific nanoprobe (NP) based on conjugation poly(lactic-co-glycolic acid) pentapeptide Cys-Arg-Glu-Lys-Ala (CREKA) for selective and semiquantitative in vivo presented. By integrating Fe3 O4 NIR fluorochrome (IR780), NP can function...
Arterial thrombosis is a serious threat to human health. Recently, many thrombus-targeted nanoparticles (NPs) have been constructed for detecting thrombi or monitoring thrombolysis, but their thrombus-targeting performance limited. Considering this drawback, we designed specific bionic system with enhanced ability.In the system, gelatin was chosen as carrier, and Fe3O4 served magnetic navigation medium resonance (MR) imaging agent. The CREKA peptide, which targets fibrin, conjugated surface...
As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of RIPK1...
Thrombosis is a common disease that poses great threat to life and health. Most thrombolytic effects of traditional treatments or nanomedicine are not efficient safe enough. Therefore, we designed nanoparticle (NP) with combination phase transition material drugs for thrombolysis.A thrombus fibrin-targeted NP was contained perfluorohexane (PFH) the drug rtPA core, CREKA polypeptides attached shell PLGA NPs. Characterization ultrasound imaging NPs carried out under low-intensity focused...
To examine if METTL5 promotes the proliferation of nonsmall cell lung cancer (NSCLC) cells by interacting with IGF2BP3.
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Abstract As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of...
Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous liver tumor. The associations between histopathological feature and prognosis of ICC are limited. present study aimed to investigate the prognostic significance glandular structure tumor budding in ICC. Patients received radical hepatectomy for were included. Glandular detected by Hematoxylin-eosin staining. Kaplan–Meier method Cox proportional hazards regression model used calculate survival hazard ratio. Based on results...
ABSTRACT The increasing incidence of cancer underscore the necessity investigating contributors such as endocrine‐disrupting chemicals (EDCs), including bisphenol A (BPA). Although BPA's risks are well‐documented, comprehensive studies on its substitutes, B (BPB), limited. Dysregulated lipid metabolism is a hallmark progression. Our previous work demonstrated that BPA and S (BPS) disrupt via peroxisome proliferator‐activated receptor γ (PPARγ) pathway. We hence hypothesized BPB might...
Alveolar soft part sarcoma (ASPS) of the orbit is exceedingly rare and little known regarding its radiologic features. Here, we reviewed CT MRI findings one case ASPS with emphasis on salient imaging
The research on binocular ranging technology for transmission lines based