A5100680142- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Parathyroid Disorders and Treatments
- Advanced Breast Cancer Therapies
- Immune cells in cancer
- Lipoproteins and Cardiovascular Health
- Pancreatic and Hepatic Oncology Research
- Bayesian Methods and Mixture Models
- T-cell and B-cell Immunology
- Medical Imaging and Pathology Studies
- dental development and anomalies
- Atherosclerosis and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Statistical Methods and Inference
- Traditional Chinese Medicine Analysis
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Systemic Lupus Erythematosus Research
- Cardiac Ischemia and Reperfusion
Chongqing Cancer Hospital
2022-2025
Chongqing University
2022-2025
People's Hospital of Cangzhou
2025
Nanjing Medical University
2011-2024
Jiangsu Province Hospital
2011-2024
Novartis (Switzerland)
2008-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
King's College Hospital NHS Foundation Trust
2024
Xi'an Jiaotong University
2019-2023
Xian Mental Health Center
2013-2023
Among patients with chronic heart failure, angiotensin-converting–enzyme (ACE) inhibitors reduce mortality and hospitalization, but the role of a renin inhibitor in such is unknown. We compared ACE enalapril aliskiren (to test superiority or at least noninferiority) combination two treatments superiority) failure reduced ejection fraction.
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter...
Recent advancements in novel antibody-drug conjugates (ADCs) have demonstrated efficacy patients with human epidermal growth factor receptor 2 (HER2)-ultralow breast cancer (BC), expanding the eligibility for anti-HER2 targeted therapy to include some previously categorized as HER2 immunohistochemistry (IHC) 0. This expansion underscores need pathologists accurately differentiate HER2-null and HER2-ultralow. Thirty-six from four centers nationwide conducted microscopic visual assessments on...
Hepatocellular carcinoma is one of most common solid cancers worldwide. Sorafenib indicated as a treatment for advanced hepatocellular (HCC). However, the clinical efficacy sorafenib has been severely compromised by development drug resistance, and precise mechanisms resistance remain largely unknown. Here we found that cell surface molecule, CD24, overexpressed in tumor tissues sorafenib-resistant lines. Moreover, there positive correlation between CD24 expression levels resistance. In HCC...
ABSTRACT Background Male breast cancer (MBC) is rare and often treated using evidence from female (BC) trials due to limited male participation. Previous estimates lacked global coverage completeness. We aimed quantify the MBC burden 1990 2021 evaluate its current status trends. Methods Based on of disease (GBD) database, we gathered analyzed data incidence, death, disability‐adjusted life years (DALYs) while utilizing age‐standardized rates (ASRs) as indicators for these measurements. Our...
Abstract Background and Aims About 20% of patients receiving nucleos(t)ide analogues treatment experienced low‐level viraemia (LLV), which is associated with progression liver fibrosis high risk hepatocellular carcinoma. We aimed to evaluate the effectiveness safety switching from entecavir (ETV) tenofovir alafenamide fumarate (TAF) in ETV‐treated LLV. Methods In this prospective study, LLV, presented our hospital December 2018 October 2019, were enrolled. Switching TAF or continuing ETV was...
To evaluate the efficacy, safety, and pharmacokinetics (PK) of inclisiran in Japanese patients with high cardiovascular risk elevated low-density lipoprotein cholesterol (LDL-C).
Little is known on the cost-effectiveness of novel regimens for hepatitis C virus (HCV) compared with standard-of-care pegylated interferon (pegIFN) and ribavirin (RBV) therapy in developing countries. We evaluated sofosbuvir/ledipasvir 12 weeks a 48-week pegIFN-RBV regimen Chinese patients genotype 1b HCV infection by economic regions.A decision analytic Markov model was developed to estimate quality-adjusted-life-years, lifetime cost incremental ratios (ICERs). SVR rates direct medical...
