A5068153858- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Aortic Thrombus and Embolism
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Mechanical Circulatory Support Devices
- Cardiovascular Disease and Adiposity
- Nuclear Structure and Function
- Cardiovascular and exercise physiology
- Cardiac pacing and defibrillation studies
- RNA Research and Splicing
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Signaling Pathways in Disease
- Parathyroid Disorders and Treatments
- Muscle Physiology and Disorders
- Electrolyte and hormonal disorders
- Cardiac electrophysiology and arrhythmias
Osaka City University
2014-2023
Osaka Metropolitan University
2022-2023
Osaka City University Hospital
2022
Tokyo Metropolitan University
2022
Columbia University
2011-2015
Columbia University Irving Medical Center
2011-2014
Royal College of Physicians
2014
New York Proton Center
2014
Northwestern University
2013
Stony Brook University
2012
Rationale: Efficient clearance of apoptotic cells (efferocytosis) is a prerequisite for inflammation resolution and tissue repair. After myocardial infarction, phagocytes are recruited to the heart promote dying cardiomyocytes. The molecular mechanisms efferocytosis cardiomyocytes in myocardium unknown. injured provides unique model examine relationships between subsequent resolution, remodeling, organ function. Objective: We set out identify cardiomyocyte engulfment by and, first time,...
Cardiomyopathy arising from lamin A/C mutations in mice can be corrected by enhancing autophagy through blockade of mTOR with temsirolimus.
Continuous-flow left ventricular assist devices (LVAD) are increasingly used for patients with end-stage heart failure (HF). We analyzed the effects of decompression by continuous-flow versus pulsatile-flow LVADs on myocardial structure and function in this population.Sixty-one who underwent LVAD implantation as bridge-to-transplant were (pulsatile-flow LVAD: group P, n=31; C, n=30). Serial echocardiograms, serum levels brain natriuretic peptide (BNP), extracellular matrix biomarkers (ECM)...
Spinal muscular atrophy is a common motor neuron disease caused by low survival motoneuron (SMN), key protein in the proper splicing of genes. Restoring therefore promising therapeutic strategy. Implementation this strategy, however, depends on defining temporal requirements for SMN. Here, we used controlled knockdown SMN transgenic mice to determine precise postnatal stage protein. Reducing neonatal resulted classic SMA-like phenotype. Unexpectedly, depletion adults had relatively little...
We previously interrogated the transcriptome in heart tissue from LmnaH222P/H222P mice, a mouse model of cardiomyopathy caused by lamin A/C gene (LMNA) mutation, and found that extracellular signal-regulated kinase 1/2 Jun N-terminal branches mitogen-activated protein (MAP) signaling pathway were abnormally hyperactivated prior to onset significant cardiac impairment. have now used an alternative expression analysis tool reanalyze this identify hyperactivation third branch MAP cascade, p38α...
AimsMutations in A-type nuclear lamins gene, LMNA, lead to a dilated cardiomyopathy. We have reported abnormal activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signalling hearts from LmnaH222P/H222P mice, which develop therefore determined whether an inhibitor ERK1/2 that has been investigated clinical trials for cancer potential be translated humans with LMNA
We recently demonstrated that mild primary hyperparathyroidism (PHPT) is associated with increased carotid intima-media thickness (IMT) and stiffness, aortic valve calcification. It unclear whether parathyroidectomy (PTX) improves these abnormalities. The purpose of this study was to determine cardiovascular abnormalities in PHPT improve PTX.Forty-four patients were studied using ultrasound transthoracic echocardiography before after PTX. Carotid IMT, plaque left ventricular mass index...
It is unclear whether cardiovascular disease present in primary hyperparathyroidism (PHPT). Aortic valve structure and function were compared PHPT patients population-based controls. This a case-control study. The study was conducted university hospital metabolic bone unit. We studied 51 with 49 measured the aortic calcification area transaortic pressure gradient. significantly higher (0.24 ± 0.02 vs. 0.17 cm2, p<0.01), although there no difference peak gradient, functional measure of...
Mutations in the lamin A/C gene (LMNA) encoding A-type nuclear lamins cause dilated cardiomyopathy with variable muscular dystrophy. These mutations enhance mitogen-activated protein kinase signaling heart and pharmacological inhibition of extracellular signal-regulated (ERK) 1 2 improves cardiac function LmnaH222P/H222P mice. In current study, we crossed mice lacking ERK1 to examined performance survival. Male LmnaH222P/H222P/Erk1−/− had smaller left ventricular end systolic diameters...
Background In this study, we sought to investigate the 2‐year prognostic impact of B‐type natriuretic peptide ( BNP ) levels at discharge, following transcatheter aortic valve replacement. Methods and Results We enrolled 1094 consecutive patients who underwent replacement between 2013 2016. Study were stratified into 2 groups according survival classification regression tree analysis (high versus low groups). evaluated high on mortality compared with that using a multivariable Cox model,...
Aortic valve calcification (AVC) without outflow obstruction (stenosis) is common in the elderly and increases risk of cardiovascular morbidity mortality. Although high blood pressure (BP) measured at doctor’s office known to be associated with AVC, little about association between 24-hour ambulatory BP (ABP) AVC. Our objective was clarify ABP variables The study population consisted 737 patients (mean age, 71±9 years) participating Cardiovascular Abnormalities Brain Lesions who underwent...
Abstract Aims We aimed to develop models detect aortic stenosis (AS) from chest radiographs—one of the most basic imaging tests—with artificial intelligence. Methods and results used 10 433 retrospectively collected digital radiographs 5638 patients train, validate, test three deep learning models. Chest were who had also undergone echocardiography at a single institution between July 2016 May 2019. These labelled corresponding assessments as AS-positive or AS-negative. The separated on...
After influenza vaccination an 83-year-old woman was referred to us because of fever and sore throat with no response antibiotics. Chest computed tomography showed thickened bronchovascular bundles, multiple nodules feeding vessels, consolidation. Laboratory tests a high level serum myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) soluble interleukin-2 receptor (sIL-2R), as well abnormal renal function urinary sediment. Transbronchial lung biopsy revealed organizing pneumonia....
The planimetry method using three-dimensional (3D) echocardiography is useful for providing an accurate mitral annulus area (MAA) value. However, this relatively unavailable. Therefore, we evaluated the accuracy of conventional methods MAA measurement compared with that 3D planimetry. Two-dimensional (2D) and transoesophageal (TEE) were performed in 70 patients. diameter (MAD) was measured four standard TEE imaging planes: four-chamber (4Ch), two-chamber (2Ch), anterior–posterior (LAX),...
To develop an artificial intelligence-based model to detect mitral regurgitation on chest radiographs.This retrospective study included echocardiographs and associated radiographs consecutively collected at a single institution between July 2016 May 2019. Associated were those obtained within 30 days of echocardiography. These labeled as positive or negative for the basis echocardiographic reports divided into training, validation, test datasets. An intelligence was developed by using...