A5079882589- Advanced Glycation End Products research
- Phytochemicals and Antioxidant Activities
- Tea Polyphenols and Effects
- Traditional Chinese Medicine Analysis
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginkgo biloba and Cashew Applications
- Neurological Disease Mechanisms and Treatments
- Meat and Animal Product Quality
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Potato Plant Research
- Parkinson's Disease Mechanisms and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Gut microbiota and health
- Sesame and Sesamin Research
- Cerebrospinal fluid and hydrocephalus
- Polyamine Metabolism and Applications
- Biochemical and biochemical processes
- Soil Mechanics and Vehicle Dynamics
- Dementia and Cognitive Impairment Research
- Metabolomics and Mass Spectrometry Studies
- Agricultural Engineering and Mechanization
Sichuan University
2020-2025
West China Hospital of Sichuan University
2022-2025
Hunan Agricultural University
2019-2025
State Key Laboratory of Food Science and Technology
2017-2024
Jiangnan University
2017-2024
Chinese Academy of Geological Sciences
2024
China University of Geosciences (Beijing)
2024
Tianjin Medical University General Hospital
2016-2024
AstraZeneca (United Kingdom)
2024
Air Force Medical University
2013-2023
As cardiovascular disease (CVD) morbidity and mortality increase yearly, this study aimed to explore the potential of weight-adjusted-waist index (WWI) its relation long-term in patients with CVD. The diagnosis CVD was based on standardized medical condition questionnaires that incorporated participants' self-reported physician diagnoses. WWI (cm/√kg) is a continuous variable calculated as waist circumference (WC, cm) divided by square root body weight (kg). For analysis purposes,...
Aging-associated cognitive dysfunction has a great influence on the lifespan and healthspan of elderly. Theaflavins (TFs), mixture ingredients formed from enzymatic oxidation catechins during manufacture tea, have positive contribution to qualities antiaging activities black tea. However, role TFs in mitigating aging-induced underlying mechanism remains largely unknown. Here, we find that effectively improve behavioral impairment via microbiota-gut-brain axis: maintain gut homeostasis by...
Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson’s disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to unknown. To answer this question, mice received MPTP intraperitoneally construct subacute model and were then supplemented with orally 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, neurogenesis...
Epigallocatechin gallate (EGCG), the key constituent of tea polyphenols, presents challenges in terms its lipid solubility, stability, and bioavailability because polyhydroxy structure. Consequently, structural modifications are imperative to enhance efficacy. This paper comprehensively reviews esterification techniques applied EGCG over past two decades their impacts on bioactivities. Both chemical enzymatic methods involve catalysts, solvents, hydrophobic groups as critical factors....
Abstract Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. meningeal lymphatic vessel (mLV) drainage pathway is a novel system that takes part in waste products central nervous (CNS). This study aimed to explore roles mLV SDH its impacting factors. We injected FITC-500D, A488-fibrinogen autologous blood into subdural space mice/rats found these...
To examine the knowledge level, behaviors, and psychological status of Chinese population during COVID-19 pandemic, to explore differences between urban rural areas.We carried out a cross-sectional survey knowledge, behaviors related COVID-19, mental health in probability sample 3001 community residents 30 provinces or districts across China from February 16-23, 2020. Convenience sampling snowball were adopted. We used General Anxiety Disorder (GAD), 9-item Patient Health Questionnaire...
Acrylamide is a toxic compound that produced widely during food processing, but whether the daily dietary consumption of acrylamide can impair cognitive dysfunction in diabetic individuals and potential underlying mechanisms are unknown. The aim present study was to observe changes memory performance caused by chronic exposure evaluate its influence on brain morphology, oxidative damage, neuroinflammation, metabolic disturbance. Goto-Kakizaki (GK) rats, rat model diabetes, were orally...
Summary The in vitro digestive stability of phenolic compounds and the antioxidant capacity five kinds commonly consumed fruit juices daily diet, including apple juice ( AJ ), orange OJ grape GJ pomelo PJ ) kiwifruit KJ were studied. Following digestion, total TP content decreased to different extents by 35%, 25.3%, 23.5%, 22.2% 7.8% for , respectively. individual showed similar changes content, showing reductions naringenin‐trisaccharide epicatechin chlorogenic acid 43.74%, 27.59%, 47.11%...
In the present study, citrus peels were extracted using various conventional and deep eutectic solvents (DESs). Compared to other peel extracts, DES extract based on choline chloride showed notably higher total phenolic flavonoid content levels, along with superior antioxidant activity, among these extracts. Consequently, this study aimed further investigate inhibitory effects of production both free bound heterocyclic amines (HAs) advanced glycation end products (AGEs) in roast pork meat...
Hyperglycemia can cause early damage to cells of vasculature and target organs develop into diabates that will severely threaten human healthy. The effectively clinical treatment hyperglycemiais is by inhibiting the activity α-amylase. Black tea has been reported show inhibitory effect on α-amylase be used for hyperglycemia treatment. However, mechanism underlying unclear. In this study, in vivo experiment showed black theaflavins extract (BTE) alleviated hyperglycemia. vitro effects may...
Abstract Background Diffuse brain injury (DBI) models are characterized by intense global inflammation and edema, which characterize the most severe form of TBI. In a previous experiment, we found that fingolimod promoted recovery after controlled cortical impact (CCI) modulating around lesions. However, it remains unclear whether can also attenuate DBI because its different mechanisms. Furthermore, has additional underlying effects on repairing is unknown. Methods The acceleration model was...
JOURNAL/nrgr/04.03/01300535-202508000-00026/figure1/v/2024-09-30T120553Z/r/image-tiff Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon 7-mediated signaling contributes to Parkinson’s disease remains unknown. Here we report that is markedly up-regulated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–induced mouse model of and co-localizes with microglial cells. Both selective cyclic guanosine monophosphate adenosine synthase...