Background: Approximately 13% of black individuals carry 2 copies the apolipoprotein L1 ( APOL1 ) risk alleles G1 or G2, which are associated with 1.5- to 2.5-fold increased chronic kidney disease. There have been conflicting reports as whether an association exists between and cardiovascular disease (CVD) that is independent effects on We sought test G1/G2 coronary artery disease, peripheral stroke among in Million Veteran Program. Methods: performed a time-to-event analysis retrospective...
The aim of this study was to explore the dose response licogliflozin, a dual inhibitor sodium/glucose cotransporter 1 (SGLT1) and 2 (SGLT2), by evaluating change in body weight adults with overweight or obesity.This dose-response analysis evaluated following 24 weeks four once-daily twice-daily licogliflozin doses (2.5-150 mg) versus placebo (primary end point). A further 24-week efficacy safety two maintaining initial reduction.Licogliflozin once daily twice produced significant signal for...
Context Rosmarinic acid (RosA), a natural poly-phenolic compound isolated from variety of Labiatae herbs, has been reported to have range biological effects.Objective To investigate the cardioprotective effects RosA against myocardial ischaemia/reperfusion (I/R) injury.Materials and methods Male C57BL/6J mice were given (100 mg/kg) via intragastric administration. After 1 week administration, subjected 30 min/24 h I/R injury. The randomly subdivided into 4 groups: Vehicle, RosA, Vehicle +...
The incidence of hepatocellular carcinoma (HCC) decreases significantly in chronic hepatitis C (CHC) patients with sustained virologic response (SVR) after pegylated-interferon plus ribavirin (PR) or direct-acting antiviral (DAAs) therapy. We follow-up a single cohort CHC to identify risk factors associated HCC development post-SVR.CHC SVR Beijing/Hong Kong were followed up at 12-24 weekly intervals surveillance for by ultrasonography and alpha-fetoprotein (AFP). Multivariate Cox...
Single-cell RNA sequencing (scRNA-seq) in plants requires the isolation of high-quality protoplasts - cells devoid cell walls. However, many plant tissues and organs are resistant to enzymatic digestion, posing a significant barrier advancing single-cell multi-omics research plants. Furthermore, for field-grown crops, lack immediate laboratory access presents another major challenge protoplast preparation. To address these limitations, we developed FX-Cell method its derivatives, FXcryo-Cell...
Introduction Breast cancer is the most common malignant tumor among women worldwide, and microenvironment (TME) has become a hot research field in contemporary oncology. Understanding TME essential for elucidating mechanisms of breast progression identifying novel therapeutic targets metastasis recurrence. This study performed bibliometric analysis cancer, providing comprehensive overview current hotspots, development trends, directions. Methods We retrieved literature on published during...
ABSTRACT Schisandrin B (Sch B), a natural lignan extracted from schisandra chinesis, has exhibited various pharmacological activities including anticancer effects. However, studies on the preclinical toxicokinetic profile of Sch have not been publicly reported. This study aimed to investigate concomitant toxicokinetics multiple administration B. was administered orally rats and dogs at 150, 300, 600 mg/kg/day 50, 100, 200 mg/kg/day, respectively, for 26 weeks. Plasma concentrations were...
Abstract Alternative splicing (AS) is a major mechanism for diversifying mRNA transcripts and regulating protein expression. Most tumors exhibit widespread abnormalities relative to peritumoral healthy tissues, including frequent retention of normally excised introns, inappropriate expression isoforms restricted other cell types or developmental stages, errors that disable tumor suppressors promote oncogene The CDC2-like kinases (CLKs) dual-specificity tyrosine-regulated (DYRKs) are thought...
Proteins are crucial in a wide range of biological and engineering processes. Large protein language models (PLMs) can significantly advance our understanding proteins. However, the effectiveness PLMs prediction design is largely based on representations derived from sequences. Without incorporating three-dimensional structures proteins, would overlook aspects how proteins interact with other molecules, thereby limiting their predictive accuracy. To address this issue, we present S-PLM, 3D...