A5100448594- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Burn Injury Management and Outcomes
- Pregnancy and preeclampsia studies
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetic Foot Ulcer Assessment and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Metabolism, Diabetes, and Cancer
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Pituitary Gland Disorders and Treatments
- Cardiac Health and Mental Health
- Meningioma and schwannoma management
- Chronic Disease Management Strategies
- Lipid metabolism and disorders
Heilongjiang Provincial Hospital
2017-2025
Shandong University of Traditional Chinese Medicine
2025
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2016-2024
Sichuan University
2011-2024
West China Hospital of Sichuan University
2022-2024
Yibin University
2024
Jianghan University
2023
Capital Medical University
2019-2023
Beijing Anzhen Hospital
2023
Many pesticides have been identified as endocrine-disrupting chemicals (EDCs) due to their ability bind sex-steroid hormone receptors. However, little attention has paid the of interfere with other steroid receptors such glucocorticoid receptor (GR) that plays a critical role in metabolic, endocrine, immune, and nervous systems. In this study, glucocorticoidic antiglucocorticoidic effects 34 on human GR were investigated using luciferase reporter gene assay. Surprisingly, none test showed...
Colorectal cancer is a severe health problem worldwide, and accumulating evidence supports the contribution of Fusobacterium nucleatum (F. nucleatum) to colorectal development, metastasis, chemoresistance. However, mechanisms underlying colonization F. in tissue are not yet clarified. Here we demonstrate that infection mediated elevation angiopoietin-like 4 (ANGPTL4) expression. Upregulated ANGPTL4 promoted glucose uptake glycolysis activity cells vitro vivo, which necessary for nucleatum....
Adenomyosis is a common estrogen-dependent disorder of females characterized by downward extension the endometrium into uterine myometrium and neovascularization in ectopic lesions. It accounts for chronic pelvic pain, dysmenorrhea, menorrhagia, infertility 8.8–61.5% women worldwide. However, molecular mechanisms adenomyosis development remain poorly elucidated. Here, we utilized two-dimensional polyacrylamide gel electrophoresis/MS-based proteomics analysis to compare identify...
Cancer cells frequently use fructose as an alternative energy and carbon source, to fuel glycolysis support the synthesis of various biomacromolecules.Glut5 is only fructose-specific transporter, which lacks ability transport other carbohydrates such glucose galactose.Interplay between inflammatory factors cancer renders tissue environment a predisposing condition for development.Nevertheless, how coordinate with metabolism facilitate tumor growth remains largely elusive.Here we show that...
Abstract Background The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but colorectal carcinoma (CRC) remains be established. purpose this study was investigate expression pattern significance CRC progression. Method 265 specimens 129 matched adjacent normal mucosa were collected. Expression clinical samples examined by immunostaining. effect on cell proliferation measured MTT assay,...
Abstract Background The number of older adults with physical multi-morbidity is increasing. As Internet-based eHealth and mHealth increasingly require patients to use technology, it important examine the Internet/health information technology (HIT) among multi-morbidity. Here we distribution multi-morbidity, Internet use, HIT further explored factors associated Methods One wave data from 2018 US National Health Interview Survey (NHIS) was analysed. We included respondents aged 65 years...
The objective of this study was to examine the associations reproductive factors and exogenous hormone use with risk Parkinson's disease (PD) among postmenopausal women. comprised 119,166 women aged 50 71 years in NIH-AARP Diet Health Study, who completed a baseline questionnaire 1995-1996 follow-up survey 2004-2006. A total 410 self-reported PD diagnoses were identified between 1995 2006. Multivariate odds ratios (ORs) 95% confidence intervals (CIs) derived from logistic regression models....
The offspring of gestational diabetes mellitus (GDM) mothers are considered to be at the risk cardiovascular diseases due intrauterine hyperglycemia exposure. Our previous study showed that zinc, selenium, and chromium dramatically alleviated glucose intolerance in GDM rats their (P < 0.05). However, effects these elements on damage cardiac myocytes underlying mechanisms have not been demonstrated. Here, we investigated beneficial zinc (10 mg per kg bw), selenium (20 μg bw) supplementation...
GLP-1 has a variety of anti-diabetic effects. However, native is not suitable for therapy diabetes due to its short half-life (t1/2<2 min). To circumvent this, we developed long-lasting receptor agonist by the fusion with human IgG2 Fc (GLP-1/hIgG2). ELISA-based binding assay demonstrated that GLP-1/hIgG2 had high affinity GLP-1R in INS-1 cells (Kd = 13.90±1.52 nM). Upon binding, was rapidly internalized dynamin-dependent manner. Insulin RIA showed GLP-1/IgG2 dose-dependently stimulated...
Background/Aims: Acute ST-segment elevation of myocardial infarction (STEMI) is the most severe type acute coronary syndrome (ACS). Particular attention has been focused on studying pathogenesis STEMI, and how to prevent thrombosis, reduce inflammatory reaction, stabilize plaques improve vascular endothelial functions preserve survived myocardium. This study aimed compare anti-inflammatory endothelium-protective effects, clinical prognosis, relevant bleeding risks ticagrelor versus...
Background Non-alcoholic fatty liver disease (NAFLD) caused by lipid dysregulation is linked to obesity. Somatostatin (SST) and its analogs have been used treat pediatric hypothalamic However, the application of such drugs for treatment NAFLD has not evaluated. Objective This study aimed investigate expression levels important regulators hepatic metabolism possible effect SST analog octreotide on these regulators. Methods SD rats were assigned a control group high-fat diet group. Obese from...
This study evaluated the haemodynamic significance of intracranial atherosclerotic stenosis using quantitative flow ratio analysis in 412 patients, developing a nomogram integrating it and risk factors to effectively discriminate symptomatic lesions.